Zobrazeno 1 - 10
of 3 462
pro vyhledávání: '"Main protease"'
Autor:
Mohamed Ibrahim, Xinyuanyuan Sun, Vinicius Martins de Oliveira, Ruibin Liu, Joseph Clayton, Haifa El Kilani, Jana Shen, Rolf Hilgenfeld
Publikováno v:
hLife, Vol 2, Iss 8, Pp 419-433 (2024)
During the continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the Omicron variant of concern emerged in the second half of 2021 and has been dominant since November of that year. Along with its sublineages, it has m
Externí odkaz:
https://doaj.org/article/267a1214c0c245738d97eb6061005e8c
Publikováno v:
Jurnal Kimia Sains dan Aplikasi, Vol 27, Iss 7, Pp 336-345 (2024)
In December 2019, the first COVID-19 cases were in Wuhan, China. This case is a global concern and a threat to public health. Based on previous research using molecular docking methods, it was found that flavonoids exhibit strong inhibitory activity
Externí odkaz:
https://doaj.org/article/2a17cb38ae8d4534bb4cec42e56f7776
Autor:
Khulood H. Oudah, Mazin A. A. Najm, Reham F. Barghash, Omnia Kutkat, Mohamed GabAllah, Amgad Albohy, Khaled A. M. Abouzid
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract The search for new molecules targeting SARS-CoV-2 has been a priority since 2020. The continuous evolution of new mutants increases the need for more research in the area. One way to find new leads is to repurpose existing drugs and molecule
Externí odkaz:
https://doaj.org/article/1103d9c12dac43f5868d490f99f303ba
Publikováno v:
COVID, Vol 4, Iss 6, Pp 672-695 (2024)
One of the most pressing challenges associated with SARS treatment is the emergence of new variants that may be transmissible, causing more severe disease or being resistant to the current standard of treatment. This study aimed to identify potential
Externí odkaz:
https://doaj.org/article/3af64b6060f6470fb94f9b633d30be08
Autor:
Rabea Voget, Julian Breidenbach, Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach, Lan Phuong Vu, Renato H. Weiße, Ulrike Bartz, Norbert Sträter, Christa E. Müller, Michael Gütschow
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2349-2357 (2024)
A titrant for the SARS-CoV-2 main protease (Mpro) was developed that enables, for the first time, the exact determination of the concentration of the enzymatically active Mpro by active-site titration. The covalent binding mode of the tetrapeptidic t
Externí odkaz:
https://doaj.org/article/58da7d67bdec41a39ad53783d3a36b34
Autor:
Kannan Raman, Rajagopal Kalirajan, Fahadul Islam, Srikanth Jupudi, Divakar Selvaraj, Gomathi Swaminathan, Laliteshwar Pratap Singh, Ritesh Rana, Shopnil Akash, Md. Rezaul Islam, Firzan Nainu, Talha Bin Emran, Turki M. Dawoud, Mohammed Bourhia, Musaab Dauelbait, Rashu Barua
Publikováno v:
ChemistryOpen, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract In the present work, phytoconstituents from Citrus limon are computationally tested against SARS‐CoV‐2 target protein such as Mpro ‐ (5R82.pdb), Spike ‐ (6YZ5.pdb) &RdRp ‐ (7BTF.pdb) for COVID‐19. Docking was done by glide model,
Externí odkaz:
https://doaj.org/article/5ba4d384037e4eeab8b401e4ea8377ab
Autor:
Fee Faysal Ahmed, Md. Mafizur Rahman, Md. Azizul Islam, Md. Abdullah Al Mashud, Rizone Al Hasib, Mohammad Abu Hena Mostofa Jamal, Md. Shahedur Rahman, Md. Chayan Ali
Publikováno v:
F1000Research, Vol 10 (2024)
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fomented a climate of fear worldwide due to its rapidly spreading nature, and high mortality rate. The World Health Organization (WHO) declared it as a global pandemic on 11
Externí odkaz:
https://doaj.org/article/8f9f222ba6614261869b62b0d36d1e20
Autor:
Farah Nazir, Arnaud John Kombe Kombe, Zunera Khalid, Shaheen Bibi, Hongliang Zhang, Songquan Wu, Tengchuan Jin
Publikováno v:
Molecular and Cellular Probes, Vol 77, Iss , Pp 101973- (2024)
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of people and continues to wreak havoc across the globe. This sudden and deadly pandemic emphasizes the necessity f
Externí odkaz:
https://doaj.org/article/853e435a0410496ebefc86742439f373
Autor:
Renee Delgado, Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Ashley Cuell, Megan Tansiongco, Christina B. Cooley, Yanjun Chen, Agnieszka Dabrowska, Rahul Basu, Paulina Duhita Anindita, Dahai Luo, Peter I. Dosa, Daniel A. Harki, Thomas Bannister, Louis Scampavia, Timothy P. Spicer, Reuben S. Harris
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100181- (2024)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2, SARS2) is responsible for the COVID-19 pandemic and infections that continue to affect the lives of millions of people worldwide, especially those who are older and/or immunocompromised. Th
Externí odkaz:
https://doaj.org/article/c4f7ebe12cd3480bb2ae4720b580813c
Autor:
Peter Kovar, Paul L Richardson, Alla Korepanova, Gustavo A Afanador, Vladimir Stojkovic, Tao Li, Michael R Schrimpf, Teresa I Ng, David A Degoey, Sujatha M Gopalakrishnan, Jun Chen
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100179- (2024)
The SARS-CoV-2 main protease (Mpro) is essential for viral replication because it is responsible for the processing of most of the non-structural proteins encoded by the virus. Inhibition of Mpro prevents viral replication and therefore constitutes a
Externí odkaz:
https://doaj.org/article/0e0b9455143c4b4e883db21e8a29ec2c