Výsledky vyhledávání - "Maja Buerdek"

A new chapter for the COVID-19 pandemic – and for the vaccines space

Autor: Gary Waanders, Petra Prinz-Schulz, Maja Buerdek, Silke Raffegerst

Publikováno v: Vaccine Insights. 1:107-110

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::004c7badd8c4de0321e8da91e9cd53f7
https://doi.org/10.18609/cgti.2021.017

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Abstract 4057: T cells co-expressing a highly potent NY-ESO-1-specific TCR and a chimeric PD1-41BB co-stimulatory switch receptor show a favorable polyfunctional profile for the treatment of solid tumors

Autor: Andrea Coluccio, Stefanie Tippmer, Petra Prinz, Maja Buerdek, Kathrin Mutze, Barbara Loesch, Kathrin Davari, Giulia Longinotti, Dolores J. Schendel

Publikováno v: Cancer Research. 83:4057-4057

T cell receptor (TCR)-based immunotherapies have shown great potential for the safe and efficacious treatment of patients suffering from various solid malignancies. However, novel strategies are needed to overcome the immunosuppressive tumor microenv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfff739fbccc53bb0aad582e1f20ae0c
https://doi.org/10.1158/1538-7445.am2023-4057

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Abstract 3231: The chimeric co-stimulatory receptor PD1-41BB enhances the function of T cell receptor (TCR)-modified T cells targeting solid tumors

Autor: Dolores J. Schendel, Nadja Sailer, Angelika J. Fischbeck, Sarah Thome, Elfriede Noessner, Patrik Kehler, Maria Gerget, Melanie Salvermoser, Maja Buerdek, Christian Ellinger, Luis Felipe Olguín-Contreras, Svenja Ruehland

Publikováno v: Cancer Research. 80:3231-3231

Introduction: The use of cellular immunotherapies has led to impressive complete and durable clinical responses in patients with certain types of hematological cancers. However, positive clinical results in solid tumor indications are still rare and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55c323fdf1e20970fb295325324e5ae3
https://doi.org/10.1158/1538-7445.am2020-3231

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Abstract 2303: In vitro evaluation of TCR efficacy and toxicity using 3D spheroid models

Autor: Kathrin Mutze, Maja Buerdek, Kai Pinkernell, Dolores J. Schendel

Publikováno v: Cancer Research. 79:2303-2303

Clinical studies using TCR-transgenic T cells for adoptive T cell therapy revealed the efficacy of this therapeutic approach but also uncovered possible toxic effects against healthy tissues, such as neuronal or cardiac cells, caused by on-target/off

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cf21c407eeb776d694170c0a0bf8025
https://doi.org/10.1158/1538-7445.am2019-2303

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