Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers

Autor: Aasly, Jan, Johansen, Krisztina, Brønstad, Gunnar, Warø, Bjørg Johanne, Majbour, NK, Varghese, S, Alzahmi, F, Paleologou, KE, Amer, DAM, Al-Hayani, A, El-Agnaf, OMA

Externí odkaz: http://hdl.handle.net/11250/2627057

Retraction Notice to: Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.

Autor: Javed H, Menon SA, Al-Mansoori KM, Al-Wandi A, Majbour NK, Ardah MT, Varghese S, Vaikath NN, Haque ME, Azzouz M, El-Agnaf OM

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Jun 05; Vol. 32 (6), pp. 2034. Date of Electronic Publication: 2024 Apr 11.

Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.

Autor: Hmila I; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Vaikath NN; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Majbour NK; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Erskine D; Translational and Clinical Research Institute, Newcastle University, UK., Sudhakaran IP; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Gupta V; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Ghanem SS; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Islam Z; Diabetes Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Emara MM; Basic Medical Sciences Department, College of Medicine, QU Health, Qatar University, Doha, Qatar.; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar., Abdesselem HB; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Kolatkar PR; Diabetes Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Achappa DK; Equine Veterinary Medical Center, Qatar Foundation, Doha, Qatar., Vinardell T; Equine Veterinary Medical Center, Qatar Foundation, Doha, Qatar.; College of Health & Life Science, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar., El-Agnaf OMA; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.

Publikováno v: The FEBS journal [FEBS J] 2022 Aug; Vol. 289 (15), pp. 4657-4673. Date of Electronic Publication: 2022 Feb 25.

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans.

Autor: Chen KS; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Menezes K; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Rodgers JB; Donnelly Centre, University of Toronto, Toronto, ON, Canada., O'Hara DM; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Tran N; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Fujisawa K; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Ishikura S; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Khodaei S; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Chau H; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Cranston A; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kapadia M; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Pawar G; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Ping S; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Krizus A; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Lacoste A; BenevolentAI, New York, NY, USA., Spangler S; IBM Research-Almaden, San Jose, CA, USA., Visanji NP; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Marras C; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Majbour NK; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., El-Agnaf OMA; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Lozano AM; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada., Culotti J; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Suo S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Ryu WS; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Physics, University of Toronto, Toronto, ON, Canada., Kalia SK; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.; KITE and CRANIA, University Health Network, Toronto, ON, Canada., Kalia LV; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2021 Nov 12; Vol. 16 (1), pp. 77. Date of Electronic Publication: 2021 Nov 12.

Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort.

Autor: Smith M; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Abdesselem HB; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.; Proteomics Core Facility, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar., Mullins M; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Tan TM; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Nel AJM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Al-Nesf MAY; Hamad General Hospital, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar., Bensmail I; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar., Majbour NK; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar., Vaikath NN; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar., Naik A; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar., Ouararhni K; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar., Mohamed-Ali V; Anti-Doping Laboratory Qatar, Sports City Road, Aspire Zone, Doha P.O. Box 27775, Qatar., Al-Maadheed M; Anti-Doping Laboratory Qatar, Sports City Road, Aspire Zone, Doha P.O. Box 27775, Qatar., Schell DT; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Baros-Steyl SS; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Anuar ND; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Ismail NH; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Morris PE; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Mamat RNR; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Rosli NSM; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Anwar A; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia., Ellan K; Virology Lab, Level 2, Block C7, Infectious Disease Research Centre, Institute for Medical Research, Setia Alam, Selangor 40170, Malaysia., Zain RM; Virology Lab, Level 2, Block C7, Infectious Disease Research Centre, Institute for Medical Research, Setia Alam, Selangor 40170, Malaysia., Burgers WA; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town 7925, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa., Mayne ES; Department of Immunology, National Health Laboratory Service (NHLS) and University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg 2196, South Africa., El-Agnaf OMA; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar., Blackburn JM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.; Sengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.

Publikováno v: Viruses [Viruses] 2021 Apr 28; Vol. 13 (5). Date of Electronic Publication: 2021 Apr 28.