Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Maitreya J Dunham"'
Autor:
Andreas Tsouris, Téo Fournier, Anne Friedrich, Jing Hou, Maitreya J Dunham, Joseph Schacherer
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1011119 (2024)
Assessing the complexity and expressivity of traits at the species level is an essential first step to better dissect the genotype-phenotype relationship. As trait complexity behaves dynamically, the classic dichotomy between monogenic and complex tr
Externí odkaz:
https://doaj.org/article/1552058c91234aa8a2f3ede0be85c7ae
Autor:
Rebecca Martin, Claudia Y Espinoza, Christopher R L Large, Joshua Rosswork, Cole Van Bruinisse, Aaron W Miller, Joseph C Sanchez, Madison Miller, Samantha Paskvan, Gina M Alvino, Maitreya J Dunham, M K Raghuraman, Bonita J Brewer
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1010850 (2024)
Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generati
Externí odkaz:
https://doaj.org/article/ca42be6fe50841a6a5966a175c1f7179
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1011091 (2024)
With the release of the telomere-to-telomere human genome sequence and the availability of both long-read sequencing and optical genome mapping techniques, the identification of copy number variants (CNVs) and other structural variants is providing n
Externí odkaz:
https://doaj.org/article/f4ac5e5b8cc9472c8d2bc8fb7d6b64fa
Publikováno v:
eLife, Vol 10 (2021)
Although studies of Saccharomyces cerevisiae have provided many insights into mutagenesis and DNA repair, most of this work has focused on a few laboratory strains. Much less is known about the phenotypic effects of natural variation within S. cerevi
Externí odkaz:
https://doaj.org/article/c7105fd1b6ec43f595ed2466e85f39a3
Autor:
Caiti S Smukowski Heil, Christopher R L Large, Kira Patterson, Angela Shang-Mei Hickey, Chiann-Ling C Yeh, Maitreya J Dunham
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008383 (2019)
Interspecific hybridization can introduce genetic variation that aids in adaptation to new or changing environments. Here, we investigate how hybrid adaptation to temperature and nutrient limitation may alter parental genome representation over time.
Externí odkaz:
https://doaj.org/article/40b3155209b94a90bf2e0c6048614265
Publikováno v:
eLife, Vol 8 (2019)
The genome forms specific three-dimensional contacts in response to cellular or environmental conditions. However, it remains largely unknown which proteins specify and mediate such contacts. Here we describe an assay, MAP-C (Mutation Analysis in Poo
Externí odkaz:
https://doaj.org/article/89494ddbe02046b99e31117069fc7334
Autor:
Justin C Fay, Ping Liu, Giang T Ong, Maitreya J Dunham, Gareth A Cromie, Eric W Jeffery, Catherine L Ludlow, Aimée M Dudley
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000147 (2019)
Strains of Saccharomyces cerevisiae used to make beer, bread, and wine are genetically and phenotypically distinct from wild populations associated with trees. The origins of these domesticated populations are not always clear; human-associated migra
Externí odkaz:
https://doaj.org/article/b6c4bad4d618493585da401d4f802499
Autor:
Seungsoo Kim, Ivan Liachko, Donna G Brickner, Kate Cook, William S Noble, Jason H Brickner, Jay Shendure, Maitreya J Dunham
Publikováno v:
eLife, Vol 6 (2017)
The budding yeast Saccharomyces cerevisiae is a long-standing model for the three-dimensional organization of eukaryotic genomes. However, even in this well-studied model, it is unclear how homolog pairing in diploids or environmental conditions infl
Externí odkaz:
https://doaj.org/article/318a83afa2e34630a4da3e7e904c1629
Autor:
Monica R Sanchez, Aaron W Miller, Ivan Liachko, Anna B Sunshine, Bryony Lynch, Mei Huang, Erica Alcantara, Christopher G DeSevo, Dave A Pai, Cheryl M Tucker, Margaret L Hoang, Maitreya J Dunham
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006585 (2017)
Evolutionary outcomes depend not only on the selective forces acting upon a species, but also on the genetic background. However, large timescales and uncertain historical selection pressures can make it difficult to discern such important background
Externí odkaz:
https://doaj.org/article/99b13bdbe9b3403c95f09013dfc3ba3d
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006339 (2016)
High-throughput sequencing has enabled genetic screens that can rapidly identify mutations that occur during experimental evolution. The presence of a mutation in an evolved lineage does not, however, constitute proof that the mutation is adaptive, g
Externí odkaz:
https://doaj.org/article/e2b0a83de3084ae9bd0933834c27638b