mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions

Autor: Emma Cosialls, Emeline Pacreau, Clémence Duruel, Sara Ceccacci, Rima Elhage, Christophe Desterke, Kevin Roger, Chiara Guerrera, Romane Ducloux, Sylvie Souquere, Gérard Pierron, Ivan Nemazanyy, Mairead Kelly, Elise Dalmas, Yunhua Chang, Vincent Goffin, Maryam Mehrpour, Ahmed Hamaï

Publikováno v: Cell Death and Disease, Vol 14, Iss 11, Pp 1-14 (2023)

Abstract Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin

Externí odkaz: https://doaj.org/article/5ad5e737bb114cf494300de72b4fe890

Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

Autor: Miroslaw Zajac, Agathe Lepissier, Elise Dréano, Benoit Chevalier, Aurélie Hatton, Mairead Kelly-Aubert, Daniela Guidone, Gabrielle Planelles, Aleksander Edelman, Emmanuelle Girodon, Alexandre Hinzpeter, Gilles Crambert, Iwona Pranke, Luis. J. V. Galietta, Isabelle Sermet-Gaudelus

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate (HCO3−) transport into the Airway Surface Liquid (ASL). We investigated th

Externí odkaz: https://doaj.org/article/216815fa6c914e6888231ca2f55b094c

Management of oral and maxillofacial trauma during the first wave of the COVID-19 pandemic in the United Kingdom

Autor: F.A. Puglia, A. Hills, B. Dawoud, P. Magennis, G.A. Chiu, Aidan Adams, Ayesha Ahmed, Huma Aiman, Aya Al-Harbawee, Lucy Alderson, Jack Allison, Mariam Asaad, Katriana Bacik, Indran Balasundaram, Lydia Barker-Chapman, Sherif Bayoumi, Robert Bentley, Vyomesh Bhatt, Manuel Blanco-Guzman, Angela Boscarino, Raghu Boyapati, Deborah Boyd, Theo Boye, Dirk Stephanus Brandsma, Laura Brooks, Timothy Brown, Marta Cabral, Micheala Camilleri, Kris Carroll, Laura Chapman, Geoff Chiu, Gulshana Choudhury, Anna Chrystal, Tom Cole, Zachary Cole-Healy, Benjamin Collard, Sarah Crummey, Roger Currie, Huw T. Davies, Rumandeep Dhillon, David Drake, Rebecca Exley, Kathleen Fan, Shona Feare, David Fisher, Cristina Frezzini, Lynne Fryer, Andrew Fulton, Andrew Gardner, Shona Garland, Peter Glen, David Graham, Catherine Grant, Elizabeth Gruber, Ben Gurney, Nick Hampton, Abeer Hasan, Kerry Herd, Stuart Hislop, Michael Ho, David Houghton, Ceri Hughes, Hannah Huguet, Huw Jones, Shyam Karia, Felix W. Karst, Karim Kassam, Mairead Kelly, Steven Key, Rhydian King, Saranya Konathala, Raghav Kulkarni, Anand Kumar, Deepshikha Kumar, Paul Lang, Kirstie Lau, David Laugharne, Nicholas J. Lee, Leh Lim, Jasmine Loke, Terrence Lowe, Patrick Magennis, Vasanthan Manoharan, Louisa McCaffrey, Nicola McCurley, Christopher McDonald, Edward McParland, Hussein Mohammedbhai, Colm Murphy, Dara Murphy, Ayesha Mustafa, Prady Naredla, Kowoon Noh, Kerry O'Brien, Kevin O'Grady, Lewis Olsson, Joan Onochie, Anika Patel, Ankit Patel, Jayna Patel, Sachit Patel, Rajat Paul, Samantha Plant, Eoin Power, Dhulshan Preena, Euan Rae, Eson Rasikh, Neelam Rathod, Dhurrika Raveendran, Zahrah Raza, Charlotte Richards, Hamed Safaei, Sunil Sah, Kiren Sall, Susan Sanders, Rupert Scott, Keval Shah, Kishore Shekar, Faheema Sidat, Branan Sivanantha, Claire Skimming, James Sloane, Caroline Smith, Avraj Sohanpal, Janki Solanki, Kohmal Solanki, Andrew Stirrup, Imran Suida, Jill Sweeney, Eleanor Swinnerton, Eilidh Thomas, Sundeep Thusu, Hannah Tompkins, Clare Tyers, Drazsen Vuity, Tom Walker, Callum Wemyss, Fiona Wright, Elizabeth Yeung, Lindsey Young

Publikováno v: The British Journal of Oral & Maxillofacial Surgery

Background We assess the effect of Coronavirus disease 2019 (COVID-19) on UK oral and maxillofacial (OMF) trauma services and patient treatment during the first wave of the pandemic. Materials and Methods From April 1st 2020 until July 31st 2020, OMF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbc0e81dc005facab89fbc93ba1f600
https://doi.org/10.1016/j.bjoms.2020.12.021

Virtual voice clinics in the COVID-19 era: have they been helpful?

Autor: Carolina Tania Maria Watters, Benjamin Miller, Mairead Kelly, Yakubu Karagama, Victoria Burnay, Elfy B Chevretton

Publikováno v: European Archives of Oto-Rhino-Laryngology

Purpose In response to the coronavirus pandemic, a tertiary combined Laryngology-Speech Therapy voice clinic was converted to a wholly virtual clinic, with consultations carried out via telephone or video. The aim of our mixed method study was to ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e51a78dd9ea984ae72d6ae96f6dc95d
https://doi.org/10.1007/s00405-021-06643-6

Coblation debulking of a paediatric laryngeal plexiform neurofibroma: a pragmatic response to a rare tumour

Autor: James Schuster-Bruce, Mairead Kelly, Ana Bernic, Sabrina Brar, Joy Barber, Prince Modayil

Publikováno v: Journal of Surgical Case Reports

Laryngeal neurofibroma is a rare but important differential diagnosis in a patient presenting with stridor. In paediatric patients, these lesions present a management conundrum: complete surgical resection is the established treatment of choice, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffba1019f83220b83dd33de972415bfb
http://europepmc.org/articles/PMC8791663