Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Maja Bućan"'
Autor:
Shuzhang Yang, Kai Wang, Brittany Gregory, Wade Berrettini, Li-San Wang, Hakon Hakonarson, Maja Bucan
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4474 (2009)
Bipolar disorder (BPD) is a common psychiatric illness with a complex mode of inheritance. Besides traditional linkage and association studies, which require large sample sizes, analysis of common and rare chromosomal copy number variants (CNVs) in e
Externí odkaz:
https://doaj.org/article/aae866f137c54bfc823f2733bc572284
Autor:
Kelly Finke, Michael Kourakos, Gabriela Brown, Huyen Trang Dang, Shi Jie Samuel Tan, Yuval B Simons, Shweta Ramdas, Alejandro A Schäffer, Rachel L Kember, Maja Bućan, Sara Mathieson
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008638 (2021)
In this work we develop a novel algorithm for reconstructing the genomes of ancestral individuals, given genotype or sequence data from contemporary individuals and an extended pedigree of family relationships. A pedigree with complete genomes for ev
Externí odkaz:
https://doaj.org/article/d24f8ecd506c42678b641f010b0c029d
Autor:
Moe Nakanishi, Jun Nomura, Xiao Ji, Kota Tamada, Takashi Arai, Eiki Takahashi, Maja Bućan, Toru Takumi
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007035 (2017)
[This corrects the article DOI: 10.1371/journal.pgen.1006940.].
Externí odkaz:
https://doaj.org/article/beb153ad20ce48a98103afadcff117fc
Autor:
Moe Nakanishi, Jun Nomura, Xiao Ji, Kota Tamada, Takashi Arai, Eiki Takahashi, Maja Bućan, Toru Takumi
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006940 (2017)
Genetic mutations contribute to the etiology of autism spectrum disorder (ASD), a common, heterogeneous neurodevelopmental disorder characterized by impairments in social interaction, communication, and repetitive and restricted patterns of behavior.
Externí odkaz:
https://doaj.org/article/83b4b53600b84d8bae32a1bf0db7b363
Autor:
Benjamin Georgi, David Craig, Rachel L Kember, Wencheng Liu, Ingrid Lindquist, Sara Nasser, Christopher Brown, Janice A Egeland, Steven M Paul, Maja Bućan
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004229 (2014)
Bipolar disorder is a common, heritable mental illness characterized by recurrent episodes of mania and depression. Despite considerable effort to elucidate the genetic underpinnings of bipolar disorder, causative genetic risk factors remain elusive.
Externí odkaz:
https://doaj.org/article/1345e3e98470465ea318e2173d590b88
Publikováno v:
PLoS Genetics, Vol 9, Iss 5, p e1003484 (2013)
Understanding the core set of genes that are necessary for basic developmental functions is one of the central goals in biology. Studies in model organisms identified a significant fraction of essential genes through the analysis of null-mutations th
Externí odkaz:
https://doaj.org/article/58419f0b9fc74c90b04503a579f891e1
Autor:
Stacey D. Elkhatib Smidt, Arpita Ghorai, Sara C. Taylor, Brielle N. Gehringer, Holly C. Dow, Allison Langer, Eric Rawot, Jing Zhang, Jonathan A. Mitchell, Daniel J. Rader, Laura Almasy, Edward S. Brodkin, Maja Bućan
Publikováno v:
Autism Research. 15:641-652
Autistic children and adults often have sleep disturbances, which may affect their and their family's quality of life. Yet, the relationship between sleep-wake patterns and autism spectrum traits is understudied. Identifying such relationships could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e28de83e22a2dec9367c9fe4dc923f8
https://doi.org/10.1002/aur.2660
https://doi.org/10.1002/aur.2660
Autor:
Jing Zhang, J. Dylan Weissenkampen, Rachel L. Kember, iPSYCH Consortium, Jakob Grove, Anders D. Børglum, Elise B. Robinson, Edward S. Brodkin, Laura Almasy, Maja Bucan, Ronnie Sebro
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Positive assortative mating (AM) in several neuropsychiatric traits, including autism, has been noted. However, it is unknown whether the pattern of AM is different in phenotypically defined autism subgroups [e.g., autism with and
Externí odkaz:
https://doaj.org/article/614572123c374482bc1fe8004baf35f9
Autor:
Hang Yuan, Tatiana Plekhanova, Rosemary Walmsley, Amy C. Reynolds, Kathleen J. Maddison, Maja Bucan, Philip Gehrman, Alex Rowlands, David W. Ray, Derrick Bennett, Joanne McVeigh, Leon Straker, Peter Eastwood, Simon D. Kyle, Aiden Doherty
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Sleep is essential to life. Accurate measurement and classification of sleep/wake and sleep stages is important in clinical studies for sleep disorder diagnoses and in the interpretation of data from consumer devices for monitoring physical
Externí odkaz:
https://doaj.org/article/36ffd372308e479ea4a5dd8446781704
Autor:
Rachel L. Kember, Alison K. Merikangas, Shefali S. Verma, Anurag Verma, Renae Judy, Scott M. Damrauer, Marylyn D. Ritchie, Daniel J. Rader, Maja Bućan, Goncalo Abecasis, Aris Baras, Michael Cantor, Giovanni Coppola, Aris Economides, Luca Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Christina Beechert, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Michael Lattari, Alexander Lopez, Thomas D. Schleicher, Maria Sotiropoulos Padilla, Karina Toledo, Louis Widom, Sarah E. Wolf, Manasi Pradhan, Kia Manoochehri, Ricardo H. Ulloa, Xiaodong Bai, Suganthi Balasubramanian, Leland Barnard, Andrew Blumenfeld, Gisu Eom, Lukas Habegger, Young Hahn, Alicia Hawes, Shareef Khalid, Evan K. Maxwell, William Salerno, Jeffrey C. Staples, Ashish Yadav, Marcus B. Jones, Lyndon J. Mitnaul
Publikováno v:
Biol Psychiatry
Background Prediction of disease risk is a key component of precision medicine. Common traits such as psychiatric disorders have a complex polygenic architecture, making the identification of a single risk predictor difficult. Polygenic risk scores (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcae4d9b81d3bbf0536f99f86413b7f7
https://pubmed.ncbi.nlm.nih.gov/32919613
https://pubmed.ncbi.nlm.nih.gov/32919613