Ablating the glutaredoxin-2 (Glrx2) gene protects male mice against non-alcoholic fatty liver disease (NAFLD) by limiting oxidative distress.

Autor: Grayson C; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada., Chalifoux O; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada., Russo MST; Goodman Cancer Institute, McGill University, Qc, H3A 1A3, Montréal, Québec, Canada; Department of Medicine, McGill University, Qc, H3A 1A3, Montréal, Québec, Canada., Avizonis DZ; Goodman Cancer Institute, McGill University, Qc, H3A 1A3, Montréal, Québec, Canada; Department of Medicine, McGill University, Qc, H3A 1A3, Montréal, Québec, Canada., Sterman S; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada., Faerman B; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada., Koufos O; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada., Agellon LB; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada., Mailloux RJ; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Ste Anne de Bellevue, Québec, Canada. Electronic address: ryan.mailloux@mcgill.ca.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2024 Nov 01; Vol. 224, pp. 660-677. Date of Electronic Publication: 2024 Sep 14.

Fundamentals of redox regulation in biology.

Autor: Sies H; Institute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. sies@hhu.de.; Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. sies@hhu.de., Mailloux RJ; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada. ryan.mailloux@mcgill.ca., Jakob U; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. ujakob@umich.edu.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA. ujakob@umich.edu.

Publikováno v: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2024 Sep; Vol. 25 (9), pp. 701-719. Date of Electronic Publication: 2024 Apr 30.

Fatty acid oxidation drives mitochondrial hydrogen peroxide production by α-ketoglutarate dehydrogenase.

Autor: Grayson C; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada., Faerman B; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada., Koufos O; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada., Mailloux RJ; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada. Electronic address: ryan.mailloux@mcgill.ca.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Apr; Vol. 300 (4), pp. 107159. Date of Electronic Publication: 2024 Mar 11.

Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress.

Autor: Chalifoux O; Faculty of Agricultural and Environmental Sciences, The School of Human Nutrition, McGill University, Ste.-Anne-de-Bellevue, Quebec, Canada., Faerman B; Faculty of Agricultural and Environmental Sciences, The School of Human Nutrition, McGill University, Ste.-Anne-de-Bellevue, Quebec, Canada., Mailloux RJ; Faculty of Agricultural and Environmental Sciences, The School of Human Nutrition, McGill University, Ste.-Anne-de-Bellevue, Quebec, Canada. Electronic address: ryan.mailloux@mcgill.ca.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105399. Date of Electronic Publication: 2023 Oct 28.

Mitochondrial function and phenotype are defined by bioenergetics.

Autor: Mailloux RJ; The School of Human Nutrition, McGill University, Ste.-Anne-de-Bellevue, Quebec, Canada. ryan.mailloux@mcgill.ca., Treberg J; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Grayson C; The School of Human Nutrition, McGill University, Ste.-Anne-de-Bellevue, Quebec, Canada., Agellon LB; The School of Human Nutrition, McGill University, Ste.-Anne-de-Bellevue, Quebec, Canada., Sies H; Institute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Publikováno v: Nature metabolism [Nat Metab] 2023 Oct; Vol. 5 (10), pp. 1641.