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The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands.

Autor: Tissino E; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. etissino@cro.it., Gaglio A; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Nicolò A; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany., Pozzo F; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Bittolo T; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Rossi FM; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Bomben R; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Nanni P; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Cattarossi I; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Zaina E; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Zimbo AM; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy., Ianna G; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Capasso G; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Forestieri G; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland., Moia R; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy., Datta M; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany., Härzschel A; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Olivieri J; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'Carlo Melzi' DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia, Udine, Italy., D'Arena G; Hematology, 'S. Luca' Hospital, ASL Salerno, Vallo della Lucania, Italy., Laurenti L; Fondazione Policlinico Universitario A Gemelli, IRCCS, Rome, Italy., Zaja F; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Chiarenza A; Division of Hematology, Ferrarotto Hospital, University of Catania, Catania, Italy., Palumbo GA; Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate 'G.F. Ingrassia', University of Catania, Catania, Italy., Martino EA; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy., Gentile M; Haematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy.; Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende, Italy., Rossi D; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland., Gaidano G; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy., Del Poeta G; Division of Hematology, University of Tor Vergata, Rome, Italy., Laureana R; Division of Hematology, University of Tor Vergata, Rome, Italy., Del Principe MI; Division of Hematology, University of Tor Vergata, Rome, Italy., Maity PC; Institut für Experimentelle Tumorforschung, Universitätsklinikum Ulm, Ulm, Germany., Jumaa H; Institut für Immunologie, Universitätsklinikum Ulm, Ulm, Germany., Hartmann TN; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Zucchetto A; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. zucchetto.soecs@cro.it., Gattei V; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. vgattei@cro.it.

Publikováno v: Leukemia [Leukemia] 2024 Oct; Vol. 38 (10), pp. 2127-2140. Date of Electronic Publication: 2024 Aug 14.

Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.

Autor: Härzschel A; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Li L; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Krenn PW; Max Planck Institute of Biochemistry, Martinsried, Germany.; Department of Biosciences, Cancer Cluster Salzburg, Paris-Lodron University of Salzburg, Salzburg, Austria., Szenes-Nagy E; Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Bayer E; Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Pfeifer D; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Polcik L; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Denk U; Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Höpner JP; Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Karabatak E; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Danner DJ; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Tangermann S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria., Kenner L; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria.; Department of Clinical Pathology, Medical University Vienna, Vienna, Austria.; Department of Experimental Pathology and Laboratory Animal Science, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria., Jumaa H; Institute of Immunology, Ulm University, Ulm, Germany., Greil R; Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Börries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Ruppert R; Max Planck Institute of Biochemistry, Martinsried, Germany., Maity PC; Institute of Immunology, Ulm University, Ulm, Germany., Hartmann TN; Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2022 Apr; Vol. 111 (4), pp. 745-758. Date of Electronic Publication: 2021 Dec 10.