Výsledky vyhledávání - "Mairi MacNeill"

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Autor: Arjan van der Vaart, Michael C. Heck, Carl E. Wagner, Pritika H. Shahani, Aleksandra Grozic, Nathan M. Robinson, Tamana Darwaiz, Mairi MacNeill, Micah Shimabuku, Ning Ma, Peter W. Jurutka, Joseph W. Ziller, David G. Deans, Samer H. Salama, Pamela A. Marshall

Publikováno v: Journal of Medicinal Chemistry. 59:8924-8940

Sulfonic acid analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene, 1) as well as seven novel and two reported analogues of 6-(ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)nicoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab0d3dba43dcb4696c24f88f6d71eac
https://doi.org/10.1021/acs.jmedchem.6b00812

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Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles

Autor: Ichiro Kaneko, Pedro I. Chavez, Jaskaran S. Bhogal, Pritika H. Shahani, Carl E. Wagner, Pamela A. Marshall, Arjan van der Vaart, Johnathon C. Swierski, Peter W. Jurutka, Mairi MacNeill, Ning Ma

Publikováno v: Pharmacology Research & Perspectives

In order to determine the feasibility of utilizing novel rexinoids for chemotherapeutics and as potential treatments for neurological conditions, we undertook an assessment of the side effect profile of select rexinoid X receptor (RXR) analogs that w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6522bcc2bf0e2d6d3f550a404606a0fd
https://pubmed.ncbi.nlm.nih.gov/26038698

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