Výsledky vyhledávání - "Majed M, Hamawy"

Selenium-Binding Protein-1 in Smooth Muscle Cells is Downregulated in a Rhesus Monkey Model of Chronic Allograft Nephropathy

Autor: John H. Fechner, Hyoung Tae Kim, Tara L. Scheunemann, Huaizhong Hu, Tausif Alam, Jose R. Torrealba, Majed M. Hamawy, Matthew Colburn, Susan Golner, Turan Kanmaz, Zhen Chang, Terry D. Oberley, Stuart J. Knechtle, Drew A. Roenneburg

Publikováno v: American Journal of Transplantation. 5:58-67

Treating patients with kidney failure by organ transplantation has been extraordinarily successful. Although, current immunosuppressants have improved short-term allograft survival, most transplants are eventually lost due to chronic allograft nephro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6179381a9ef41c4f5a6cc3faed04c627
https://doi.org/10.1111/j.1600-6143.2004.00651.x

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Metastable Tolerance to Rhesus Monkey Renal Transplants Is Correlated with Allograft TGF-β1+CD4+ T Regulatory Cell Infiltrates

Autor: Terry D. Oberley, Majed M. Hamawy, Jose R. Torrealba, Qingyong Xu, William J. Burlingham, Jacqueline M. Schultz, S Kusaka, Gaby G. M. Doxiadis, Margreet Jonker, Ronald E. Bontrop, Masaaki Katayama, John H. Fechner, Ewa Jankowska-Gan, Jacqueline Wubben, Huaizhong Hu, Stuart J. Knechtle

Publikováno v: The Journal of Immunology. 172:5753-5764

Approaches that prevent acute rejection of renal transplants in a rhesus monkey model were studied to determine a common mechanism of acceptance. After withdrawal of immunosuppression, all 14 monkeys retained normal allograft function for >6 mo. Of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72569bdc577a9d59e1982ca806811fe4
https://doi.org/10.4049/jimmunol.172.9.5753

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Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model1

Autor: Yinchen Dong, Jacqueline M. Schultz, Debra D. Bloom, Masaaki Katayama, Terry D. Oberley, Stuart J. Knechtle, Walter Schuler, Turan Kanmaz, Huaizhong Hu, John H. Fechner, Wasim A. Dar, Jose R. Torrealba, Majed M. Hamawy, Judit Markovits, Hyoung Tae Kim

Publikováno v: Transplantation. 77:914-920

Background.This study assesses the safety and efficacy of the novel human anti-human CD154 monoclonal antibody ABI793 in rhesus monkeys.Methods.Outbred rhesus monkeys were used for renal transplantation from major histocompatibility complex-mismatche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::582d78dc43482a572fd70377143f4c4f
https://doi.org/10.1097/01.tp.0000116392.72152.75

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Elektronická kniha

IgE Receptor (FcεRI) Function in Mast Cells and Basophils

Autor: Majed M. Hamawy

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of aller

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An overview of the actions of cyclosporine and FK506

Autor: Majed M. Hamawy, Stuart J. Knechtle

Publikováno v: Transplantation Reviews. 17:165-171

Cyclosporine and FK506 are immunosuppressive drugs that have been extremely useful for treating graft-versus-host disease and autoimmune and inflammatory diseases, and they have truly revolutionized allograft transplantation. These drugs exert at lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eb682b4fc40bd60156d242c833af904
https://doi.org/10.1016/s0955-470x(03)00039-9

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Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study

Autor: Jon S. Odorico, Hans W. Sollinger, Andreas Friedl, John H. Fechner, Bryan N. Becker, Majed M. Hamawy, John D. Pirsch, Anthony M. D'Alessandro, Yolanda T. Becker, Robert B. Colvin, L. Thomas Chin, Stuart J. Knechtle, Debra D. Bloom, Lauralynn K. Lebeck, Munci Kalayoglu, Huaizhong Hu

Publikováno v: American Journal of Transplantation. 3:722-730

Campath-1H, an anti-CD52 monoclonal antibody, was used as induction therapy (40 mg i.v. total dose) in 29 primary human renal transplants, and the patients were maintained on rapamycin monotherapy (levels 8-15 ng/mL) post-transplant. Campath-1H profo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee6433c642d87c738c937441a5bee78
https://doi.org/10.1034/j.1600-6143.2003.00120.x

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Targeting proximal T cell receptor signaling in transplantation

Autor: Majed M. Hamawy

Publikováno v: Transplantation. 75:1921-1927

In the past two decades, an immense amount of information has been generated on the mechanism of T cell receptor (TCR) signaling (also called signal 1). This overview describes the major signalling pathways in the TCR signal transduction cascade and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c53cd44a39d7a3cca56846956c87f2b
https://doi.org/10.1097/01.tp.0000070168.42915.47

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Piceatannol in combination with low doses of cyclosporine a prolongs kidney allograft survival in a stringent rat transplantation model1,2

Autor: John H. Fechner, Turan Kanmaz, Huaizhong Hu, Masahiro Tsuchida, Yinchen Dong, Matthew Colburn, Jose R. Torrealba, Hyoung Tae Kim, Terry D. Oberley, Majed M. Hamawy, Stuart J. Knechtle, Jackie Schultz, Luis A. Fernandez, Nobuhiro Ishido, Gokhan Yagci

Publikováno v: Transplantation. 74:1609-1617

Background. The discovery of new immunosuppressive agents has enhanced short-term graft survival. However, current immunosuppressants often induce toxicities that limit their clinical use. Thus, there is a need for new immunosuppressants for use in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33bcb53c5b4e02ea45deb3dbe66c216f
https://doi.org/10.1097/00007890-200212150-00020

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Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation

Autor: Clifford S. Cho, Jr. and John H. Fechner, Huaizhong Hu, Majed M. Hamawy, Stuart J. Knechtle

Publikováno v: Immunological Reviews. 183:205-213

Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ddcaf6d64aecc0686e639556372f451
https://doi.org/10.1034/j.1600-065x.2001.1830116.x

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IMMUNOTOXIN FN18-CRM9 INDUCES STRONGER T CELL SIGNALING THAN UNCONJUGATED MONOCLONAL ANTIBODY FN1812

Autor: Masahiro Tsuchida, Majed M. Hamawy, John H. Fechner, Stuart J. Knechtle, Eric R. Manthei, Clifford S. Cho

Publikováno v: Transplantation. 72:496-503

Background. The T-cell receptor (TCR)/CD3 complex is the target of therapeutic strategies aimed at prolonging allograft survival. The immunotoxin FN18-CRM9, composed of the anti-CD3 monoclonal antibody FN18 and the mutated diphtheria toxin CRM9, is u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3decdba50180fd8b8cc5a376eec8198
https://doi.org/10.1097/00007890-200108150-00023

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