Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Majken S Siersbæk"'
Autor:
Stine M Præstholm, Majken S Siersbæk, Ronni Nielsen, Xuguang Zhu, Anthony N Hollenberg, Sheue-Yann Cheng, Lars Grøntved
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008770 (2020)
Hormone-dependent activation of enhancers includes histone hyperacetylation and mediator recruitment. Histone hyperacetylation is mostly explained by a bimodal switch model, where histone deacetylases (HDACs) disassociate from chromatin, and histone
Externí odkaz:
https://doaj.org/article/cb6ed51b97f14868bda779eb26f0dd66
Autor:
Adrija Kalvisa, Majken S Siersbæk, Stine M Præstholm, Line J L Christensen, Ronni Nielsen, Oliver Stohr, Sabine Vettorazzi, Jan Tuckermann, Morris White, Susanne Mandrup, Lars Grøntved
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e2006249 (2018)
Hepatic circadian gene transcription is tightly coupled to feeding behavior, which has a profound impact on metabolic disorders associated with diet-induced obesity. Here, we describe a genomics approach to uncover mechanisms controlling hepatic post
Externí odkaz:
https://doaj.org/article/841ba87aa5ad4ec1bfb471d49df38f9f
Autor:
Frederik T. Larsen, Daniel Hansen, Mike K. Terkelsen, Sofie M. Bendixen, Fabio Avolio, Charlotte W. Wernberg, Mette M. Lauridsen, Lea L. Grønkjaer, Birgitte G. Jacobsen, Ellen G. Klinggaard, Susanne Mandrup, Tina Di Caterino, Majken S. Siersbæk, Vineesh Indira Chandran, Jonas H. Graversen, Aleksander Krag, Lars Grøntved, Kim Ravnskjaer
Publikováno v:
JHEP Reports, Vol 5, Iss 2, Pp 100615- (2023)
Background & Aims: Histological assessment of liver biopsies is the gold standard for diagnosis of non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD), despite its well-established limitations. Ther
Externí odkaz:
https://doaj.org/article/018dbabd75474726b81d204c600b8e22
Autor:
Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness. The altered ECM of the
Externí odkaz:
https://doaj.org/article/a8b31eed6af14bd29e66f25eb8528c73
Autor:
Jens Kjeldsen, Michael Schmidt, Yan Yan, Hans Erik Bøtker, Gunvor Iben Madsen, Thomas Ravn Lassen, Aleksander Krag, Michael M. Nielsen, Sara K. Tjønnfjord, Jørgen Kjems, Nichlas Riise Jespersen, Majken S. Siersbæk, Lars Grøntved, Line E. Godskesen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Godskesen, L E, Lassen, T R, Jespersen, N R, Siersbæk, M, Yan, Y, Nielsen, M M, Tjønnfjord, S K, Grøntved, L, Madsen, G, Kjems, J, Bøtker, H E, Schmidt, M R, Krag, A & Kjeldsen, J 2020, ' Remote ischemic conditioning in active ulcerative colitis : An explorative randomized clinical trial ', Scientific Reports, vol. 10, 9537 . https://doi.org/10.1038/s41598-020-65692-9
Godskesen, L E, Lassen, T R, Jespersen, N R, Siersbæk, M, Yan, Y, Nielsen, M M, Tjønnfjord, S K, Grøntved, L, Madsen, G, Kjems, J, Bøtker, H E, Schmidt, M R, Krag, A & Kjeldsen, J 2020, ' Remote ischemic conditioning in active ulcerative colitis : An explorative randomized clinical trial ', Scientific Reports, vol. 10, no. 1, 9537 . https://doi.org/10.1038/s41598-020-65692-9
Scientific Reports
Godskesen, L E, Lassen, T R, Jespersen, N R, Siersbæk, M, Yan, Y, Nielsen, M M, Tjønnfjord, S K, Grøntved, L, Madsen, G, Kjems, J, Bøtker, H E, Schmidt, M R, Krag, A & Kjeldsen, J 2020, ' Remote ischemic conditioning in active ulcerative colitis : An explorative randomized clinical trial ', Scientific Reports, vol. 10, 9537 . https://doi.org/10.1038/s41598-020-65692-9
Godskesen, L E, Lassen, T R, Jespersen, N R, Siersbæk, M, Yan, Y, Nielsen, M M, Tjønnfjord, S K, Grøntved, L, Madsen, G, Kjems, J, Bøtker, H E, Schmidt, M R, Krag, A & Kjeldsen, J 2020, ' Remote ischemic conditioning in active ulcerative colitis : An explorative randomized clinical trial ', Scientific Reports, vol. 10, no. 1, 9537 . https://doi.org/10.1038/s41598-020-65692-9
Remote ischemic conditioning (RIC) by repetitive brief periods of limb ischemia and reperfusion renders organs more resistant to ischemic injury. The protection is partly through down-regulation of the inflammatory response. Our aim was to investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d8ec0286dface8e1c2e5156714ab3f
http://link.springer.com/article/10.1038/s41598-020-65692-9
http://link.springer.com/article/10.1038/s41598-020-65692-9
Autor:
Catarina M. Correia, Stine M. Præstholm, Felix B. Pedersen, Jesper F. Havelund, Majken S. Siersbæk, Morten F. Ebbesen, Jonathan Brewer, Steen Larsen, Zach Gerhart-Hines, Blagoy Blagoev, Nils J. Færgeman, Lars Grøntved
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df817c5f92b7e7b6dec24536a1a405c
https://doi.org/10.2139/ssrn.4111607
https://doi.org/10.2139/ssrn.4111607
Autor:
Majken S. Siersbæk, Mathilde Jørgensen, Victor E Goitea, Stine M. Præstholm, Jesper F. Havelund, Nils J. Færgeman, Catarina M. Correia, Thomas Åskov Pedersen, Lars Grøntved
Publikováno v:
Præstholm, S M, Correia, C M, Goitea, V E, Siersbæk, M S, Jørgensen, M, Havelund, J F, Pedersen, T Å, Færgeman, N J & Grøntved, L 2021, ' Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage ', Cell Reports, vol. 37, no. 5, 109938 . https://doi.org/10.1016/j.celrep.2021.109938
Cell Reports, Vol 37, Iss 5, Pp 109938-(2021)
Cell Reports, Vol 37, Iss 5, Pp 109938-(2021)
Summary: The transition from a fasted to a fed state is associated with extensive transcriptional remodeling in hepatocytes facilitated by hormonal- and nutritional-regulated transcription factors. Here, we use a liver-specific glucocorticoid recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99b6c8dafa970de48a48565ff0fe411
https://doi.org/10.1016/j.celrep.2021.109938
https://doi.org/10.1016/j.celrep.2021.109938
Autor:
Niels Behrendt, Daniel H. Madsen, Majken S. Siersbæk, Loretta Grey Cloud, Lars Grøntved, Henrik J. Jürgensen, Shihui Liu, Dorota Ewa Kuczek, Thomas H. Bugge, Roberto Weigert
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3662-3671 (2017)
Madsen, D H, Jürgensen, H J, Siersbæk, M S, Kuczek, D E, Grey Cloud, L, Liu, S, Behrendt, N, Grøntved, L, Weigert, R & Bugge, T H 2017, ' Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake ', Cell Reports, vol. 21, no. 13, pp. 3662-3671 . https://doi.org/10.1016/j.celrep.2017.12.011
Madsen, D H, Jürgensen, H J, Siersbæk, M S, Kuczek, D E, Grey Cloud, L, Liu, S, Behrendt, N, Grøntved, L, Weigert, R & Bugge, T H 2017, ' Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake ', Cell Reports, vol. 21, no. 13, pp. 3662-3671 . https://doi.org/10.1016/j.celrep.2017.12.011
Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins. Here, we use int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147f676c46991d8d4d51dc74e94b1a2
http://www.sciencedirect.com/science/article/pii/S2211124717318077
http://www.sciencedirect.com/science/article/pii/S2211124717318077
Autor:
Majken S. Siersbæk, Sheue-yann Cheng, Anthony N. Hollenberg, Lars Grøntved, Ronni Nielsen, Xuguang Zhu, Stine M. Præstholm
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 5, p e1008770 (2020)
Præstholm, S M, Siersbæk, M S, Nielsen, R, Zhu, X, Hollenberg, A N, Cheng, S-Y & Grøntved, L 2020, ' Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone ', PLOS Genetics, vol. 16, no. 5, e1008770 . https://doi.org/10.1371/journal.pgen.1008770
PLoS Genetics, Vol 16, Iss 5, p e1008770 (2020)
Præstholm, S M, Siersbæk, M S, Nielsen, R, Zhu, X, Hollenberg, A N, Cheng, S-Y & Grøntved, L 2020, ' Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone ', PLOS Genetics, vol. 16, no. 5, e1008770 . https://doi.org/10.1371/journal.pgen.1008770
Hormone-dependent activation of enhancers includes histone hyperacetylation and mediator recruitment. Histone hyperacetylation is mostly explained by a bimodal switch model, where histone deacetylases (HDACs) disassociate from chromatin, and histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd81d267b38f828236f1d7df9844b675
https://pubmed.ncbi.nlm.nih.gov/32453730
https://pubmed.ncbi.nlm.nih.gov/32453730
Autor:
Marco Carretta, Dorota Ewa Kuczek, Majken S. Siersbæk, Daniel H. Madsen, Adrija Kalvisa, Ole Vang, Anne Mette Hvid Larsen, Marie-Louise Thorseth, Astrid Z. Johansen, Lars Grøntved
Publikováno v:
Larsen, A M H, Kuczek, D E, Kalvisa, A, Siersbæk, M S, Thorseth, M L, Johansen, A Z, Carretta, M, Grøntved, L, Vang, O & Madsen, D H 2020, ' Collagen Density Modulates the Immunosuppressive Functions of Macrophages ', Journal of immunology (Baltimore, Md. : 1950), vol. 205, no. 5, pp. 1461-1472 . https://doi.org/10.4049/jimmunol.1900789
Tumor-associated macrophages (TAMs) support tumor growth by suppressing the activity of tumor-infiltrating T cells. Consistently, TAMs are considered a major limitation for the efficacy of cancer immunotherapy. However, the molecular reason behind th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73deed7cf30f10217028d000019bb3bf
https://pubmed.ncbi.nlm.nih.gov/32839214
https://pubmed.ncbi.nlm.nih.gov/32839214