Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Majida, El Bakkouri"'
Autor:
Cyrielle Martini, Victoria Araba, Meriem Beniani, Paula Armoa Ortiz, Mimi Simmons, Mariem Chalbi, Abdelkader Mellouk, Majida El Bakkouri, Charles Calmettes
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Helicobacter pylori is a bacterium that exhibits strict host restriction to humans and non-human primates, and the bacterium is widely acknowledged as a significant etiological factor in the development of chronic gastritis, peptic ulcers, a
Externí odkaz:
https://doaj.org/article/39537aff6626420ba731ee1d5ceb832a
Autor:
Matthew Stuible, Joseph D. Schrag, Joey Sheff, Daria Zoubchenok, Simon Lord-Dufour, Brian Cass, Denis L’Abbé, Alex Pelletier, Martin A. Rossotti, Jamshid Tanha, Christian Gervais, Roger Maurice, Majida El Bakkouri, Mauro Acchione, Yves Durocher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimi
Externí odkaz:
https://doaj.org/article/dc399963cdec43a6ac763c16fa63044f
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Simon Joubert, Matthew Stuible, Simon Lord‐Dufour, Linda Lamoureux, François Vaillancourt, Sylvie Perret, Manon Ouimet, Alex Pelletier, Louis Bisson, Rohan Mahimkar, Phuong Lan Pham, Helene L′Ecuyer‐Coelho, Marjolaine Roy, Robert Voyer, Jason Baardsnes, Janelle Sauvageau, Frank St‐Michael, Anna Robotham, John Kelly, Andrea Acel, Joseph D. Schrag, Majida El Bakkouri, Yves Durocher
Protein expression from stably transfected Chinese hamster ovary (CHO) clones is an established but time-consuming method for manufacturing therapeutic recombinant proteins. The use of faster, alternative approaches, such as non-clonal stable pools,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da55dfe24cf776fdd3615002431c3ff
https://doi.org/10.1002/bit.28387
https://doi.org/10.1002/bit.28387
Autor:
David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth
Externí odkaz:
https://doaj.org/article/0c48607312374096801bf91f077ff9c0
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Gregory J Crowther, Heidi K Hillesland, Katelyn R Keyloun, Molly C Reid, Maria Jose Lafuente-Monasterio, Sonja Ghidelli-Disse, Stephen E Leonard, Panqing He, Jackson C Jones, Mallory M Krahn, Jack S Mo, Kartheek S Dasari, Anna M W Fox, Markus Boesche, Majida El Bakkouri, Kasey L Rivas, Didier Leroy, Raymond Hui, Gerard Drewes, Dustin J Maly, Wesley C Van Voorhis, Kayode K Ojo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite-
Externí odkaz:
https://doaj.org/article/5e2950d857f248d1802b59df2efcbcbc
Autor:
Hélène Malet, Kaiyin Liu, Majida El Bakkouri, Sze Wah Samuel Chan, Gregory Effantin, Maria Bacia, Walid A Houry, Irina Gutsche
Publikováno v:
eLife, Vol 3 (2014)
Externí odkaz:
https://doaj.org/article/37c8491903b947c6abd099bf4f2f7f66
Autor:
Hélène Malet, Kaiyin Liu, Majida El Bakkouri, Sze Wah Samuel Chan, Gregory Effantin, Maria Bacia, Walid A Houry, Irina Gutsche
Publikováno v:
eLife, Vol 3 (2014)
A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries–the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI–is reconstructed by cryo-electron microscopy to 11 Å
Externí odkaz:
https://doaj.org/article/9343808ba55947f2ad5ad1dc54e0f356
Autor:
Amarendar Reddy Maddirala, Jennifer Barks, Kevan M. Shokat, Nathaniel G. Jones, James W. Janetka, Majida El Bakkouri, Shaojun Long, Michael S. Lopez, Raymond Hui, L. David Sibley, Mary Savari Dhason, Qiuling Wang, Joshua B. Radke, Florentine U. Rutaganira
Publikováno v:
Journal of Medicinal Chemistry. 60:9976-9989
Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the opportunistic pathogen Toxoplasma gondii. CDPK1 controls multiple processes that are critical to the intracellular replicative cycle of T. gondii including secretion of adhesins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c7211cbe0739c75dffccbf8ac96328
https://doi.org/10.1021/acs.jmedchem.7b01192
https://doi.org/10.1021/acs.jmedchem.7b01192