Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Maja Aleksic"'
Autor:
Erika Parkinson, Paul Skipp, Maja Aleksic, Andrew Garrow, Tony Dadd, Michael Hughes, Geraldine Clough, C David O'Connor
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97772 (2014)
BACKGROUND: Skin has a variety of functions that are incompletely understood at the molecular level. As the most accessible tissue in the body it often reveals the first signs of inflammation or infection and also represents a potentially valuable so
Externí odkaz:
https://doaj.org/article/c89a9c8156184e95877167056a827b7a
Autor:
Paul Skipp, Benjamin L. Nicholas, Erika Parkinson, Alistair Bailey, Tim Elliott, Gavin Maxwell, Rachel Darley, Maja Aleksic, Michael R. Ardern-Jones, Ying Teo
Publikováno v:
Toxicological Sciences
Skin sensitization following the covalent modification of proteins by low molecular weight chemicals (haptenation) is mediated by cytotoxic T lymphocyte (CTL) recognition of human leukocyte antigen (HLA) molecules presented on the surface of almost a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67179df82f9d38598ef29fd531085ea7
https://doi.org/10.1093/toxsci/kfaa184
https://doi.org/10.1093/toxsci/kfaa184
Autor:
Paul Skipp, Erika Parkinson, Richard Cubberley, Rachael Arthur, Sergio Regufe da Mota, Maja Aleksic
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 62
The potential risk of skin sensitisation, associated with the development of allergic contact dermatitis (ACD), is a consideration in the safety assessment of new ingredients for use in personal care products. Protein haptenation in skin by sensitisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adee393a387e372052a68170727d0b28
https://pubmed.ncbi.nlm.nih.gov/31669365
https://pubmed.ncbi.nlm.nih.gov/31669365
Publikováno v:
Toxicology. 445:152603
Haptenation of model nucleophiles, representing the key MIE in skin sensitisation, is routinely measured in chemico to provide data for skin allergy risk assessment. Better understanding of the dynamics of haptenation in human skin could provide the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeccf742104db7cdfd5edf695631b775
https://doi.org/10.1016/j.tox.2020.152603
https://doi.org/10.1016/j.tox.2020.152603
Autor:
Neil R. Kitteringham, Maja Aleksic, Dean J. Naisbitt, Sandrine Spriggs, David Sheffield, Adedamola Olayanju
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 154(1)
Glutathione (GSH) plays a major role in skin detoxification processes due to its ability to conjugate electrophilic exogenous compounds with, and sometimes without, catalysis by glutathione-s-transferase (GST). GST activity has been demonstrated both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0ba6c13d831e1651cea5a019f0a3c7
https://pubmed.ncbi.nlm.nih.gov/27492222
https://pubmed.ncbi.nlm.nih.gov/27492222
Autor:
Rosalind E. Jenkins, Claire Jenkinson, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park, Maja Aleksic
Publikováno v:
Journal of Investigative Dermatology. 130:732-742
Exposure to p -phenylenediamine (PPD) is associated with the development of T-cell-mediated allergic contact dermatitis. The purpose of this study was to define the nature of the interaction of PPD with the protein and the antigenic determinant that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fe63e5c43f332e922beb370197fad7
https://doi.org/10.1038/jid.2009.271
https://doi.org/10.1038/jid.2009.271
Autor:
Sidonie N. Lavergne, Claire Jenkinson, Clodagh M. King, Maja Aleksic, Andrew White, Munir Pirmohamed, David A. Basketter, B. Kevin Park, Camilla Pease, Eve Coulter, John Farrell, Dean J. Naisbitt, Dominic P. Williams
Publikováno v:
Journal of Investigative Dermatology. 130:161-174
Factors predisposing to individual susceptibility to contact allergic dermatitis are ill defined. This study was designed to characterize the response of allergic and tolerant individuals' T-lymphocytes after exposure to p-phenylenediamine (PPD). Per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b155dd8edd9ca1048af2f56abc4ab0f2
https://doi.org/10.1038/jid.2009.187
https://doi.org/10.1038/jid.2009.187
Autor:
Rosalind E. Jenkins, B. Kevin Park, Maja Aleksic, James L. Maggs, Dean J. Naisbitt, Claire Jenkinson, Neil R. Kitteringham
Publikováno v:
Chemical Research in Toxicology. 22:1172-1180
Exposure to the skin sensitizer p-phenylenediamine (PPD) is associated with allergic contact dermatitis; however, the ability of PPD to modify protein has not been fully investigated. The aims of this study were to characterize the reactions of PPD a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b870420e52e89f80c625c87a3b726d0
https://doi.org/10.1021/tx900095r
https://doi.org/10.1021/tx900095r
Autor:
Andrew J. P. White, Geraldine F. Clough, Maja Aleksic, Andrew G. Garrow, C. David O'Connor, Daniel J. Scott, Paul Skipp, Erika Parkinson
Publikováno v:
Journal of the American Society for Mass Spectrometry. 20:S26-S55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909809cb69452e934a595f6dbb5f413b
https://doi.org/10.1016/j.jasms.2009.03.013
https://doi.org/10.1016/j.jasms.2009.03.013
Publikováno v:
Toxicology in Vitro. 22:1169-1176
A large proportion of allergic skin reactions are considered to be the result of skin exposure to small organic chemicals that possess the intrinsic ability to covalently modify skin proteins, either directly or following activation. In the absence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a87f2aea20881d8872a93089996cde
https://doi.org/10.1016/j.tiv.2008.03.006
https://doi.org/10.1016/j.tiv.2008.03.006