Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Maja S, Engelstoft"'
Autor:
Kaare V. Grunddal, Sarah Tonack, Kristoffer L. Egerod, Jonathan James Thompson, Natalia Petersen, Maja S. Engelstoft, Constance Vagne, Céline Keime, Gérard Gradwohl, Stefan Offermanns, Thue W. Schwartz
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101231- (2021)
Objective: GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation aimed to delineate the cellular expression of GPR64 throughout the body with focu
Externí odkaz:
https://doaj.org/article/7ee8630e8aa2483798aecb86304f3a04
Autor:
Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 24-39 (2019)
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controllin
Externí odkaz:
https://doaj.org/article/ae5bc94129d345d5a7f7ab5313070cd2
Autor:
Mari L. Lund, Kristoffer L. Egerod, Maja S. Engelstoft, Oksana Dmytriyeva, Elvar Theodorsson, Bhavik A. Patel, Thue W. Schwartz
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 70-83 (2018)
Objectives: 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract. Howev
Externí odkaz:
https://doaj.org/article/973b0545f5a14535b363aa036d4ce68f
Autor:
Mette M. Rosenkilde, Stella Feng Sheng Xu, Sara L. Jepsen, Cathrine Ørskov, Rune E. Kuhre, Thue W. Schwartz, Ida M. Modvig, Maja S. Engelstoft, Jens J. Holst, Kristoffer L. Egerod
Publikováno v:
Modvig, I M, Kuhre, R E, Jepsen, S L, Xu, S, Engelstoft, M S, Egerod, K L, Schwartz, T W, Ørskov, C, Rosenkilde, M M & Holst, J J 2021, ' Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms ', American Journal of Physiology: Endocrinology and Metabolism, vol. 320, pp. E874-E885 . https://doi.org/10.1152/ajpendo.00026.2021
The aim of this study was to explore individual amino acid-stimulated GLP-1 responses and the underlying stimulatory mechanisms, as well as to identify the amino acid-sensing-receptors involved in amino acid-stimulated GLP-1 release. Experiments were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025e4c42993bed418a18b5ba1bfd913b
https://doi.org/10.1152/ajpendo.00026.2021
https://doi.org/10.1152/ajpendo.00026.2021
Autor:
Sarah Tonack, Thue W. Schwartz, Natalia Petersen, Céline Keime, Constance Vagne, Gérard Gradwohl, Jonathan James Thompson, Maja S. Engelstoft, Kristoffer L. Egerod, Stefan Offermanns, Kaare V. Grunddal
Publikováno v:
V. Grunddal, K, Tonack, S, Egerod, K L, Thompson, J J, Petersen, N, Engelstoft, M S, Vagne, C, Keinse, C, Gradwohl, G, Offermanns, S & Schwartz, T W 2021, ' Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells ', Molecular Metabolism, vol. 51, 101231 . https://doi.org/10.1016/j.molmet.2021.101231
Molecular metabolism
Molecular metabolism, 2021, 51, ⟨10.1016/j.molmet.2021.101231⟩
Molecular Metabolism, Vol 51, Iss, Pp 101231-(2021)
Molecular metabolism
Molecular metabolism, 2021, 51, ⟨10.1016/j.molmet.2021.101231⟩
Molecular Metabolism, Vol 51, Iss, Pp 101231-(2021)
Objective: GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation aimed to delineate the cellular expression of GPR64 throughout the body with focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dc901ce96c3307e57d9fc46b762068
https://doi.org/10.1016/j.molmet.2021.101231
https://doi.org/10.1016/j.molmet.2021.101231
Autor:
Thue W. Schwartz, Maja S. Engelstoft, Andreas N. Madsen, Pascal Timshel, Jeppe P. Ekberg, Maria Hauge
Publikováno v:
Molecular and Cellular Endocrinology. 449:64-73
GPR40 is generally known to signal through Gq. However, in transfected cells, certain synthetic agonists can make the receptor signal also through Gs and cAMP (Hauge et al., 2015). Here we find that, in colonic crypt cultures, the GLP-1 secretion ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f62573f3620dd2c248762fe3ab9576
https://doi.org/10.1016/j.mce.2016.11.024
https://doi.org/10.1016/j.mce.2016.11.024
Autor:
Kristoffer L. Egerod, Anne-Sofie Graae, Thue W. Schwartz, Birgitte Holst, Rie Nygaard, Thomas M. Frimurer, Franziska Mende, Lars-Ole Gerlach, Jakob Bondo Hansen, Maja S. Engelstoft
Publikováno v:
Journal of Medicinal Chemistry. 60:886-898
The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn2+. We used a homology model-based approach to identify small-molecule pharmacological tool compounds for the receptor. The method focused on a putative binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba90f1ff175e77740028a4bed824ec7
https://doi.org/10.1021/acs.jmedchem.6b00648
https://doi.org/10.1021/acs.jmedchem.6b00648
Autor:
Rainer E. Martin, Andreas D. Christ, Maja S. Engelstoft, Steen Seier Poulsen, Mette M. Rosenkilde, Elisa P. Jensen, Nicolai J. Wewer Albrechtsen, Frank Reimann, Jens Pedersen, Thue W. Schwartz, Cathrine Ørskov, Kaare V. Grunddal, Jens J. Holst, Sara L. Jepsen, Maria Buur Nordskov Gabe, Fiona M. Gribble, Carolyn F. Deacon
Publikováno v:
Am J Physiol Endocrinol Metab
DPP-4 inhibitors, used for treatment of type 2 diabetes, act by increasing the concentrations of intact glucagon-like peptide-1 (GLP-1), but at the same time, they inhibit secretion of GLP-1, perhaps by a negative feedback mechanism. We hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b98c252e3a8a6e863df3f30d49e8933
https://pubmed.ncbi.nlm.nih.gov/31503512
https://pubmed.ncbi.nlm.nih.gov/31503512
Autor:
Thue W. Schwartz, Julie Piccand, Adèle De Arcangelis, Nacho Molina, Mari L. Lund, Anthony Beucher, Sabitri Ghimire, Florence Blot, Valérie Schreiber, Sara Jimenez Correa, Christelle Thibault-Carpentier, Maja S. Engelstoft, Aline Meunier, Céline Lapp, Constance Vagne, Gérard Gradwohl, Perrine Strasser, Céline Keime, Laure Nivlet, Natalia Petersen
Publikováno v:
Piccand, J, Vagne, C, Blot, F, Meunier, A, Beucher, A, Strasser, P, Lund, M L, Ghimire, S, Nivlet, L, Lapp, C, Petersen, N, Engelstoft, M S, Thibault-Carpentier, C, Keime, C, Correa, S J, Schreiber, V, Molina, N, Schwartz, T W, De Arcangelis, A & Gradwohl, G 2019, ' Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production ', Molecular Metabolism, vol. 29, pp. 24-39 . https://doi.org/10.1016/j.molmet.2019.08.007
Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2019, 29, pp.24-39. ⟨10.1016/j.molmet.2019.08.007⟩
Molecular Metabolism, Vol 29, Iss, Pp 24-39 (2019)
Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2019, 29, pp.24-39. ⟨10.1016/j.molmet.2019.08.007⟩
Molecular Metabolism, Vol 29, Iss, Pp 24-39 (2019)
Objective Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controlling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e444c342773de6de0b4168342183cc0
https://curis.ku.dk/portal/da/publications/rfx6-promotes-the-differentiation-of-peptidesecreting-enteroendocrine-cells-while-repressing-genetic-programs-controlling-serotonin-production(90f1beda-b090-460a-a08a-d4c307dbc5be).html
https://curis.ku.dk/portal/da/publications/rfx6-promotes-the-differentiation-of-peptidesecreting-enteroendocrine-cells-while-repressing-genetic-programs-controlling-serotonin-production(90f1beda-b090-460a-a08a-d4c307dbc5be).html
Autor:
Birgitte Holst, Anna-Sofie Husted, Jeppe H. Ekberg, Thue W. Schwartz, Frank Reiman, Line Vildbrad Kristensen, Kristoffer L. Egerod, Fiona M. Gribble, Maja S. Engelstoft, Timothy J. Kowalski, Rasmus M. Sichlau, Harald S. Hansen, Andrew D. Howard, Andreas N. Madsen, Pascal Timshel, Maria Hauge
Publikováno v:
Endocrinology
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G Protein-coupled Receptor [GPR] 40), FFA4 (GPR120), and GPR119, which all recognize TG metabolites, ie, long-chain fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ae0d1437150d615f8bf8b5855f4d43
https://doi.org/10.1210/en.2016-1334
https://doi.org/10.1210/en.2016-1334