Výsledky vyhledávání - "Maiko TANAKA"

Akademický článek

Novel beta-glucocerebrosidase chaperone compounds identified from cell-based screening reduce pathologically accumulated glucosylsphingosine in iPS-derived neuronal cells

Autor: Yusuke Naito, Sou Sakamoto, Takuto Kojima, Misaki Homma, Maiko Tanaka, Hideki Matsui

Publikováno v: SLAS Discovery, Vol 28, Iss 7, Pp 344-349 (2023)

The beta-glucocerebrosidase (GBA1) gene encodes the lysosomal beta-glucocerebrosidase (GCase) that metabolizes the lipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph). Biallelic loss-of-function mutations in GBA1 such as L444P cause Gau

Externí odkaz: https://doaj.org/article/6fa5022fc3904bd99b6d9e7cc05d8004

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Akademický článek

Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration.

Autor: Naoto Arimura, Chie Maeda, Kazunobu Aoyama, Namiko Yamaguchi, Ayumu Sugiura, Yasuko Takahashi, Ryouta Maeda, Tatsuya Ando, Makoto Kamata, Hideki Matsui, Maiko Tanaka

Publikováno v: PLoS ONE, Vol 19, Iss 11, p e0312090 (2024)

Neuroinflammation, a hallmark of neurodegenerative diseases, is associated with neuronal cell loss and cognitive dysfunction. Monoacylglycerol lipase (MAGL) is involved in neuroinflammation in the brain via the degradation of endocannabinoid 2-arachi

Externí odkaz: https://doaj.org/article/da539045f81b4b218e54f2c48e7073c9

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Akademický článek

Pustular eruption on the palms and soles associated with zinc allergy and perspiration

Autor: Yukiko Naito, MD, PhD, Shunji Matsumura, MD, Yoshinori Hada, DDS, Maiko Tanaka, MD, PhD, Shunsuke Takahagi, MD, PhD, Michihiro Hide, MD, PhD

Publikováno v: JAAD Case Reports, Vol 36, Iss , Pp 92-95 (2023)

Externí odkaz: https://doaj.org/article/d31e4c76f9e547b9b5d65b6f2c51f799

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Akademický článek

A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in mice

Autor: Tomohiro Onishi, Ryouta Maeda, Michiko Terada, Sho Sato, Takahiro Fujii, Masahiro Ito, Kentaro Hashikami, Tomohiro Kawamoto, Maiko Tanaka

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are collectively termed tauopathies. Tau pathology is associated with axo

Externí odkaz: https://doaj.org/article/67cf6d93ad1a49af82682f07692cec8c

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Akademický článek

Long‐term remission of severe livedoid vasculopathy treated with a short course of intravenous immunoglobulin

Autor: Shunsuke Takahagi, Maiko Tanaka, Satoshi Morioke, Masataka Suehiro, Akio Tanaka, Michihiro Hide

Publikováno v: Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 6, Pp 189-190 (2021)

Externí odkaz: https://doaj.org/article/d2c41ae016b04085857b815723535443

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Akademický článek

Balloon Cell Malignant Melanoma in a Young Female: A Case Report and Review of the Literature

Autor: Yui Hattori, Kazuhiro Sentani, Takuya Hattori, Yoshimi Matsuo, Mikio Kawai, Hajime Shindo, Maiko Tanaka, Michihiro Hide, Wataru Yasui

Publikováno v: Case Reports in Oncology, Vol 9, Iss 1, Pp 262-266 (2016)

Balloon cell malignant melanoma (BCMM) is a very rare malignant melanoma subtype. The clinical appearance of BCMM varies; it may be nodular, ulcerated, polypoid, papillomatous and often non-pigmented. The tumor cells histologically appear large, poly

Externí odkaz: https://doaj.org/article/33b3da63a410419f8726030e601538a5

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Akademický článek

Correction: Hexameric and pentameric complexes of the ExbBD energizer in the Ton system

Autor: Koji Yonekura, Saori Maki-Yonekura, Rei Matsuoka, Yoshiki Yamashita, Hirofumi Shimizu, Maiko Tanaka, Fumie Iwabuki

Publikováno v: eLife, Vol 7 (2018)

Externí odkaz: https://doaj.org/article/066c88fa933e4ff2a7c8a4dcf08cb1ff

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Akademický článek

Hexameric and pentameric complexes of the ExbBD energizer in the Ton system

Autor: Saori Maki-Yonekura, Rei Matsuoka, Yoshiki Yamashita, Hirofumi Shimizu, Maiko Tanaka, Fumie Iwabuki, Koji Yonekura

Publikováno v: eLife, Vol 7 (2018)

Gram-negative bacteria import essential nutrients such as iron and vitamin B12 through outer membrane receptors. This process utilizes proton motive force harvested by the Ton system made up of three inner membrane proteins, ExbB, ExbD and TonB. ExbB

Externí odkaz: https://doaj.org/article/063cb9d86682433aaf2862e8afc81584

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