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Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

Autor: Marchal-Duval, Emmeline, Homps-Legrand, Méline, Froidure, Antoine, Jaillet, Madeleine, Ghanem, Mada, Lou, Deneuville, Justet, Aurélien, Maurac, Arnaud, Vadel, Aurelie, Fortas, Emilie, Cazes, Aurelie, Joannes, Audrey, Giersh, Laura, Mal, Herve, Mordant, Pierre, Piolot, Tristan, Truchin, Marin, Mounier, Carine, Schirduan, Ksenija, Korfei, Martina, Gunther, Andreas, Mari, Bernard, Jaschinski, Frank, Crestani, Bruno, Mailleux, Arnaud

Publikováno v: eLife, Vol. 12, no.1, p. 1-32 (2023)
eLife
eLife, 2023, 12, pp.e79840. ⟨10.7554/eLife.79840⟩

Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcription facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1996ed1dcf65d6fdb8ee48a755b89e39
https://hdl.handle.net/2078.1/276007

Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia

Autor: Ghanem, Mada, Homps-Legrand, Méline, Garnier, Marc, Morer, Lise, Goletto, Tiphaine, Frija-Masson, Justine, Wicky, Paul-Henri, Jaquet, Pierre, Bancal, Catherine, Hurtado-Nedelec, Margarita, de Chaisemartin, Luc, Jaillet, Madeleine, Mailleux, Arnaud, Quesnel, Christophe, Poté, Nicolas, Debray, Marie-Pierre, de Montmollin, Etienne, Neukirch, Catherine, Borie, Raphael, Taillé, Camille, Crestani, Bruno, Covid Cohort Study Group, French, Andréjak, Claire

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2021, 321 (5), pp.L847-L858. ⟨10.1152/ajplung.00105.2021⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321 (5), pp.L847-L858. ⟨10.1152/ajplung.00105.2021⟩

Increased blood fibrocytes are associated with a poor prognosis in fibrotic lung diseases. We aimed to determine whether the percentage of circulating fibrocytes could be predictive of severity and prognosis during coronavirus disease 2019 (COVID-19)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e586edbd6c6f4e789a76f2dcdb204760
https://doi.org/10.1152/ajplung.00105.2021