Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Maisem, Laabei"'
Autor:
Serena Bettoni, Mateusz Dziedzic, Damien Bierschenk, Maja Chrobak, Michal Magda, Maisem Laabei, Ben C. King, Kristian Riesbeck, Anna M. Blom
Publikováno v:
Journal of Innate Immunity, Pp 1-25 (2024)
Introduction. Streptococcus pyogenes (Group A Streptococcus; GAS) is a pathogen that causes over half a million deaths annually worldwide. Human immune cells respond to GAS infection by activating the NLRP3 inflammasome that leads to pro-inflammatory
Externí odkaz:
https://doaj.org/article/56a9b27650914a5b99065da0649db4dc
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/d12a9e9374fb4c3b9854366ac169e8b4
Publikováno v:
Microbial Biotechnology, Vol 16, Iss 7, Pp 1456-1474 (2023)
Abstract Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global health. Staphylococcus aureus remains a formidable human pathogen with high mortalit
Externí odkaz:
https://doaj.org/article/bd367d079a2a4da5aa3dd2ad3c002d4a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The primary host response to Staphylococcus aureus infection occurs via complement. Complement is an elegant evolutionarily conserved system, playing essential roles in early defences by working in concert with immune cells to survey, label
Externí odkaz:
https://doaj.org/article/147dfbdc85144386b29cb852f8741bd8
Autor:
Edward JA Douglas, Nathanael Palk, Tarcisio Brignoli, Dina Altwiley, Marcia Boura, Maisem Laabei, Mario Recker, Gordon YC Cheung, Ryan Liu, Roger C Hsieh, Michael Otto, Eoin O'Brien, Rachel M McLoughlin, Ruth C Massey
Publikováno v:
eLife, Vol 12 (2023)
The bloodstream represents a hostile environment that bacteria must overcome to cause bacteraemia. To understand how the major human pathogen Staphylococcus aureus manages this we have utilised a functional genomics approach to identify a number of n
Externí odkaz:
https://doaj.org/article/cdc03cf522bf4fe480f332e52fd5fd2c
Publikováno v:
Bio-Protocol, Vol 13, Iss 9 (2023)
During infection, complement plays a critical role in inflammation, opsonisation, and destruction of microorganisms. This presents a challenge for pathogens such as Staphylococcus aureus to overcome when invading the host. Our current knowledge on th
Externí odkaz:
https://doaj.org/article/e79179c2f39f4837b5eec2748356c91a
Publikováno v:
ChemistryOpen, Vol 11, Iss 10, Pp n/a-n/a (2022)
Abstract Antibiotic resistance is now a growing threat to human health, further exacerbated by the lack of new antibiotics. We describe the practical synthesis of a series of substituted polyamine succinamides and branched polyamines that are potenti
Externí odkaz:
https://doaj.org/article/c4d8728925a147cb893481be6869d32a
Autor:
Edward J. A. Douglas, Abdulaziz H. Alkhzem, Toska Wonfor, Shuxian Li, Timothy J. Woodman, Ian S. Blagbrough, Maisem Laabei
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
New therapeutic options are urgently required for the treatment of Staphylococcus aureus infections. Accordingly, we sought to exploit the vulnerability of S. aureus to naturally occurring polyamines. We have developed and tested the anti-staphylococ
Externí odkaz:
https://doaj.org/article/7c30206c98824363bb8158df33d48de4
Autor:
Scarlet Milo, Rachel A. Heylen, John Glancy, George T. Williams, Bethany L. Patenall, Hollie J. Hathaway, Naing T. Thet, Sarah L. Allinson, Maisem Laabei, A. Toby A. Jenkins
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Infection and blockage of indwelling urinary catheters is significant owing to its high incidence rate and severe medical consequences. Bacterial enzymes are employed as targets for small molecular intervention in human bacterial infections.
Externí odkaz:
https://doaj.org/article/d1510b5815fb4a74a8dabbd7ce110eb3
Autor:
Maisem Laabei, Seána Duggan
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT What do programmed cell death (PCD) and carbohydrate metabolism by-product transport have in common? Intriguingly, both processes involve the cidABC and lrgAB operons in the major human pathogen Staphylococcus aureus. Previously, CidA and Lr
Externí odkaz:
https://doaj.org/article/36216bb97a90491399d6be260f4d0e7c