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pro vyhledávání: '"Majdi M. Kabaha"'
Autor:
Wasif Al-Shareef, Yogev Brown, Christopher Bryan, Elena Shuvaeva, Shhadeh Bsoul, Raanan Greenman, Majdi M. Kabaha, Nikolai B. Ulyanov, Emmanuel Skordalakes, Yehuda Tzfati
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10757 (2022)
The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus compens
Externí odkaz:
https://doaj.org/article/00b3502e00e04f59b907a940da7093aa
Autor:
Wasif, Al-Shareef, Yogev, Brown, Christopher, Bryan, Elena, Shuvaeva, Shhadeh, Bsoul, Raanan, Greenman, Majdi M, Kabaha, Nikolai B, Ulyanov, Emmanuel, Skordalakes, Yehuda, Tzfati
Publikováno v:
International journal of molecular sciences. 23(18)
The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus compens
Autor:
Majdi M. Kabaha, Yehuda Tzfati
Publikováno v:
Current Genetics. 67:153-163
Telomeres are specialized nucleoprotein complexes that protect the ends of eukaryotic chromosomes and distinguish them from broken DNA ends. Disruption of telomere protection may cause aging-associated pathologies and cancer. Here, we examined what m
Publikováno v:
Molecular and Cellular Biology. 28:1875-1882
Telomerase is a ribonucleoprotein reverse transcriptase that copies a short template within its integral telomerase RNA moiety (TER) onto eukaryotic chromosome ends, thus compensating for incomplete replication and degradation. The highly divergent y
Publikováno v:
Nucleic Acids Research
The telomerase ribonucleoprotein copies a short template within its integral RNA moiety onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Non-template regions of telomerase RNA (TER) are also crucial for telome
Publikováno v:
Chromosoma. 121(6)
In most eukaryotes, telomeres are composed of tandem arrays of species-specific DNA repeats ending with a G-rich 3' overhang. In budding yeast, Cdc13 binds this overhang and recruits Ten1-Stn1 and the telomerase protein Est1 to protect (cap) and elon