Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Majid Laassri"'
Autor:
Hasmik Manukyan, Manjari Lal, Changcheng Zhu, Olga Singh, Tsai-Lien Lin, Erman Tritama, Konstantin Chumakov, Shwu-Maan Lee, Majid Laassri
Publikováno v:
Viruses, Vol 16, Iss 6, p 961 (2024)
Recently, a multiplex PCR-based titration (MPBT) assay was developed for simultaneous determination of infectious titers of all three Sabin strains of the oral poliovirus vaccine (OPV) to replace the conventional CCID50 assay, which is both time-cons
Externí odkaz:
https://doaj.org/article/cc78b81cce4b49279bea1b6ff8f398f7
Autor:
Hasmik Manukyan, Erman Tritama, Rahnuma Wahid, Jennifer Anstadt, John Konz, Konstantin Chumakov, Majid Laassri
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1729 (2023)
Recently, genetically stable novel OPVs (nOPV) were developed by modifying the genomes of Sabin viruses of conventional OPVs to reduce the risk of reversion to neurovirulence and therefore the risk of generating circulating vaccine-derived poliovirus
Externí odkaz:
https://doaj.org/article/34f3aa34084145a1b3672c421f3761bb
Autor:
Rahnuma Wahid, Laina Mercer, Andrew Macadam, Sarah Carlyle, Laura Stephens, Javier Martin, Konstantin Chumakov, Majid Laassri, Svetlana Petrovskaya, Saskia L. Smits, Koert J. Stittelaar, Chris Gast, William C. Weldon, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Pierre Van Damme, Ilse De Coster, Ricardo Rüttimann, Ananda Bandyopadhyay, John Konz
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease in recipients and susceptible contacts or evolve to become circulating vaccine-derived strains with the potential to cause outbreaks. Two novel type 2 OPV (nOPV2) c
Externí odkaz:
https://doaj.org/article/9baa83fb25b24bc98ad916e2a20f707d
Autor:
Lester M. Shulman, Majid Laassri, Rachel Handsher, Tatiana Zagorodnyaya, Danit Sofer, Merav Weil, Ella Mendelson, Konstantin Chumakov
Publikováno v:
Vaccines, Vol 10, Iss 12, p 2154 (2022)
Background: Poliovirus post-eradication containment of wild-type 2 poliovirus (PV2) requires the destruction of all materials containing, or potentially containing, PV2. Acute flaccid paralysis (AFP) cases in Israel between 1973 and 1988 were caused
Externí odkaz:
https://doaj.org/article/a520f694dd6c4969a023197911066a2e
Autor:
John O. Konz, Tim Schofield, Sarah Carlyle, Rahnuma Wahid, Azeem Ansari, Jeroen R.P.M. Strating, Ming Te Yeh, Hasmik Manukyan, Saskia L. Smits, Erman Tritama, Latri Rahmah, Dori Ugiyadi, Raul Andino, Majid Laassri, Konstantin Chumakov, Andrew Macadam
Publikováno v:
Vaccine: X, Vol 8, Iss , Pp 100102- (2021)
A novel, genetically-stabilized type 2 oral polio vaccine (nOPV2), developed to assist in the global polio eradication program, was recently the first-ever vaccine granted Emergency Use Listing by the WHO. Lot release tests for this vaccine included
Externí odkaz:
https://doaj.org/article/7805eacc4a144c3289cf7f764ff52931
Autor:
Hasmik Manukyan, Elvira Rodionova, Tatiana Zagorodnyaya, Tsai-Lien Lin, Konstantin Chumakov, Majid Laassri
Publikováno v:
Virology Journal, Vol 16, Iss 1, Pp 1-8 (2019)
Abstract Background Conventional assays to titrate polioviruses usually test serial dilutions inoculated into replicate cell cultures to determine a 50% cytopathic endpoint, a process that is both time-consuming and laborious. Such a method is still
Externí odkaz:
https://doaj.org/article/c64b8596977049468b73e8808c0dfd3d
Autor:
Hasmik Manukyan, Rahnuma Wahid, Azeem Ansari, Erman Tritama, Andrew Macadam, John Konz, Konstantin Chumakov, Majid Laassri
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1394 (2022)
Emergence of mutations is an inherent property of RNA viruses with several implications for their replication, pathogenesis, and evolutionary adaptation. Oral poliovirus vaccine (OPV), developed by Albert Sabin, is composed of live attenuated poliovi
Externí odkaz:
https://doaj.org/article/0012bbec5ca942d0aea2ed8185ef5ee1
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239015 (2020)
Understanding the extent and limitation of viral genome evolution can provide insight about potential drug and vaccine targets. Influenza B Viruses (IBVs) infect humans in a seasonal manner and causes significant morbidity and mortality. IBVs are neg
Externí odkaz:
https://doaj.org/article/5b3753e2285248ada5bd34e7ee397b29
Autor:
Hasmik Manukyan, Erman Tritama, Rahnuma Wahid, Azeem Ansari, John Konz, Konstantin Chumakov, Majid Laassri
Publikováno v:
Vaccines, Vol 9, Iss 7, p 688 (2021)
To control circulating vaccine-derived type 2 poliovirus outbreaks, a more genetically stable novel Oral Poliovirus Vaccine type 2 (nOPV2) was developed by targeted modifications of Sabin 2 genome. Since the use of OPV2 made of Sabin 2 strain has bee
Externí odkaz:
https://doaj.org/article/79f99a211a2e4e0eab6bbd00e3ad4003
Autor:
Trent J Bosma, Konstantinos Karagiannis, Luis Santana-Quintero, Natalia Ilyushina, Tatiana Zagorodnyaya, Svetlana Petrovskaya, Majid Laassri, Raymond P Donnelly, Steven Rubin, Vahan Simonyan, Christian J Sauder
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216944 (2019)
Most viruses are known to spontaneously generate defective viral genomes (DVG) due to errors during replication. These DVGs are subgenomic and contain deletions that render them unable to complete a full replication cycle in the absence of a co-infec
Externí odkaz:
https://doaj.org/article/21d18c0f908a4ec790262c8d12cf6b0a