Novel imaging tools to study mitochondrial morphology in Caenorhabditis elegans .

Autor: Valera-Alberni M; Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA., Yao P; Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA., Romero-Sanz S; Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA., Lanjuin A; Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA., Mair WB; Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA wmair@hsph.harvard.edu.

Publikováno v: Life science alliance [Life Sci Alliance] 2024 Sep 11; Vol. 7 (11). Date of Electronic Publication: 2024 Sep 11 (Print Publication: 2024).

An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress.

Autor: Vergani-Junior CA; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Moro RP; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Pinto S; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., De-Souza EA; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Camara H; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Section on Integrative Physiology & Metabolism, Joslin Diabetes Center, Boston, MA, USA., Braga DL; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Tonon-da-Silva G; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Knittel TL; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Ruiz GP; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Ludwig RG; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Massirer KB; Center for Molecular Biology and Genetic Engineering (CBMEG), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Center of Medicinal Chemistry (CQMED), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Mair WB; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. morima@unicamp.br.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. morima@unicamp.br.; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. morima@unicamp.br.; Experimental Medicine Research Cluster (EMRC), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. morima@unicamp.br.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 09; Vol. 15 (1), pp. 3070. Date of Electronic Publication: 2024 Apr 09.

The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.

Autor: Silva-García CG; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Center on the Biology of Aging, Brown University, Providence, RI, USA.; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA., Láscarez-Lagunas LI; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Papsdorf K; Department of Genetics, Stanford University, Stanford, CA, USA., Heintz C; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Prabhakar A; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Morrow CS; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Pajuelo Torres L; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Sharma A; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Liu J; Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Colaiácovo MP; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Brunet A; Department of Genetics, Stanford University, Stanford, CA, USA.; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA., Mair WB; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. wmair@hsph.harvard.edu.

Publikováno v: Nature aging [Nat Aging] 2023 Nov; Vol. 3 (11), pp. 1358-1371. Date of Electronic Publication: 2023 Nov 09.

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans.

Autor: Smith HJ; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Lanjuin A; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Sharma A; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Prabhakar A; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Nowak E; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Stine PG; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Sehgal R; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America., Stojanovski K; Institute for Cell Biology, University of Bern, Bern, Switzerland., Towbin BD; Institute for Cell Biology, University of Bern, Bern, Switzerland., Mair WB; Dept. Molecular Metabolism, Harvard TH Chan School of Public Health, Massachusetts, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2023 Sep 18; Vol. 19 (9), pp. e1010938. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023).

Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.

Autor: Papsdorf K; Department of Genetics, Stanford University, Stanford, CA, USA., Miklas JW; Department of Genetics, Stanford University, Stanford, CA, USA., Hosseini A; Department of Genetics, Stanford University, Stanford, CA, USA., Cabruja M; Department of Genetics, Stanford University, Stanford, CA, USA., Morrow CS; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Savini M; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Yu Y; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Silva-García CG; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Haseley NR; Department of Genetics, Stanford University, Stanford, CA, USA., Murphy LM; Department of Genetics, Stanford University, Stanford, CA, USA., Yao P; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., de Launoit E; Department of Genetics, Stanford University, Stanford, CA, USA., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Snyder MP; Department of Genetics, Stanford University, Stanford, CA, USA., Wang MC; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Mair WB; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Brunet A; Department of Genetics, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.; Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.; Wu Tsai Institute of Neurosciences, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2023 May; Vol. 25 (5), pp. 672-684. Date of Electronic Publication: 2023 May 01.