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Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

Autor: Maini Rekdal, Vayu, Bess, Elizabeth N, Bisanz, Jordan E, Turnbaugh, Peter J, Balskus, Emily P

Publikováno v: Science (New York, N.Y.), vol 364, iss 6445

The human gut microbiota metabolizes the Parkinson's disease medication Levodopa (l-dopa), potentially reducing drug availability and causing side effects. However, the organisms, genes, and enzymes responsible for this activity in patients and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::215c1008e38e10c75753f965c71673dd
https://escholarship.org/uc/item/9tp716qp

Neurospora intermedia from a traditional fermented food enables waste-to-food conversion.

Autor: Maini Rekdal V; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.; Miller Institute for Basic Research in Science, University of California Berkeley, Berkeley, CA, USA.; Joint BioEnergy Institute, Emeryville, CA, USA., Villalobos-Escobedo JM; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Tecnológico de Monterrey, Institute for Obesity Research, Monterrey, Nuevo León, Mexico., Rodriguez-Valeron N; ALCHEMIST Explore, Research and Development, Alchemist Aps, Copenhagen, Denmark.; Basque Culinary Center, Mondragon Universitatea, Donostia, Gipuzkoa, Spain., Olaizola Garcia M; ALCHEMIST Explore, Research and Development, Alchemist Aps, Copenhagen, Denmark., Prado Vásquez D; ALCHEMIST Explore, Research and Development, Alchemist Aps, Copenhagen, Denmark., Rosales A; Joint BioEnergy Institute, Emeryville, CA, USA.; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA., Sörensen PM; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Baidoo EEK; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Calheiros de Carvalho A; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Riley R; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Lipzen A; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., He G; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Yan M; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Haridas S; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Daum C; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Yoshinaga Y; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Ng V; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Grigoriev IV; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Munk R; ALCHEMIST Explore, Research and Development, Alchemist Aps, Copenhagen, Denmark., Wijaya CH; Department of Food Science and Technology, Faculty of Agricultural Engineering, IPB University (Bogor Agricultural University), Dramaga, Indonesia., Nuraida L; Department of Food Science and Technology, Faculty of Agricultural Engineering, IPB University (Bogor Agricultural University), Dramaga, Indonesia., Damayanti I; Department of Food Science and Technology, Faculty of Agricultural Engineering, IPB University (Bogor Agricultural University), Dramaga, Indonesia., Cruz-Morales P; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Keasling JD; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA. keasling@berkeley.edu.; Joint BioEnergy Institute, Emeryville, CA, USA. keasling@berkeley.edu.; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA. keasling@berkeley.edu.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. keasling@berkeley.edu.; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark. keasling@berkeley.edu.; California Institute of Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, CA, USA. keasling@berkeley.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Oct; Vol. 9 (10), pp. 2666-2683. Date of Electronic Publication: 2024 Aug 29.

Cooking shapes the structure and function of the gut microbiome.

Autor: Carmody RN; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA. carmody@fas.harvard.edu.; Center for Systems Biology, Harvard University, Cambridge, MA, USA. carmody@fas.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. carmody@fas.harvard.edu., Bisanz JE; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Bowen BP; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Maurice CF; Center for Systems Biology, Harvard University, Cambridge, MA, USA.; Department of Microbiology & Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec, Canada., Lyalina S; Gladstone Institutes, University of California San Francisco, San Francisco, CA, USA., Louie KB; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Treen D; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Chadaideh KS; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA., Maini Rekdal V; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Bess EN; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Spanogiannopoulos P; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Ang QY; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Bauer KC; Center for Systems Biology, Harvard University, Cambridge, MA, USA., Balon TW; Department of Medicine, Metabolic Phenotyping Core and In Vivo Imaging System Core, Boston University, Boston, MA, USA., Pollard KS; Gladstone Institutes, University of California San Francisco, San Francisco, CA, USA., Northen TR; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; DOE Joint Genome Institute, Walnut Creek, CA, USA., Turnbaugh PJ; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA. peter.turnbaugh@ucsf.edu.; Center for Systems Biology, Harvard University, Cambridge, MA, USA. peter.turnbaugh@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. peter.turnbaugh@ucsf.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2052-2063. Date of Electronic Publication: 2019 Sep 30.