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Akademický článek

Implementation of Universal Pan-Cancer Germline Genetic Testing in an Arab Population: The Jordanian Exploratory Cancer Genetics Study

Autor: Hikmat Abdel-Razeq, Baha' Sharaf, Hira Bani Hani, Ramiz Abu Hijlih, Mais Alkyam, Khansa Al-Azzam, Shatha Elemian, Abdelghani Tbakhi, Areej Al-Atary, Rachel E. Ellsworth, Emily M. Russell, Edward D. Esplin, Malek Horani, Zeidan Zeidan, Abdulla Alzibdeh, Brandie Heald, Sarah M. Nielsen, Robert L. Nussbaum

Publikováno v: JCO Global Oncology, Vol , Iss 10 (2024)

PURPOSEGermline genetic testing (GGT) significantly affects cancer care. While universal testing has been studied in Western societies, less is known about adoption elsewhere.MATERIALS AND METHODSIn this study, 3,319 unselected, pan-cancer Jordanian

Externí odkaz: https://doaj.org/article/7d5166b37872449cb505823fc6b1095c

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Akademický článek

Pathogenic germline variants in patients with breast cancer: conversations across generations, practices and patients’ attitude

Autor: Hikmat Abdel-Razeq, Rawan Mustafa, Sarah Abdel-Razeq, Hala Abu-Fares, Sama Al Masri, Rana Damsees, Mariam El-Atrash, Shatha Elemian, Mais Alkyam, Khawlah Ammar, Rayan Bater, Marah Kderat, Abdulrahman Alhajahjeh

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Background: Breast cancer susceptibility genes such as BRCA1, BRCA2, PALB2, CHEK2 and many others are increasingly recognized among our patient population. In addition to their impact on treatment decisions of tested patients themselves, identifying

Externí odkaz: https://doaj.org/article/8969c859312547a493dd135867181475

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Akademický článek

Prevalence and clinical implications of germline mutations among Jordanian patients with ovarian cancer. The Jordanian exploratory cancer genetics (Jo‐ECAG) ovarian study

Autor: Hikmat Abdel‐Razeq, Khansa Al‐Azzam, Shatha Elemian, Hala Abu‐Fares, Areej Abu Sheikha, Hira Bani Hani, Rayan Bater, Baha’ Sharaf, Brandie Heald, Edward D. Esplin, Sarah M. Nielsen, Mais Alkyam, Lama Abujamous, Areej Al‐Attary

Publikováno v: Molecular Genetics & Genomic Medicine, Vol 11, Iss 4, Pp n/a-n/a (2023)

Abstract Background Ovarian cancer is one of the most common gynecological malignancies. Due to the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages. Patients with pathogenic and likely‐pathogenic germline

Externí odkaz: https://doaj.org/article/0dae60de389a4f7dbdd08820096a6984

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Guideline-Based, Multi-Gene Panel Germline Genetic Testing for at-Risk Patients with Breast Cancer

Autor: Hikmat Abdel-Razeq, Lama Abujamous, Khansa Al-Azzam, Hala Abu-Fares, Hira Bani Hani, Mais Alkyam, Baha' Sharaf, Shatha Elemian, Faris Tamimi, Fawzi Abuhijla, Sarah Edaily, Osama Salama, Hazem Abdulelah, Rand Daoud, Mohammad Abubaker, Areej Al-Atary

Publikováno v: Breast Cancer: Targets and Therapy. 15:1-10

Hikmat Abdel-Razeq,1,2 Lama Abujamous,3 Khansa Al-Azzam,1 Hala Abu-Fares,1 Hira Bani Hani,1 Mais Alkyam,1 Bahaâ Sharaf,1 Shatha Elemian,1 Faris Tamimi,1 Fawzi Abuhijla,4 Sarah Edaily,1 Osama Salama,1 Hazem Abdulelah,1 Rand Daoud,1 Mohammad Abuba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1198377dea4010f91f465ac29e717d10
https://doi.org/10.2147/bctt.s394092

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Prevalence and clinical implications of germline mutations among Jordanian patients with ovarian cancer. The Jordanian exploratory cancer genetics (Jo-ECAG) ovarian study

Publikováno v: Molecular geneticsgenomic medicineREFERENCES.

Ovarian cancer is one of the most common gynecological malignancies. Due to the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages. Patients with pathogenic and likely-pathogenic germline variants (PGVs) in BRC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b253af3bbb01ed7cf04d60312efa9bf
https://pubmed.ncbi.nlm.nih.gov/36537080

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Patterns and prevalence of pathogenic germline mutations using multi-gene panel testing in patients with ovarian cancer: The Jordanian Exploratory Cancer Genetics (Jo-ECAG) Ovarian Study

Autor: Khansa Al-Azzam, Hala Abu-Fares, Areej Abu Sheikha, Lama Abujamous, Mais Alkyam, Hira Bani Hani, Rayan Bater, Brandie Heald, Edward D. Esplin, Hikmat Abdel-Razeq

Publikováno v: Journal of Clinical Oncology. 40:e17593-e17593

e17593 Background: Ovarian cancer is one of the most common gynecological malignancies. Because of the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages contributing to high mortality rates. Patients with BRCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31baaeb66c3b5d5c533611bdaef8e32a
https://doi.org/10.1200/jco.2022.40.16_suppl.e17593

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