SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.

Autor: Lai X; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Lui SKL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Lam HY; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Adachi Y; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan., Sim WJ; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore., Vasilevski N; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Armstrong NJ; School of Electrical Engineering, Computing and Mathematical Sciences, Faculty of Science and Engineering, Curtin University, Bentley, WA, 6102, Australia., Bridgeman SC; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Main NM; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tirnitz-Parker JEE; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Thiery JP; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. tjp@visitor.nus.edu.sg.; Guangzhou Laboratory, Guangzhou International Bio Island, Haizhu District, Guangzhou, Guangdong, 510530, China. tjp@visitor.nus.edu.sg., Ebi H; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan. hebi@aichi-cc.jp.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan. hebi@aichi-cc.jp., Kumar AP; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore. apkumar@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. apkumar@nus.edu.sg., Eichhorn PJA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. Pieter.eichhorn@curtin.edu.au.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. Pieter.eichhorn@curtin.edu.au.; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2023 Dec 15; Vol. 7 (1), pp. 136. Date of Electronic Publication: 2023 Dec 15.

CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury.

Autor: Yee C; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia.; Gastroenterology and Liver Laboratory, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia., Main NM; Gastroenterology and Liver Laboratory, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia., Terry A; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia.; Gastroenterology and Liver Laboratory, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia., Stevanovski I; Gastroenterology and Liver Laboratory, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia., Maczurek A; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia., Morgan AJ; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia., Calabro S; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia., Potter AJ; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia., Iemma TL; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia., Bowen DG; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia.; A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia., Ahlenstiel G; Western Sydney School of Medicine, Blacktown Hospital, Blacktown, NSW, Australia., Warner FJ; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia., McCaughan GW; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia.; A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia., McLennan SV; Department of Endocrinology, Department of Medicine and Bosch Institute, Royal Prince Alfred Hospital, The University of Sydney, NSW, Australia., Shackel NA; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, NSW, Australia.; Gastroenterology and Liver Laboratory, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia.; A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.; Liverpool Hospital, Liverpool, NSW, Australia.

Publikováno v: PloS one [PLoS One] 2019 Jul 10; Vol. 14 (7), pp. e0215557. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).