Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Majella E. Lane"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1075 (2023)
The evaluation of bioequivalence (BE) for topical dermatological drug products is challenging, and there has been significant interest from regulatory authorities in developing new BE methodologies in recent years. Currently, BE is demonstrated by co
Externí odkaz:
https://doaj.org/article/e13812a4cb4a4605b093a35c50548c47
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2106 (2022)
Previously, we reported the use of confocal Raman spectroscopy (CRS) as a novel non-invasive approach to determine drug disposition in the skin in vivo. Results obtained by CRS were found to correlate with data from the well-established in vitro perm
Externí odkaz:
https://doaj.org/article/7000633def484aaf9fc0e2e2ec8b1024
Autor:
Annisa Rahma, Majella E. Lane
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 433 (2022)
A good understanding of infant skin should provide a rationale for optimum management of the health of this integument. In this review, we discuss the skin barrier function of infants, particularly with reference to the use of diapers and baby wipes.
Externí odkaz:
https://doaj.org/article/2b66a7e03aa34a2893b5ba03bf2806e1
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
l-ascorbic acid (AA), commonly known as vitamin C, has been widely used in topical formulations for many years as an antioxidant and anti-aging ingredient. However, the physicochemical properties of AA are not optimal for skin uptake and the molecule
Externí odkaz:
https://doaj.org/article/16819342b5bb419ba3745e304aa3d526
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 909 (2021)
Ion pairing is a strategy used to increase the permeation of topically applied ionised drugs. Formation occurs when the electrostatic energy of attraction between oppositely charged ions exceeds their mean thermal energy, making it possible for them
Externí odkaz:
https://doaj.org/article/a645bc8fc27d4be3964602678a9df0a1
Autor:
Yanling Zhang, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, Majella E. Lane
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 726 (2021)
In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell stu
Externí odkaz:
https://doaj.org/article/343038c89e20443cbd67af949b1bd387
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 542 (2021)
The composition of topical and transdermal formulations is known to determine the rate and the extent of drug delivery to and through the skin. However, to date, the role of excipients in these formulations on skin delivery of actives has received li
Externí odkaz:
https://doaj.org/article/f866b4957ce24cc196e41f830f0e66ce
Publikováno v:
Pharmaceutics, Vol 12, Iss 9, p 887 (2020)
Previously, we reported the use of Confocal Raman Spectroscopy (CRS) to investigate the topical delivery of actives and excipients. We have also correlated the results from CRS with findings from in vitro diffusion studies in human skin. However, unt
Externí odkaz:
https://doaj.org/article/98ac06e7fe114fbe9fa856fe4af2c936
Autor:
Fotis Iliopoulos, A. S. M. Monjur Al Hossain, Bruno C. Sil, David J. Moore, Robert A. Lucas, Majella E. Lane
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 2, p 19 (2020)
3-O-ethyl l-ascorbic acid (EA), an ether derivative of Vitamin C, is widely used in skincare formulations. Previously, we reported the effects of neat solvents on EA percutaneous absorption and observed that 0.6–7.5% of the applied EA was delivered
Externí odkaz:
https://doaj.org/article/6cd2de7968e8417cb1f8dc2138f441ee
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating
Externí odkaz:
https://doaj.org/article/e908199c35a64f6a9753cbd647205b2a