Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maiko Hamada"'
Publikováno v:
RSC Adv.. 4:23131-23136
A novel and efficient method for the selective monobenzoylation of N-Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc)2 and Cs2CO3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557ee089819c355f6660d93dc5ee0825
https://doi.org/10.1039/c4ra02401j
https://doi.org/10.1039/c4ra02401j
Autor:
Kunitomo Adachi, Mahoko Asayama, Noriko Sato, Maiko Hamada, Kunio Sugahara, Mitsuharu Nakamura, Kaoru Marukawa, Ayumi Tomatsu, Masatoshi Kiuchi, Kyoko Shimano, Kan Takagi
Publikováno v:
Journal of Medicinal Chemistry. 53:3154-3168
A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P(1)) receptor agonists with potent immunomodulatory activity accompanied by littl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf476da0a95a4d40f3dc7c1ce601a3f8
https://doi.org/10.1021/jm901776q
https://doi.org/10.1021/jm901776q
Autor:
Koichi Oshita, Shinsuke Ooike, Kunitomo Adachi, Naoto Fujie, Kunio Sugahara, Hidemasa Hikawa, Endo Junichi, Naoki Sugiyama, Kazunori Iwata, Maiko Hamada, Seigo Ishibuchi, Meguru Murata, Kenji Chiba, Haruhito Kobayashi, Minoru Tanaka, Hiroshi Sumichika
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(5)
A phenotypic screening of thienodiazepines derived from a hit compound found through a binding assay targeting co-stimulatory molecules on T cells and antigen presenting cells successfully led to the discovery of a thienotriazolodiazepine compound (7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c72a7aa20024a2afb51c8b7aa67521
https://pubmed.ncbi.nlm.nih.gov/26869194
https://pubmed.ncbi.nlm.nih.gov/26869194
Publikováno v:
ChemInform. 46
A novel and efficient method for the selective monobenzoylation of N-Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc)2 and Cs2CO3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a197772a5bb41d2874ba7c7ccdf74c
https://doi.org/10.1002/chin.201501052
https://doi.org/10.1002/chin.201501052
Publikováno v:
Chemicalpharmaceutical bulletin. 62(10)
A method for enantioselective desymmetrization of N-Ac and N-Boc-FTY720 by nonenzymatic asymmetric acylation was developed. Effective enantioselective monobenzoylation using benzoyl chloride in the presence of the tetraphenylbisoxazoline (L2)-CuCl2 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d75f444685a9056a6c27e9f5819dc4d
https://pubmed.ncbi.nlm.nih.gov/25273063
https://pubmed.ncbi.nlm.nih.gov/25273063
Publikováno v:
Synthesis. 2007:1927-1929
A practical and concise synthesis of KRP-203 ( 1) was achieved by utilizing a palladium coupling reaction mediated by XantPhos and Pd 2 (dba) 3 as the key step. The coupling reaction of aryl bromide 5 with 3-hydroxythiophenol ( 6) proceeded chemosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f4eca90a5667032ac7ab66cf7eaf9b
https://doi.org/10.1055/s-2007-983721
https://doi.org/10.1055/s-2007-983721
Publikováno v:
Chemicalpharmaceutical bulletin. 60(11)
A concise synthesis of a useful intermediate 10 for the preparation of fingolimod (FTY-720) analogs was achieved by utilizing a chemoselective Sonogashira reaction of trihalobenzene 12 with alkyne 13. The reaction proceeded with high selectivity to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f9403016e9c2239f8d0c0b10614396
https://pubmed.ncbi.nlm.nih.gov/23124563
https://pubmed.ncbi.nlm.nih.gov/23124563