Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial

Autor: Axel C.P. Diederichsen, Jes S. Lindholt, Sören Möller, Kristian A. Øvrehus, Søren Auscher, Jess Lambrechtsen, Susanne E. Hosbond, Dilek H. Alan, Grazina Urbonaviciene, Søren W. Becker, Maise H. Fredgart, Selma Hasific, Lars Folkestad, Oke Gerke, Lars Melholt Rasmussen, Jacob E. Møller, Hans Mickley, Jordi S. Dahl

Publikováno v: Diederichsen, A C P, Lindholt, J S, Möller, S, Øvrehus, K A, Auscher, S, Lambrechtsen, J, Hosbond, S E, Alan, D H, Urbonaviciene, G, Becker, S W, Fredgart, M H, Hasific, S, Folkestad, L, Gerke, O, Rasmussen, L M, Møller, J E, Mickley, H & Dahl, J S 2022, ' Vitamin K2 and D in Patients With Aortic Valve Calcification : A Randomized Double-Blinded Clinical Trial ', Circulation, vol. 145, no. 18, pp. 1387-1397 . https://doi.org/10.1161/CIRCULATIONAHA.121.057008

Background: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the inhibition of arterial calcification and has been suggested to reduce the progression rate of aortic valve calcification (AVC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b435dfa21dbe0a09ab7305805588eb
https://doi.org/10.1161/circulationaha.121.057008

Endothelin-1 shifts the mediator of bradykinin-induced relaxation from NO to H2O2in resistance arteries from patients with cardiovascular disease

Autor: Maria Bloksgaard, Jo G. R. De Mey, Luis A. Bagatolli, Maria Lyck Hansen, Maise H Fredgart, Lars Melholt Rasmussen, Kristoffer Rosenstand, Jonathan R. Brewer, Akhmadjon Irmukhamedov, Thomas Leurgans

Publikováno v: British Journal of Pharmacology. 173:1653-1664

Background and purpose We tested the hypothesis that in resistance arteries from cardiovascular disease (CVD) patients, effects of an endothelium-dependent vasodilator depend on the contractile stimulus. Experimental approach Arteries dissected from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::994004b7403ba2156495a92a33d1e136
https://doi.org/10.1111/bph.13467

P239Human resistance artery relaxing responses to an angiotensin AT2 receptor agonist depend on the type of contractile stimulus

Autor: Thomas Leurgans, J G R De Mey, Ulrike Muscha Steckelings, Maise H Fredgart, Lars Melholt Rasmussen, Akhmadjon Irmukhamedov

Publikováno v: Cardiovascular Research. 103:S42.5-S43

Aim: Test whether stimulation of angiotensin type 2 receptors (AT2R) reduces effects of various vasoconstrictor stimuli in resistance-sized arteries of cardiovascular disease patients. Methods: From biopsies of the parietal pericardium, obtained duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea62c6c4b0fd30aab777895807c437bd
https://doi.org/10.1093/cvr/cvu082.171