Výsledky vyhledávání - "Maja, Payrits"

Akademický článek

Hemokinin-1 as a Mediator of Arthritis-Related Pain via Direct Activation of Primary Sensory Neurons

Autor: Éva Borbély, Ágnes Hunyady, Krisztina Pohóczky, Maja Payrits, Bálint Botz, Attila Mócsai, Alexandra Berger, Éva Szőke, Zsuzsanna Helyes

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. The

Externí odkaz: https://doaj.org/article/45778cb62aad4d08b8befeb81b6cb9d8

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Akademický článek

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

Autor: Ádám Horváth, Maja Payrits, Anita Steib, Boglárka Kántás, Tünde Biró-Süt, János Erostyák, Géza Makkai, Éva Sághy, Zsuzsanna Helyes, Éva Szőke

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-ordered plasma

Externí odkaz: https://doaj.org/article/45c6cb8a94de4eab8d76bbc60679ead5

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Akademický článek

Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation

Autor: Ádám Horváth, Tünde Biró-Sütő, Boglárka Kántás, Maja Payrits, Rita Skoda-Földes, Eszter Szánti-Pintér, Zsuzsanna Helyes, Éva Szőke

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and play an integrative role in pain processing and inflammatory functions. Lipid rafts are liquid-ordered pla

Externí odkaz: https://doaj.org/article/79314d3eec1a463181aac371051dcea9

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Akademický článek

Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation

Autor: Éva Sághy, Maja Payrits, Tünde Bíró-Sütő, Rita Skoda-Földes, Eszter Szánti-Pintér, János Erostyák, Géza Makkai, György Sétáló, Jr., László Kollár, Tamás Kőszegi, Rita Csepregi, János Szolcsányi, Zsuzsanna Helyes, Éva Szőke

Publikováno v: Journal of Lipid Research, Vol 59, Iss 10, Pp 1851-1863 (2018)

Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 (TRPV1) and TRP Ankyrin 1 (TRPA1), are expressed on primary sensory neurons. These thermosensor channels play a role in pain processing. We have provided evidence previously

Externí odkaz: https://doaj.org/article/275692ed1a07417d8ba4ed8ba39d772d

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Akademický článek

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Autor: Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes

Publikováno v: Biomedicines, Vol 9, Iss 7, p 749 (2021)

SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRP

Externí odkaz: https://doaj.org/article/b78a30cd91f84207aab5435c4944b4c9

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Akademický článek

Analyzing the Carotenoid Composition of Melilot (Melilotus officinalis (L.) Pall.) Extracts and the Effects of Isolated (All-E)-lutein-5,6-epoxide on Primary Sensory Neurons and Macrophages

Autor: Györgyi Horváth, Eszter Csikós, Eichertné Violetta Andres, Tímea Bencsik, Anikó Takátsy, Gergely Gulyás-Fekete, Erika Turcsi, József Deli, Éva Szőke, Ágnes Kemény, Maja Payrits, Lajos Szente, Marianna Kocsis, Péter Molnár, Zsuzsanna Helyes

Publikováno v: Molecules, Vol 26, Iss 2, p 503 (2021)

Melilotus officinalis is known to contain several types of secondary metabolites. In contrast, the carotenoid composition of this medicinal plant has not been investigated, although it may also contribute to the biological activities of the drug, suc

Externí odkaz: https://doaj.org/article/5be48b4ade6847e49725fa71abbb01f5

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Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Autor: Emőke Oláh, Valéria Tékus, Ádám Horváth, Éva Nagyné Scholz, Tamás Mészáros, Cecília P. Sár, Nikolett Szentes, Tamás Kálai, Zsuzsanna Helyes, Blanka Tóth, András Garami, Péter Mátyus, Miklós Poór, Krisztina Percze, Maja Payrits, Szilárd Pál, Éva Szőke, Eszter Fliszár-Nyúl

Publikováno v: Biomedicines
Volume 9
Issue 7
Biomedicines, Vol 9, Iss 749, p 749 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506872a8487a17207dfd6f50747d62c3

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Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice

Autor: Maja Payrits, Éva Borbély, Ágnes Hunyady, Erika Pintér, Gréta Mező

Publikováno v: GeroScience

Expression of the transient receptor potential ankyrin 1 (TRPA1) receptor has been demonstrated not only in the dorsal root and trigeminal ganglia but also in different brain regions (e.g., hippocampus, hypothalamus, and cortex). However, data concer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5389b3669590ed2198179bf46bd636e
https://doi.org/10.1007/s11357-019-00083-1

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Analyzing the Carotenoid Composition of Melilot (

Autor: Györgyi, Horváth, Eszter, Csikós, Eichertné Violetta, Andres, Tímea, Bencsik, Anikó, Takátsy, Gergely, Gulyás-Fekete, Erika, Turcsi, József, Deli, Éva, Szőke, Ágnes, Kemény, Maja, Payrits, Lajos, Szente, Marianna, Kocsis, Péter, Molnár, Zsuzsanna, Helyes

Publikováno v: Molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea60e916011fbdee0cd2dae5601de2e6
https://pubmed.ncbi.nlm.nih.gov/33477841

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Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification

Autor: Zsuzsanna Helyes, Éva Szőke, Miklos Kecskes, Tünde Biró-Sütő, Krisztina Pohóczky, János Erostyák, János Szolcsányi, Maja Payrits, Ádám Horváth, Géza Makkai, Éva Sághy, Angéla Kecskés

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5019, p 5019 (2020)
Volume 21
Issue 14

Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons and regulate nociceptor and inflammatory functions. Resolvins are endogenous lipid mediators. Resolvin D1 (RvD1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fadbb80472a83e62c4aac14c0f35f5f
http://europepmc.org/articles/PMC7404206

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