Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin

Autor: Jérôme Goudeau, Leanne Jade G. Chan, David R. Kelley, Maile Tm, Margaret Ann Roy, Fiona E. McAllister, Han Yuan, Cynthia Kenyon, Jonathon J. O’Brien, Bryson Bennett, Levinson Ad, Rebecca Y Wang, Andrea T. Ireland, David Botstein, Robert L. Cohen, David G. Hendrickson, Adam Freund, Vijay T, Ilya Soifer, Chan M

Replicative senescence (RS) as a model has become the central focus of research into cellular aging in vitro. Despite decades of study, this process through which cells cease dividing is not fully understood in culture, and even much less so in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ff87df9d04615398074920fe2da3fea
https://doi.org/10.1101/2021.05.03.442497

Novel insights from a multiomics dissection of the Hayflick limit.

Autor: Chan M; Calico Life Sciences, LLC, South San Francisco, United States., Yuan H; Calico Life Sciences, LLC, South San Francisco, United States., Soifer I; Calico Life Sciences, LLC, South San Francisco, United States., Maile TM; Calico Life Sciences, LLC, South San Francisco, United States., Wang RY; Calico Life Sciences, LLC, South San Francisco, United States., Ireland A; Calico Life Sciences, LLC, South San Francisco, United States., O'Brien JJ; Calico Life Sciences, LLC, South San Francisco, United States., Goudeau J; Calico Life Sciences, LLC, South San Francisco, United States., Chan LJG; Calico Life Sciences, LLC, South San Francisco, United States., Vijay T; Calico Life Sciences, LLC, South San Francisco, United States., Freund A; Calico Life Sciences, LLC, South San Francisco, United States., Kenyon C; Calico Life Sciences, LLC, South San Francisco, United States., Bennett BD; Calico Life Sciences, LLC, South San Francisco, United States., McAllister FE; Calico Life Sciences, LLC, South San Francisco, United States., Kelley DR; Calico Life Sciences, LLC, South San Francisco, United States., Roy M; Calico Life Sciences, LLC, South San Francisco, United States., Cohen RL; Calico Life Sciences, LLC, South San Francisco, United States., Levinson AD; Calico Life Sciences, LLC, South San Francisco, United States., Botstein D; Calico Life Sciences, LLC, South San Francisco, United States., Hendrickson DG; Calico Life Sciences, LLC, South San Francisco, United States.

Publikováno v: ELife [Elife] 2022 Feb 04; Vol. 11. Date of Electronic Publication: 2022 Feb 04.

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

Autor: Vinogradova M; Genentech Inc., South San Francisco, California, USA., Gehling VS; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Gustafson A; Genentech Inc., South San Francisco, California, USA., Arora S; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Tindell CA; Genentech Inc., South San Francisco, California, USA., Wilson C; Genentech Inc., South San Francisco, California, USA., Williamson KE; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Guler GD; Genentech Inc., South San Francisco, California, USA., Gangurde P; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Manieri W; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Busby J; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Flynn EM; Genentech Inc., South San Francisco, California, USA., Lan F; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Kim HJ; Genentech Inc., South San Francisco, California, USA., Odate S; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Cochran AG; Genentech Inc., South San Francisco, California, USA., Liu Y; Genentech Inc., South San Francisco, California, USA., Wongchenko M; Genentech Inc., South San Francisco, California, USA., Yang Y; Genentech Inc., South San Francisco, California, USA., Cheung TK; Genentech Inc., South San Francisco, California, USA., Maile TM; Genentech Inc., South San Francisco, California, USA., Lau T; Genentech Inc., South San Francisco, California, USA., Costa M; Genentech Inc., South San Francisco, California, USA., Hegde GV; Genentech Inc., South San Francisco, California, USA., Jackson E; Genentech Inc., South San Francisco, California, USA., Pitti R; Genentech Inc., South San Francisco, California, USA., Arnott D; Genentech Inc., South San Francisco, California, USA., Bailey C; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Bellon S; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Cummings RT; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Albrecht BK; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Harmange JC; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Kiefer JR; Genentech Inc., South San Francisco, California, USA., Trojer P; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA., Classon M; Genentech Inc., South San Francisco, California, USA.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2016 Jul; Vol. 12 (7), pp. 531-8. Date of Electronic Publication: 2016 May 23.

Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method.

Autor: Maile TM; From the ‡Protein Chemistry Department, Genentech Inc., South San Francisco, California 94080;, Izrael-Tomasevic A; From the ‡Protein Chemistry Department, Genentech Inc., South San Francisco, California 94080;, Cheung T; From the ‡Protein Chemistry Department, Genentech Inc., South San Francisco, California 94080;, Guler GD; §Cancer Targets Department, Genentech, Inc., South San Francisco, California 94080;, Tindell C; §Cancer Targets Department, Genentech, Inc., South San Francisco, California 94080;, Masselot A; ¶Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, California 94080;, Liang J; ‖Discovery Chemistry Department, Genentech, Inc., South San Francisco, California 94080;, Zhao F; *Biology Department, Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts 02142., Trojer P; *Biology Department, Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts 02142., Classon M; §Cancer Targets Department, Genentech, Inc., South San Francisco, California 94080;, Arnott D; From the ‡Protein Chemistry Department, Genentech Inc., South San Francisco, California 94080; arnott@gene.com.

Publikováno v: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2015 Apr; Vol. 14 (4), pp. 1148-58. Date of Electronic Publication: 2015 Feb 13.