Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maithili C. Vantipalli"'
Autor:
Gordon J. Lithgow, Pedro Reis-Rodrigues, Uday S. Evani, Maithili C. Vantipalli, Bradford W. Gibson, Gregg Czerwieniec, Theodore W. Peters, Sean D. Mooney, Emily A. Gaman, Silvestre Alavez, Robert E. Hughes
Publikováno v:
Aging Cell
Summary While it is generally recognized that misfolding of specific proteins can cause late-onset disease, the contribution of protein aggregation to the normal aging process is less well understood. To address this issue, a mass spectrometry-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d51f210397f6430c71a17f0c660cfbb
https://doi.org/10.1111/j.1474-9726.2011.00765.x
https://doi.org/10.1111/j.1474-9726.2011.00765.x
Autor:
Mark Lucanic, Matthew S. Gill, Ida M. Klang, Jason M. Held, Gordon J. Lithgow, Jill Graham, Maithili C. Vantipalli, Bradford W. Gibson
Publikováno v:
Nature
Dietary restriction can extend lifespan in model organisms such as the nematode Caenorhabditis elegans. Although a number of key players in lifespan extension have been identified, little is known about the signals that coordinate the metabolic respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4092d3336b27106ed0ececc059815bb
https://doi.org/10.1038/nature10007
https://doi.org/10.1038/nature10007
Publikováno v:
Science. 312:1381-1385
Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a7f1ae75837a5934d6cec448468e19
https://doi.org/10.1126/science.1124981
https://doi.org/10.1126/science.1124981
Publikováno v:
Annals of the New York Academy of Sciences. 1067:120-128
During the last three decades the soil nematode C. elegans has become a prominent model organism for studying aging. Initially research in the C. elegans aging field was focused on the genetics of aging and single gene mutations that dramatically inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f2cb3e455384c48a0f9ac2b144d40f
https://doi.org/10.1196/annals.1354.015
https://doi.org/10.1196/annals.1354.015
Autor:
Silvestre Alavez, Gordon J. Lithgow, Maithili C. Vantipalli, David J. S. Zucker, Ida M. Klang
Publikováno v:
Nature. 472(7342)
The amyloid-binding histological dye thioflavin T (ThT) is known to slow protein aggregation in vitro. Experiments in Caenorhabditis elegans, commonly used as a model system for the study of ageing, now show that ThT also extends lifespan and slows a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04476936be0aedf4459710ba750a25de
https://pubmed.ncbi.nlm.nih.gov/21751864
https://pubmed.ncbi.nlm.nih.gov/21751864
Autor:
Matthew S. Gill, Anders Olsen, Maithili C. Vantipalli, Mark P. White, Michael G. Benedetti, James N. Sampayo, Gordon J. Lithgow, Amanda L. Foster
Publikováno v:
Experimental gerontology. 43(10)
The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and eco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6459d590f2fbf18daac85f03521e476b
https://pubmed.ncbi.nlm.nih.gov/18755260
https://pubmed.ncbi.nlm.nih.gov/18755260
Publikováno v:
Biogerontology. 7(4)
Mild hormetic heat treatments early in life can significantly increase the lifespan of the nematode C. elegans. We have examined the effects of heat treatments at different ages and show that treatments early in life cause the largest increases in li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d5a961fcfefa1a9de2306057495377
https://pubmed.ncbi.nlm.nih.gov/16826446
https://pubmed.ncbi.nlm.nih.gov/16826446
Publikováno v:
Toxicology. 226:16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db28680b433173a9ccbbf0153b83809
https://doi.org/10.1016/j.tox.2006.05.025
https://doi.org/10.1016/j.tox.2006.05.025