Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Mairene Coto-Llerena"'
Autor:
Michele Garioni, Viviane J. Tschan, Lauriane Blukacz, Sandro Nuciforo, Romuald Parmentier, Luca Roma, Mairene Coto-Llerena, Heike Pueschel, Salvatore Piscuoglio, Tatjana Vlajnic, Frank Stenner, Hans-Helge Seifert, Cyrill A. Rentsch, Lukas Bubendorf, Clémentine Le Magnen
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Sarcomatoid Urothelial Bladder Cancer (SARC) is a rare and aggressive histological subtype of bladder cancer for which therapeutic options are limited and experimental models are lacking. Here, we report the establishment of a long-term 3D o
Externí odkaz:
https://doaj.org/article/bcfa1bd34b2c4ad09ce019db7e34e4ca
Autor:
Sumana Srivatsa, Hesam Montazeri, Gaia Bianco, Mairene Coto-Llerena, Mattia Marinucci, Charlotte K. Y. Ng, Salvatore Piscuoglio, Niko Beerenwinkel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Synthetic lethality can be used to identify potential drug targets in cancer based on simultaneous inactivation of two genes through genetic aberrations and gene silencing. Here, the authors develop a statistical framework to identify synthetic letha
Externí odkaz:
https://doaj.org/article/1e9e77d5338c4f05aac121e0023b2907
Autor:
Laia Simó-Riudalbas, Sandra Offner, Evarist Planet, Julien Duc, Laurence Abrami, Sagane Dind, Alexandre Coudray, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Claus Lindbjerg Andersen, Jesper Bertram Bramsen, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, the authors characterise cancer-specific transposable element-driven transpochimeric gene transcripts and highlight the role of POU5F1B in CRC grow
Externí odkaz:
https://doaj.org/article/a38569d1cb844be0bc2d549b4ade75f9
Autor:
Marie-Anne Meier, Sandro Nuciforo, Mairene Coto-Llerena, John Gallon, Matthias S. Matter, Caner Ercan, Jürg Vosbeck, Luigi M. Terracciano, Savas D. Soysal, Daniel Boll, Otto Kollmar, Raphaël Delaloye, Salvatore Piscuoglio, Markus H. Heim
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for e
Externí odkaz:
https://doaj.org/article/092df1cdee254031870f4d0caaa0bd75
Autor:
Charlotte K. Y. Ng, Eva Dazert, Tuyana Boldanova, Mairene Coto-Llerena, Sandro Nuciforo, Caner Ercan, Aleksei Suslov, Marie-Anne Meier, Thomas Bock, Alexander Schmidt, Sylvia Ketterer, Xueya Wang, Stefan Wieland, Matthias S. Matter, Marco Colombi, Salvatore Piscuoglio, Luigi M. Terracciano, Michael N. Hall, Markus H. Heim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated tumours and lacked information about the phosphoproteome. Here, the authors present a comprehensive HCC proteogenomics and phosphoproteomics study i
Externí odkaz:
https://doaj.org/article/0be87e27f0b443f98c2f8990e784ddcb
Autor:
Gaia Bianco, Mairene Coto-Llerena, John Gallon, Venkatesh Kancherla, Stephanie Taha-Mehlitz, Mattia Marinucci, Martina Konantz, Sumana Srivatsa, Hesam Montazeri, Federica Panebianco, Vijaya G. Tirunagaru, Marta De Menna, Viola Paradiso, Caner Ercan, Ahmed Dahmani, Elodie Montaudon, Niko Beerenwinkel, Marianna Kruithof-de Julio, Luigi M. Terracciano, Claudia Lengerke, Rinath M. Jeselsohn, Robert C. Doebele, François-Clément Bidard, Elisabetta Marangoni, Charlotte K. Y. Ng, Salvatore Piscuoglio
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
GATA3 mutations are common in ER-positive breast cancers yet are not targetable. This study describes pharmacological inhibition of MDM2 as a novel approach to target GATA3 deficiency, providing a molecularly guided treatment for this patient subclas
Externí odkaz:
https://doaj.org/article/9071cb3253ff484fad39debd9d0d2d7d
Autor:
John Gallon, Mairene Coto‐Llerena, Caner Ercan, Gaia Bianco, Viola Paradiso, Sandro Nuciforo, Stephanie Taha‐Melitz, Marie‐Anne Meier, Tujana Boldanova, Sofía Pérez‐del‐Pulgar, Sergio Rodríguez‐Tajes, Markus vonFlüe, Savas D. Soysal, Otto Kollmar, Josep M. Llovet, Augusto Villanueva, Luigi M. Terracciano, Markus H. Heim, Charlotte K. Y. Ng, Salvatore Piscuoglio
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 665-682 (2022)
Hepatocellular carcinomas (HCCs) usually arise from chronic liver disease (CLD). Precancerous cells in chronically inflamed environments may be ‘epigenetically primed’, sensitising them to oncogenic transformation. We investigated whether epigene
Externí odkaz:
https://doaj.org/article/01ede92b5b01440d89da11c31958e65e
Autor:
Caner Ercan, Mairene Coto-Llerena, John Gallon, Lana Fourie, Mattia Marinucci, Gabriel F. Hess, Jürg Vosbeck, Stephanie Taha-Mehlitz, Tuyana Boldanova, Marie-Anne Meier, Alexandar Tzankov, Matthias S. Matter, Martin H. K. Hoffmann, Luca Di Tommaso, Markus von Flüe, Charlotte K. Y. Ng, Markus H. Heim, Savas D. Soysal, Luigi M. Terracciano, Otto Kollmar, Salvatore Piscuoglio
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Plain language summary Focal nodular hyperplasia (FNH) is a lesion resulting from the abnormal growth of liver cells. It is typically considered a benign tumor that does not become malignant. In rare cases, FNH may occur alongside malignant hepatocel
Externí odkaz:
https://doaj.org/article/49161dc05fb841fc951e15d1ae5a8794
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis
Autor:
Ruize Gao, Ravi K R Kalathur, Mairene Coto‐Llerena, Caner Ercan, David Buechel, Song Shuang, Salvatore Piscuoglio, Michael T Dill, Fernando D Camargo, Gerhard Christofori, Fengyuan Tang
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-20 (2021)
Abstract Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In this study, a combination of shRNA‐mediated synthetic lethality screening and transcriptomic ana
Externí odkaz:
https://doaj.org/article/0a45c210533448afa645988d3bfff73d
Autor:
Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+
Externí odkaz:
https://doaj.org/article/490276d24a40458c86a47d3c716fb078