Výsledky vyhledávání - "Majida Abu Shehab"

Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC

Autor: Thomas Jansson, Kyle K. Biggar, Shawn S.-C. Li, Madhulika B. Gupta, Niyati Malkani, Majida Abu Shehab

Publikováno v: Paediatrics Publications

Insulin-like growth factor binding protein-1 (IGFBP-1), secreted by fetal liver, is a key regulator of IGF-I bioavailability and fetal growth. IGFBP-1 phosphorylation decreases IGF-I bioavailability and diminishes its growth-promoting effects. Growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50af65cddecc2963c9c78453fad3ae0
https://doi.org/10.1016/j.mce.2015.12.006

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Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay

Autor: Karen Nygard, Kyle K. Biggar, Manthan R. Dhruv, Shawn S.-C. Li, Sahil S Singal, Thomas Jansson, Majida Abu Shehab, Madhulika B. Gupta

Publikováno v: Paediatrics Publications

Insulin-like growth factor binding protein (IGFBP)–1 influences fetal growth by modifying insulin-like growth factor–I (IGF-I) bioavailability. IGFBP-1 phosphorylation, which markedly increases its affinity for IGF-I, is regulated by mechanistic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac134bfd44d3cf2b41c2c29bf03fad17
https://ir.lib.uwo.ca/paedpub/269

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Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

Autor: Majida Abu Shehab, Madhulika B. Gupta, Theresa L. Powell, Thomas Jansson, Yi-Yung Chen, Fredrick J. Rosario

Publikováno v: Clinical Science (London, England : 1979)

Inhibition of placental mechanistic target of rapamycin (mTOR) signalling, which activates NEDD4-2 (neural precursor cell expressed developmentally down-regulated protein 4-2) ubiquitin ligase leading to increased sodium-coupled neutral amino acid tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff9809104f910229f434ae37fba6e5b
https://doi.org/10.1042/cs20150511

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Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity

Autor: Shawn S.-C. Li, Thomas Jansson, Sahil S Singal, Madhulika B. Gupta, Majida Abu Shehab, Kyle K. Biggar, Karen Nygard

Publikováno v: Paediatrics Publications

Phosphorylation of decidual IGFBP-1 enhances binding of IGF-I, limiting the bioavailability of this growth factor which may contribute to reduced placental and fetal growth. The mechanisms regulating decidual IGFBP-1 phosphorylation are incompletely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0071a4d375045f06d57821f5b5df3b95
https://ir.lib.uwo.ca/paedpub/1919

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Liver mTOR Controls IGF-I Bioavailability by Regulation of Protein Kinase CK2 and IGFBP-1 Phosphorylation in Fetal Growth Restriction

Autor: Thomas Jansson, Ian Damerill, Madhulika B. Gupta, Fredrick J. Rosario, Tong Shen, Amrita Kamat, Peter W. Nathanielsz, Mark J. Nijland, Majida Abu Shehab

Publikováno v: Paediatrics Publications

Fetal growth restriction (FGR) increases the risk for perinatal complications and predisposes the infant to diabetes and cardiovascular disease later in life. No treatment for FGR is available, and the underlying pathophysiology remains poorly unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797e1d9a9cbe2594cff073ea1a0f6805
https://doi.org/10.1210/en.2013-1759

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Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition

Autor: Thomas Jansson, Madhulika B. Gupta, Majida Abu Shehab, Kyle K. Biggar, Shawn S.-C. Li, Ian Damerill

Publikováno v: Paediatrics Publications

In fetal growth restriction (FGR), fetal growth is limited by reduced nutrient and oxygen supply. Insulin-like growth factor I (IGF-I) is a key regulator of fetal growth and IGF binding protein -1(IGFBP-1) is the principal regulator of fetal IGF-I bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb5f5ea794f5b8ffd624a478f707da9
https://ir.lib.uwo.ca/context/paedpub/article/3032/type/native/viewcontent/mend0201.pdf

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Phosphorylation of IGFBP-1 at discrete sites elicits variable effects on IGF-I receptor autophosphorylation

Autor: Cristiana Iosef, Madhulika B. Gupta, Girish Sardana, Robert Wildgruber, Majida Abu Shehab

Publikováno v: Paediatrics Publications

We previously demonstrated that hypoxia and leucine deprivation cause hyperphosphorylation of IGF-binding protein-1 (IGFBP-1) at discrete sites that markedly enhanced IGF-I affinity and inhibited IGF-I-stimulated cell growth. In this study we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f4159a3fc793da1cae2c6e8679e0f7
https://ir.lib.uwo.ca/paedpub/2330

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Site-Specific IGFBP-1 Hyper-Phosphorylation in Fetal Growth Restriction: Clinical and Functional Relevance

Autor: Brian H. Shilton, Madhulika B. Gupta, Majida Abu Shehab, Victor K. M. Han, Javad Khosravi

Publikováno v: Paediatrics Publications

Phosphorylation enhances IGFBP-1 binding to IGF-I, thereby limiting the bioavailability of IGF-I that may be important in fetal growth. Our goal in this study was to determine whether changes in site-specific IGFBP-1 phosphorylation were unique to fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98947feabcd4fe694509552a3916a29f
https://ir.lib.uwo.ca/paedpub/20

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