Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Majken Dalgaard"'
Autor:
Johannes Josef Fels, Henrik Søeborg, Inger Thorup, Mikala Skydsgaard, Lærke W. Andersen, Hanne Offenberg, Kevin A. Keane, Charlotte M. Dalsgaard, Ingrid Sjögren, Jennifer M. Rojas, Line Olrik Berthelsen, Jette Nowak, Florian Bolze, Jes Tovborg Jensen, Majken Dalgaard
Publikováno v:
Toxicologic Pathology. 46:777-798
The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720b22f18b55257c12209b4651c6fd5d
https://doi.org/10.1177/0192623318803557
https://doi.org/10.1177/0192623318803557
Publikováno v:
Bone. 145:115781
The implications of obesity and weight loss for human bone health are not well understood. Although the bone changes associated with weight loss are similar in humans and rodents, that is not the case for obesity. In humans, obesity is generally asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d51745db5acc836bb4522ec0ecc1ad
https://doi.org/10.1016/j.bone.2020.115781
https://doi.org/10.1016/j.bone.2020.115781
Autor:
Emil Egecioglu, Majken Dalgaard, Marie Østergaard Pedersen, Birgitte Schjellerup Wulff, Mikala Skydsgaard, Alan Broadmeadow, Clare J. Chesher, Ridhirama Bhuwania, Esther Bloem, Emma Moore, Manuel Tena-Sempere, Hannah Williams, Lærke W. Andersen, Pia Søndergaard Galle, Florian Bolze, Johan F. Paulsson
Publikováno v:
Toxicology and Applied Pharmacology. 404:115152
Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c0139312e6bed6d38c6b05112dbcd
https://doi.org/10.1016/j.taap.2020.115152
https://doi.org/10.1016/j.taap.2020.115152
Autor:
Christine Nellemann, Julie Boberg, Marta Axelstad, Leon J. S. Brokken, Stine Broeng Metzdorff, Majken Dalgaard, Anne Marie Vinggaard, Rasmus Wortziger
Publikováno v:
Toxicology. 250:75-81
Endocrine disrupting chemicals can induce malformations and impairment of reproductive function in experimental animals and may have similar effects in humans. Recently, the environmental obesogen hypothesis was proposed, suggesting that environmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc2f1e9d5b9894bac5260bb3dd523ce
https://doi.org/10.1016/j.tox.2008.05.020
https://doi.org/10.1016/j.tox.2008.05.020
Publikováno v:
Pharmacology & Toxicology. 86:92-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b24532254747b52da37f9dfbd0911ed
https://doi.org/10.1034/j.1600-0773.2000.pto860208.x
https://doi.org/10.1034/j.1600-0773.2000.pto860208.x
Autor:
Anne Marie Vinggaard, Julie Boberg, Majken Dalgaard, Ulla Hass, Helle Raun Andeasen, Camilla Taxvig, Marta Axelstad
Publikováno v:
Taxvig, C, Hass, U, Axelstad, M, Dalgaard, M, Boberg, J, Andersen, H R & Vinggard, A M 2007, ' Endocrine disrupting activities in vivo of the fungicides tebuconazole and epoxiconazole ', Toxicological Sciences, vol. 100, no. 2, pp. 464-473 . https://doi.org/10.1093/toxsci/kfm227
Udgivelsesdato: Sep 4 The triazole fungicides tebuconazole and epoxiconazole were investigated for reproductive toxic effects after exposure during gestation and lactation. Rats were dosed with epoxiconazole (15 or 50 mg/kg bw/day) or tebuconazole (5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba1620d61ec555927b9c88f80276bf7
https://doi.org/10.1093/toxsci/kfm227
https://doi.org/10.1093/toxsci/kfm227
Autor:
Julie Borch, Leon J. S. Brokken, Stine Broeng Metzdorff, Majken Dalgaard, Anne Marie Vinggaard
Publikováno v:
Toxicology. 223:144-155
Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in consumer products and is known to disturb the development of the male reproductive system in rats. The mechanisms by which DEHP exerts these effects are not yet fully elucidated, though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a1e15024bcb716925931a354fbf9cf
https://doi.org/10.1016/j.tox.2006.03.015
https://doi.org/10.1016/j.tox.2006.03.015
Autor:
Ulla Hass, Eva Cecilie Bonefeld-Jørgensen, Sofie Christiansen, Helle Raun Andersen, Majken Dalgaard, Mette Erecius Poulsen, Anne Marie Vinggaard, Peter Laier
Publikováno v:
Vinggaard, A M, Hass, U, Dalgaard, M, Andersen, H R, Bonefeld-Jørgensen, E C, Christiansen, S, Laier, P & Poulsen, ME 2006, ' Prochloraz: an imidazole fungicide with multiple mechanisms of action ', International Journal of Andrology, vol. 29, no. 1, pp. 186-192 . https://doi.org/10.1111/j.1365-2605.2005.00604.x
Vinggaard, A M, Hass, U, Dalgaard, M, Andersen, H R, Bonefeld-Jørgensen, E, Christiansen, S, Laier, P & Poulsen, M E 2006, ' Prochloraz: an imidazole fungicide with multiple mechanishms of action ', International Journal of Andrology, vol. 29, pp. 186-192 . https://doi.org/10.1111/j.1365-2605.2005.00604.x
Vinggaard, A M, Hass, U, Dalgaard, M, Andersen, H R, Bonefeld-Jørgensen, E, Christiansen, S, Laier, P & Poulsen, M E 2006, ' Prochloraz: an imidazole fungicide with multiple mechanishms of action ', International Journal of Andrology, vol. 29, pp. 186-192 . https://doi.org/10.1111/j.1365-2605.2005.00604.x
Prochloraz is an imidazole fungicide that is widely used in Europe, Australia, Asia and South America within gardening and agriculture. Screening studies have shown that prochloraz elicits multiple mechanisms of action in vitro, as it antagonizes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c70c466526ea59e893c31dd3fe26fb
https://doi.org/10.1111/j.1365-2605.2005.00604.x
https://doi.org/10.1111/j.1365-2605.2005.00604.x
Autor:
Anne Marie Vinggaard, Christine Nellemann, Eva Cecilie Bonefeld-Jørgensen, Bjørn Holst, Majken Dalgaard
Publikováno v:
Nellemann, C, Dalgaard, M, Holst, B, Bonefeld-Jørgensen, E & Vinggaard, A M 2005, ' Gene expression changes in rat prostate after activation or blocking of the androgen and estrogen receptor ', Molecular and Cellular Endocrinology, vol. 237, no. 1-2, pp. 25-35 . https://doi.org/10.1016/j.mce.2005.04.002
Several endpoints of different molecular complexity were studied in the Hershberger assay in order to evaluate the specificity and suitability of this test as a broad screening model. Androgen and estrogen receptors were activated or blocked, and exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f46124e711790ce9d9cb17e9d7ec3b7
https://doi.org/10.1016/j.mce.2005.04.002
https://doi.org/10.1016/j.mce.2005.04.002
Autor:
Mette Erecius Poulsen, Majken Dalgaard, Christine Nellemann, Peter Laier, Helene Jacobsen, Anne Marie Vinggaard, Ulla Hass, Sofie Christiansen, Kirsten Jarfelt, V. Breinholt
Publikováno v:
Toxicological Sciences. 85:886-897
Prochloraz is a commonly used fungicide that has shown multiple mechanisms of action in vitro. It antagonizes the androgen and the estrogen receptors, agonizes the Ah receptor, and inhibits aromatase activity. In vivo prochloraz acts antiandrogenical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ec4054968437372ef3dadafb8f8698
https://doi.org/10.1093/toxsci/kfi150
https://doi.org/10.1093/toxsci/kfi150