Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Maja Lambert"'
Autor:
Mark D. Andrews, Kevin N. Dack, Marcel J. de Groot, Maja Lambert, Carl J. Sennbro, Mogens Larsen, Martin Stahlhut
Publikováno v:
Journal of Medicinal Chemistry. 65:8828-8842
Interleukin 17A (IL-17A) is an interleukin cytokine whose dysregulation is implicated in autoimmune disorders such as psoriasis, and monoclonal antibodies against the IL-17A pathway are now well-established and very effective treatments. This article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d2334f68390f08242878bf8c7d2e05
https://doi.org/10.1021/acs.jmedchem.2c00422
https://doi.org/10.1021/acs.jmedchem.2c00422
Autor:
Ivaylo Jivkov Elenkov, Simon Feldbaek Nielsen, Kristina Butković, Sanja Koštrun, Dijana Pesic, Dack Kevin Neil, Tine Skak-Nielsen, Dinko Žiher, Martin Stahlhut, Adriana Petrinić Grba, Vlatka Bencetić Mihaljević, Ana Čikoš, Samra Kapić, Andrea Fajdetić, Renata Rupčić, Gordon Saxty, Maja Lambert, Jasna Padovan, Ivana Ozimec Landek, Karmen Brajša, Dubravko Jelić, Haakan Bladh, Ana Grgičević
Publikováno v:
Journal of Medicinal Chemistry. 64:8354-8383
Interleukin 17 (IL-17) cytokines promote inflammatory pathophysiology in many autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Such broad involvement of IL-17 in various autoimmune di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05f28315da0be7107038b135d157e95
https://doi.org/10.1021/acs.jmedchem.1c00327
https://doi.org/10.1021/acs.jmedchem.1c00327
Autor:
Thomas Vifian, Tatiana G Stilou, Simon Feldbaek Nielsen, Maja Lambert, Jens Christian Højland Larsen, Tine Skak-Nielsen, Anders Soehoel, Pontus Hegardt, Lene M. Hansen, Nina Østergaard Knudsen, Morten Dahl Sørensen, Mogens Larsen, Cecilia Eskilsson, Steen Laursen, Stefan Eirefelt, Henrik Pettersson, Anna Ollerstam
Publikováno v:
Journal of Medicinal Chemistry. 63:14502-14521
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb38d7abc4b9986a9e38e75c9c4ae01
https://doi.org/10.1021/acs.jmedchem.0c00797
https://doi.org/10.1021/acs.jmedchem.0c00797
Autor:
Gitte Pommergaard Pedersen, Line Hollesen Schefe, Manfred Bodenlenz, Christian Janfelt, Frank Sinner, Stefan Eirefelt, André Huss Eriksson, Thomas Birngruber, Maja Lambert, Anne Mette Handler, Fredrik Johansson, Kim Troensegaard Nielsen, Nina Østergaard Knudsen
Publikováno v:
Handler, A M, Eirefelt, S, Lambert, M, Johansson, F, Hollesen Schefe, L, Knudsen, N Ø, Bodenlenz, M, Birngruber, T, Sinner, F, Eriksson, A H, Pedersen, G P, Janfelt, C & Troensegaard Nielsen, K 2021, ' Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging ', Molecular Pharmaceutics, vol. 18, no. 8, pp. 3063-3072 . https://doi.org/10.1021/acs.molpharmaceut.1c00285
Traditionally, cutaneous drug delivery is studied by skin accumulation or skin permeation, while alternative techniques may enable the interactions between the drug and the skin to be studied in more detail. Time-resolved skin profiling for pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afaf40a0d690fd7ebd85237ac597828
https://curis.ku.dk/ws/files/336199777/MolecularPharmaceutics18_3063_3072_2021_preprint.pdf
https://curis.ku.dk/ws/files/336199777/MolecularPharmaceutics18_3063_3072_2021_preprint.pdf
Autor:
Maja Lambert, Stefan Eirefelt, Simon Feldbaek Nielsen, Malene Bertelsen, Jens Christian Højland Larsen, Thomas Birngruber, Frank Sinner, Fredrik Johansson, Joanna Hummer, Line Hollesen Basse
Publikováno v:
Pharmaceutical Research. 37
To investigate the difference in clinical efficacy in AD patients between two topical PDE4 inhibitors using dermal open flow microperfusion and cAMP as a pharmacodynamic read-out in fresh human skin explants. Clinical formulations were applied to int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed590dba8addf44cffbacdc91079596c
https://doi.org/10.1007/s11095-020-02962-1
https://doi.org/10.1007/s11095-020-02962-1
Autor:
Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen
Publikováno v:
Journal of medicinal chemistry. 63(23)
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91d778dd5cf2a7a2234d7f9358d53149
https://pubmed.ncbi.nlm.nih.gov/33054196
https://pubmed.ncbi.nlm.nih.gov/33054196
Publikováno v:
Amino Acids. 34:465-471
N-alkyl-beta-alanine oligomers (beta-peptoids) with alpha-chiral side chains [(R)- or (S)-1-(phenylethyl)amino groups] were synthesized and analyzed by CD spectroscopy. These chiral beta-peptoid homomers exhibited chain-length-dependent and solvent-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2a40a563d8a9d84cc1c607da29e27b
https://doi.org/10.1007/s00726-007-0546-8
https://doi.org/10.1007/s00726-007-0546-8
Publikováno v:
Journal of Natural Products. 68:1500-1509
A novel hyphenated technique, HPLC-SPE-NMR, was used for accelerated identification of isoflavonoids from the roots of Smirnowia iranica. The extract constituents eluted from a HPLC column were automatically trapped on solid-phase extraction (SPE) ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a792cbd741b80f7f4ed6c8dac4c1a5
https://doi.org/10.1021/np0502037
https://doi.org/10.1021/np0502037
Autor:
Javad Asili, Maja Lambert, Hanne L Ziegler, Jerzy W. Jaroszewski, Ismaiel S Ibrahimi, Matthias Witt, Majid Sairafianpour, Dan Staerk, Gholamreza Asghari
Publikováno v:
Journal of Natural Products. 67:631-637
Six labdanes (1-6) and four isopimaranes (7-10), including three new natural products (7, 9, and 10), were isolated from Platycladus orientalis, and their structures determined using 1D and 2D NMR methods, ion-cyclotron resonance HRMS, and optical ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7a9dde58c6901f6c95bb2634631411
https://doi.org/10.1021/np034033e
https://doi.org/10.1021/np034033e
Publikováno v:
Medicinal Plant Biotechnology: From Basic Research to Industrial Applications
University of Copenhagen
University of Copenhagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c779ed7f575f398302b32969d375a953
https://doi.org/10.1002/9783527619771.ch3
https://doi.org/10.1002/9783527619771.ch3