Gauging Dynamics-driven Allostery Using a New Computational Tool: A CAP Case Study.

Autor: Kornev AP; Departmen of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: akornev@ucsd.edu., Weng JH; Departmen of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA., Maillard RA; Department of Chemistry, Georgetown University, Washington, DC 20007, USA., Taylor SS; Departmen of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.

Publikováno v: Journal of molecular biology [J Mol Biol] 2024 Jan 15; Vol. 436 (2), pp. 168395. Date of Electronic Publication: 2023 Dec 13.

The cofactor-dependent folding mechanism of Drosophila cryptochrome revealed by single-molecule pulling experiments.

Autor: Foroutannejad S; Department of Chemistry, Georgetown University, Washington, DC, USA., Good LL; Department of Chemistry, Georgetown University, Washington, DC, USA., Lin C; Department of Chemistry & Chemical Biology, Cornell University, Ithaca, NY, USA., Carter ZI; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA., Tadesse MG; Department of Mathematics and Statistics, Georgetown University, Washington, DC, USA., Lucius AL; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA., Crane BR; Department of Chemistry & Chemical Biology, Cornell University, Ithaca, NY, USA., Maillard RA; Department of Chemistry, Georgetown University, Washington, DC, USA. rodrigo.maillard@georgetown.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 24; Vol. 14 (1), pp. 1057. Date of Electronic Publication: 2023 Feb 24.

cAMP is an allosteric modulator of DNA-binding specificity in the cAMP receptor protein from Mycobacterium tuberculosis.

Autor: Gárate F; Department of Chemistry, Georgetown University, Washington, District of Columbia, USA., Dokas S; Department of Chemistry, Georgetown University, Washington, District of Columbia, USA., Lanfranco MF; Department of Chemistry, Georgetown University, Washington, District of Columbia, USA., Canavan C; Department of Chemistry, Georgetown University, Washington, District of Columbia, USA., Wang I; Department of Chemistry, Georgetown University, Washington, District of Columbia, USA., Correia JJ; Department of Cell and Molecular Biology, The University of Mississippi Medical Center, Jackson, Mississippi, USA., Maillard RA; Department of Chemistry, Georgetown University, Washington, District of Columbia, USA. Electronic address: rodrigo.maillard@georgetown.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100480. Date of Electronic Publication: 2021 Feb 26.

Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains.

Autor: Hao Y; Department of Chemistry, Georgetown University, Washington, DC, 20057, USA., England JP; Department of Chemistry, Georgetown University, Washington, DC, 20057, USA., Bellucci L; NEST, Istituto Nanoscienze del CNR and Scuola Normale Superiore, Pisa, 56127, Italy., Paci E; Astbury Centre & School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK., Hodges HC; Department of Molecular and Cellular Biology and Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, 77030, USA.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.; Department of Bioengineering, Rice University, Houston, Texas, 77005, USA., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, California, 92093, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, 92093, USA., Maillard RA; Department of Chemistry, Georgetown University, Washington, DC, 20057, USA. rodrigo.maillard@georgetown.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 04; Vol. 10 (1), pp. 3984. Date of Electronic Publication: 2019 Sep 04.

Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers.

Autor: Hao Y; Department of Chemistry, Georgetown University, Washington, DC 20057, USA., Canavan C; Department of Chemistry, Georgetown University, Washington, DC 20057, USA., Taylor SS; Department of Pharmacology & Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA., Maillard RA; Department of Chemistry, Georgetown University, Washington, DC 20057, USA. rodrigo.maillard@georgetown.edu.

Publikováno v: Scientific reports [Sci Rep] 2017 Sep 07; Vol. 7 (1), pp. 10843. Date of Electronic Publication: 2017 Sep 07.