VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

Autor: Ann Schirin Mirsanaye, Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca Lopez Mendez, Dimitris Typas, Johannes van den Boom, Bente Benedict, Ivo A. Hendriks, Michael Lund Nielsen, Hemmo Meyer, Julien P. Duxin, Guillermo Montoya, Niels Mailand

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ub

Externí odkaz: https://doaj.org/article/94acc0facb2c40838b11f84474d25e74

Complete inclusion of bioactive molecules and particles in polydime-thylsiloxane: a straightforward process under mild conditions

Autor: Faccio, Greta, Cont, Alice, Mailand, Erik, Zare-Eelanjegh, Elaheh, Malini, Riccardo Innocenti, Maniura-Weber, Katharina, Rossi, René Michel, Spano, Fabrizio

By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, p

Externí odkaz: http://arxiv.org/abs/1907.09710

Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy

Autor: Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.

Externí odkaz: https://doaj.org/article/bfe3845b80824c5996d10d21e1575e9d

The Sensitivity of the Advanced LIGO Detectors at the Beginning of Gravitational Wave Astronomy

Autor: Martynov, D. V., Hall, E. D., Abbott, B. P., Abbott, R., Abbott, T. D., Adams, C., Adhikari, R. X., Anderson, R. A., Anderson, S. B., Arai, K., Arain, M. A., Aston, S. M., Austin, L., Ballmer, S. W., Barbet, M., Barker, D., Barr, B., Barsotti, L., Bartlett, J., Barton, M. A., Bartos, I., Batch, J. C., Bell, A. S., Belopolski, I., Bergman, J., Betzwieser, J., Billingsley, G., Birch, J., Biscans, S., Biwer, C., Black, E., Blair, C. D., Bogan, C., Bond, C., Bork, R., Bridges, D. O., Brooks, A. F., Brown, D. D., Carbone, L., Celerier, C., Ciani, G., Clara, F., Cook, D., Countryman, S. T., Cowart, M. J., Coyne, D. C., Cumming, A., Cunningham, L., Damjanic, M., Dannenberg, R., Danzmann, K., Costa, C. F. Da Silva, Daw, E. J., DeBra, D., DeRosa, R. T., DeSalvo, R., Dooley, K. L., Doravari, S., Driggers, J. C., Dwyer, S. E., Effler, A., Etzel, T., Evans, M., Evans, T. M., Factourovich, M., Fair, H., Feldbaum, D., Fisher, R. P., Foley, S., Frede, M., Freise, A., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Galdi, V., Giaime, J. A., Giardina, K. D., Gleason, J. R., Goetz, R., Gras, S., Gray, C., Greenhalgh, R. J. S., Grote, H., Guido, C. J., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Hammond, G., Hanks, J., Hanson, J., Hardwick, T., Harry, G. M., Haughian, K., Heefner, J., Heintze, M. C., Heptonstall, A. W., Hoak, D., Hough, J., Ivanov, A., Izumi, K., Jacobson, M., James, E., Jones, R., Kandhasamy, S., Karki, S., Kasprzack, M., Kaufer, S., Kawabe, K., Kells, W., Kijbunchoo, N., King, E. J., King, P. J., Kinzel, D. L., Kissel, J. S., Kokeyama, K., Korth, W. Z., Kuehn, G., Kwee, P., Landry, M., Lantz, B., Roux, A. Le, Levine, B. M., Lewis, J. B., Lhuillier, V., Lockerbie, N. A., Lormand, M., Lubinski, M. J., Lundgren, A. P., MacDonald, T., MacInnis, M., Macleod, D. M., Mageswaran, M., Mailand, K., M'arka, S., M'arka, Z., Markosyan, A. S., Maros, E., Martin, I. W., Martin, R. M., Marx, J. N., Mason, K., Massinger, T. J., Matichard, F., Mavalvala, N., McCarthy, R., McClelland, D. E., McCormick, S., McIntyre, G., McIver, J., Merilh, E. L., Meyer, M. S., Meyers, P. M., Miller, J., Mittleman, R., Moreno, G., Mueller, C. L., Mueller, G., Mullavey, A., Munch, J., Murray, P. G., Nuttall, L. K., Oberling, J., O'Dell, J., Oppermann, P., Oram, Richard J., O'Reilly, B., Osthelder, C., Ottaway, D. J., Overmier, H., Palamos, J. R., Paris, H. R., Parker, W., Patrick, Z., Pele, A., Penn, S., Phelps, M., Pickenpack, M., Piero, V., Pinto, I., Poeld, J., Principe, M., Prokhorov, L., Puncken, O., Quetschke, V., Quintero, E. A., Raab, F. J., Radkins, H., Raffai, P., Ramet, C. R., Reed, C. M., Reid, S., Reitze, D. H., Robertson, N. A., Rollins, J. G., Roma, V. J., Romie, J. H., Rowan, S., Ryan, K., Sadecki, T., Sanchez, E. J., Sandberg, V., Sannibale, V., Savage, R. L., Schofield, R. M. S., Schultz, B., Schwinberg, P., Sellers, D., Sevigny, A., Shaddock, D. A., Shao, Z., Shapiro, B., Shawhan, P., Shoemaker, D. H., Sigg, D., Slagmolen, B. J. J., Smith, J. R., Smith, M. R., Smith-Lefebvre, N. D., Sorazu, B., Staley, A., Stein, A. J., Stochino, A., Strain, K. A., Taylor, R., Thomas, M., Thomas, P., Thorne, K. A., Thrane, E., Tokmakov, K. V., Torrie, C. I., Traylor, G., Vajente, G., Valdes, G., van Veggel, A. A., Vargas, M., Vecchio, A., Veitch, P. J., Venkateswara, K., Vo, T., Vorvick, C., Waldman, S. J., Walker, M., Ward, R. L., Warner, J., Weaver, B., Weiss, R., Welborn, T., Wessels, P., Wilkinson, C., Willems, P. A., Williams, L., Willke, B., Wilmut, I., Winkelmann, L., Wipf, C. C., Worden, J., Wu, G., Yamamoto, H., Yancey, C. C., Yu, H., Zhang, L., Zucker, M. E., Zweizig, J.

Publikováno v: Phys. Rev. D 93, 112004 (2016)

The Laser Interferometer Gravitational Wave Observatory (LIGO) consists of two widely separated 4 km laser interferometers designed to detect gravitational waves from distant astrophysical sources in the frequency range from 10 Hz to 10 kHz. The firs

Externí odkaz: http://arxiv.org/abs/1604.00439

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