Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Maja M Janas"'
Autor:
Maja M Janas, Mehdi Khaled, Steffen Schubert, Jacob G Bernstein, David Golan, Rosa A Veguilla, David E Fisher, Noam Shomron, Carmit Levy, Carl D Novina
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002330 (2011)
The majority of mammalian microRNA (miRNA) genes reside within introns of protein-encoding and non-coding genes, yet the mechanisms coordinating primary transcript processing into both mature miRNA and spliced mRNA are poorly understood. Analysis of
Externí odkaz:
https://doaj.org/article/4f3eba0b377444649e173cfb613834ef
Autor:
Dhrubajyoti Datta, Christopher S. Theile, Kelly Wassarman, June Qin, Tim Racie, Karyn Schmidt, Yongfeng Jiang, Rachel Sigel, Maja M. Janas, Martin Egli, Muthiah Manoharan
Publikováno v:
Chemical Communications. 59:6347-6350
A new class of 5′-morpholino modified nucleoside building blocks was synthesized. Among them, Mo2 exhibited better off-target mitigation for RNAi compared to other analogues Pip and Mo3 and the previously reported morpholino derivative Mo1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23600fd29558f2adace7845aeaf52ce0
https://doi.org/10.1039/d3cc01143g
https://doi.org/10.1039/d3cc01143g
Autor:
Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga-Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie D. Keirstead, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A subset of chemically-modified siRNAs conjugated to trivalent GalNAc may fail during nonclinical development due to rat hepatotoxicity. Here, the authors show that hepatotoxicity may be accounted for by microRNA-like off-target effects of siRNA and
Externí odkaz:
https://doaj.org/article/c6e811a8256f42f19ee8c93f99cf1382
Autor:
Dale C. Guenther, Shohei Mori, Shigeo Matsuda, Jason A. Gilbert, Jennifer L. S. Willoughby, Sarah Hyde, Anna Bisbe, Yongfeng Jiang, Saket Agarwal, Mimouna Madaoui, Maja M. Janas, Klaus Charisse, Martin A. Maier, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of the American Chemical Society. 144:14517-14534
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bbffe6abbd1ffd5c3b0eef69bdf8ab9
https://doi.org/10.1021/jacs.2c01679
https://doi.org/10.1021/jacs.2c01679
Autor:
Sarah Bond, Saeho Chong, Tuyen Nguyen, Justin Darcy, Saket Agarwal, Maja M. Janas, Jing-Tao Wu, Samantha Chigas, Yongli Gu, Ruth Allard
Publikováno v:
Nucleic Acid Therapeutics
Serum protein interactions are evaluated during the drug development process since they determine the free drug concentration in blood and thereby can influence the drug's pharmacokinetic and pharmacodynamic properties. While the impact of serum prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03774b8b68b07398a9b85a3521e562f
https://doi.org/10.1089/nat.2020.0919
https://doi.org/10.1089/nat.2020.0919
Autor:
Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu
Publikováno v:
Drug Metabolism and Disposition. 50:781-797
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs) or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has become the primary strategy for hepatocyte-targeted delivery, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4ae67a6f9cc6256cba922321905899
https://doi.org/10.1124/dmd.121.000428
https://doi.org/10.1124/dmd.121.000428
Autor:
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
Publikováno v:
Nucleic acids research. 50(12)
Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we demonstrate that a single glycol nucleic acid or 2′–5′-RNA modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2a858ced9155dfb1611847e3c71ffc
https://pubmed.ncbi.nlm.nih.gov/35736224
https://pubmed.ncbi.nlm.nih.gov/35736224
Autor:
Mark K Schlegel, Derek K O'Flaherty, Maja M. Janas, Jason A. Gilbert, Namrata D. Erande, Ivan Zlatev, Shigeo Matsuda, Yongfeng Jiang, June Qin, Pawan Kumar, Rohan Degaonkar, Martha Mendez, Masaaki Akabane-Nakata, Muthiah Manoharan, Martin Egli, Lauren Blair Woods
Publikováno v:
Nucleic Acids Research
We recently reported the synthesis of 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides, which are based on a bicyclo[3.1.0]hexane scaffold. Here, we analyzed RNAi-mediated gene silencing activity in cell culture and demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb126446218275cc4c49a137866dae30
https://doi.org/10.1093/nar/gkab050
https://doi.org/10.1093/nar/gkab050
Autor:
Pawan Kumar, Piet Herdewijn, Joel M. Harp, Ivan Zlatev, Muthiah Manoharan, Marie Capobianco, Martin Egli, Mark K Schlegel, Mikhail Abramov, Maja M. Janas, Charalambos Kaittanis, Yongfeng Jiang, Adam Castoreno, Rohan Degaonkar, Dale C. Guenther, Guy Schepers
Publikováno v:
Nucleic Acids Research
In this report, we investigated the hexopyranose chemical modification Altriol Nucleic Acid (ANA) within small interfering RNA (siRNA) duplexes that were otherwise fully modified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ae4e4bbfa9566887fc414d31094d1c
https://doi.org/10.1093/nar/gkaa125
https://doi.org/10.1093/nar/gkaa125
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
