Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mairin Rafferty"'
Autor:
Hammad A. Qureshi, PhD, Runjan Chetty, MBBCh, FRCPC, FRCPA, FRCPath, DPhil (Oxon), Jogile Kuklyte, PhD, Karl Ratcliff, Maria Morrissey, PhD, Caitriona Lyons, PhD, Mairin Rafferty, PhD
Publikováno v:
Mayo Clinic Proceedings: Digital Health, Vol 1, Iss 4, Pp 601-613 (2023)
Recent introduction of digitalization in pathology has disrupted the field greatly with the potential to change the area immensely. Digital pathology has created the potential of applying advanced quantitative analysis and artificial intelligence (AI
Externí odkaz:
https://doaj.org/article/b1cfd53871774a9ab879840e90ede5fd
Autor:
Giuseppe Gullo, Alex J. Eustace, Alexandra Canonici, Denis M. Collins, Michael J. Kennedy, Liam Grogan, Oscar Breathhnach, John McCaffrey, Maccon Keane, Michael J. Martin, Rajnish Gupta, Gregory Leonard, Miriam O’Connor, Paula M. Calvert, Paul Donnellan, Janice Walshe, Enda McDermott, Kathleen Scott, Andres Hernando, Imelda Parker, David W. Murray, Alice C. O’Farrell, Ashwini Maratha, Patrick Dicker, Mairin Rafferty, Verena Murphy, Norma O’Donovan, William M. Gallagher, Bonnie Ky, Dimitrios Tryfonopoulos, Brian Moulton, Annette T. Byrne, John Crown
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Combining bevacizumab and chemotherapy produced superior response rates compared with chemotherapy alone in metastatic breast cancer. As bevacizumab may cause hypertension (HTN) and increase the risk of cardiac failure, we performed a pil
Externí odkaz:
https://doaj.org/article/dd373e9d21d44deea251f3cc0cedb80b
Autor:
Geert Berx, Jean-Christophe Marine, Joost J. van den Oord, Steven Goossens, Pieter Van Vlierberghe, Florian Rambow, Vanessa Andries, Jody J. Haigh, Danny Huylebroeck, Lieve Brochez, William M. Gallagher, Balazs Balint, Mairin Rafferty, Udupi Girish Mallya, Mitchell P. Levesque, Marieke I.G. Raaijmakers, Phil F. Cheng, Douglas S. Darling, Corinna Köhler, David Nittner, Jasper Wouters, Wouter Van Loocke, Nicolas Skrypek, Eva De Smedt, Jordy De Coninck, Joachim Taminau, Özden Akay, Gillian Blancke, Kenneth Bruneel, Geertrui Denecker, Niels Vandamme
Epithelial-to-mesenchymal transition (EMT)-inducing transcription factors (TF) are well known for their ability to induce mesenchymal states associated with increased migratory and invasive properties. Unexpectedly, nuclear expression of the EMT-TF Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0dbb78cec573eb5d9cfa72896700558
https://doi.org/10.1158/0008-5472.c.6511625.v1
https://doi.org/10.1158/0008-5472.c.6511625.v1
Autor:
Geert Berx, Jean-Christophe Marine, Joost J. van den Oord, Steven Goossens, Pieter Van Vlierberghe, Florian Rambow, Vanessa Andries, Jody J. Haigh, Danny Huylebroeck, Lieve Brochez, William M. Gallagher, Balazs Balint, Mairin Rafferty, Udupi Girish Mallya, Mitchell P. Levesque, Marieke I.G. Raaijmakers, Phil F. Cheng, Douglas S. Darling, Corinna Köhler, David Nittner, Jasper Wouters, Wouter Van Loocke, Nicolas Skrypek, Eva De Smedt, Jordy De Coninck, Joachim Taminau, Özden Akay, Gillian Blancke, Kenneth Bruneel, Geertrui Denecker, Niels Vandamme
Supplementary Figures. Supplementary Figure S1: Zeb2-wildtype cells outcompete Zeb2-negative cells in terms of expansion and differentiation. Supplementary Figure S2: Zeb2 does not accelerate melanoma development on a p53-wildtype background. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7334c2f0fa8adb45c9f55791cdcb1875
https://doi.org/10.1158/0008-5472.22423952
https://doi.org/10.1158/0008-5472.22423952
Autor:
William M. Gallagher, Nicolas Skrypek, Mairin Rafferty, Jean-Christophe Marine, Niels Vandamme, Joost van den Oord, Joachim Taminau, Marieke I.G. Raaijmakers, Corinna Köhler, Lieve Brochez, Gillian Blancke, Florian Rambow, Geertrui Denecker, Eva De Smedt, Pieter Van Vlierberghe, Vanessa Andries, David Nittner, Kenneth Bruneel, Douglas S. Darling, Jody J. Haigh, Steven Goossens, Jasper Wouters, Geert Berx, Wouter Van Loocke, Phil F. Cheng, Balázs Bálint, Özden Akay, Udupi Girish Mallya, Jordy De Coninck, Danny Huylebroeck, Mitchell P. Levesque
Publikováno v:
Cancer Research, 80(14), 2983-2995. American Association for Cancer Research Inc.
Epithelial-to-mesenchymal transition (EMT)-inducing transcription factors (TF) are well known for their ability to induce mesenchymal states associated with increased migratory and invasive properties. Unexpectedly, nuclear expression of the EMT-TF Z
Autor:
Markus Rehm, Mairin Rafferty, Peter Dynoodt, Elodie Hirschenhahn, Joost van den Oord, William M. Gallagher, Ciaran de Chaumont, Cristiano Guttà, Claudia Aura, Arman Rahman, Madhuri Warren, Jesuchristopher Joseph, Emilie M. Charles, Jasper Wouters
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 2, Pp 1-12 (2020)
Cell Death and Disease, Vol 11, Iss 2, Pp 1-12 (2020)
Despite the introduction of novel targeted therapies, chemotherapy still remains the primary treatment for metastatic melanoma in poorly funded healthcare environments or in case of disease relapse, with no reliable molecular markers for progression-
Autor:
John McCaffrey, Mairin Rafferty, Michael J. Kennedy, M. Keane, Miriam O'Connor, Ashwini Maratha, Enda W. McDermott, Paul Donnellan, Oscar Breathhnach, D. Tryfonopoulos, John Crown, Paula Calvert, Rajnish Gupta, Giuseppe Gullo, Verena Murphy, Denis M. Collins, G. Leonard, Annette T. Byrne, Imelda Parker, Kathleen Scott, David W. Murray, Bonnie Ky, Michael J. Martin, Patrick Dicker, Alexandra Canonici, Norma O'Donovan, Liam Grogan, Andres Hernando, Alex J Eustace, Brian Moulton, Alice C. O’Farrell, William M. Gallagher, Janice M. Walshe
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology
Background: Combining bevacizumab and chemotherapy produced superior response rates compared with chemotherapy alone in metastatic breast cancer. As bevacizumab may cause hypertension (HTN) and increase the risk of cardiac failure, we performed a pil
A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic
Autor:
Mairin Rafferty, Markus Rehm, Elaine W. Kay, Patrick G. Johnston, Mark Lawler, Manuela Salvucci, Pierre Laurent-Puig, Manuel Salto-Tellez, Alexa Resler, Sandra Van Schaeybroeck, William M. Gallagher, Arman Rahman, Jochen H. M. Prehn, Deborah A. McNamara, Richard H. Wilson, Daniel B. Longley, Girish Mallya Udupi
Publikováno v:
Salvucci, M, Rahman, A, Resler, A J, Udupi, G M, McNamara, D A, Kay, E W, Laurent-Puig, P, Longley, D B, Johnston, P G, Lawler, M, Wilson, R, Salto-Tellez, M, Van Schaeybroeck, S, Rafferty, M, Gallagher, W M, Rehm, M & Prehn, J H M 2019, ' A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic ', JCO Clinical Cancer Informatics . https://doi.org/10.1200/CCI.18.00056
PURPOSE Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the profiling of multiple model i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2486e53eefdde72b02d84179faff9aea
https://pure.qub.ac.uk/en/publications/a-machine-learning-platform-to-optimize-the-translation-of-personalized-network-models-to-the-clinic(a475aebb-4df2-4e02-8d86-47ca65e5b962).html
https://pure.qub.ac.uk/en/publications/a-machine-learning-platform-to-optimize-the-translation-of-personalized-network-models-to-the-clinic(a475aebb-4df2-4e02-8d86-47ca65e5b962).html
Autor:
Kieran Sheahan, Mairin Rafferty, Paul Donnellan, Elaine W. Kay, Owen MacEneaney, Derek G. Power, Julie Moran, Stephen P. Finn, Allan O'Keeffe, John Crown, Karin van den Hurk, Ian G. Murphy, Michelle Murphy, Balázs Bálint, Zsolt Orosz, Cynthia Heffron, Patrick O’Leary, William M. Gallagher, Joost van den Oord, Sinead Toomey, Clodagh M. McDermott, Cathal O'Brien, Louise Unwin, Padraic J. Regan, Ruben Yela, Dara M. FitzGerald, Robert Cummins, Enda W. McDermott, Bryan T. Hennessy
Publikováno v:
Melanoma Research, 25(3), 189-199. LIPPINCOTT WILLIAMS & WILKINS
Because of advances in targeted therapies, the clinical evaluation of cutaneous melanoma is increasingly based on a combination of traditional histopathology and molecular pathology. Therefore, it is necessary to expand our knowledge of the molecular
Autor:
Robert Cummins, Cecily Quinn, Etáin Daly, Aisling Pierce, Michael J. Duffy, Elaine W. Kay, Yue Fan, Mairin Rafferty, Dara M. FitzGerald, Miriam A Lynn, Fredrik Pontén, Louise Flanagan, Anthony O'Grady, Gillian O'Hurley, Karin Jirström, William M. Gallagher
Publikováno v:
Histopathology. 64:660-670
Aims Triple-negative breast cancer (TNBC) is responsible for a disproportionate number of breast cancer (BC) deaths, owing to its intrinsic aggressiveness and a lack of treatment options, especially targeted therapies. Thus, there is an urgent need f