Zobrazeno 1 - 10
of 707
pro vyhledávání: '"Maikel P. Peppelenbosch"'
Autor:
Bingting Yu, Danny de Vos, Xiaopei Guo, SanFei Peng, Wenjie Xie, Maikel P. Peppelenbosch, Yang Fu, Gwenny M. Fuhler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 50, Iss , Pp 100981- (2024)
Purpose: Helicobacter pylori (H. pylori) is a significant risk factor for development of gastric cancer (GC), one of the deadliest malignancies in the world. However, the mechanism by which H. pylori induces gastric oncogenesis remains unclear. Here,
Externí odkaz:
https://doaj.org/article/68f1358d78a047de9bd9713d42bbc593
Autor:
Yining Wang, Pengfei Li, Lei Xu, Annemarie C. de Vries, Robbert J. Rottier, Wenshi Wang, Marie-Rose B.S. Crombag, Maikel P. Peppelenbosch, Denis E. Kainov, Qiuwei Pan
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107631- (2023)
Summary: Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral agents library, we
Externí odkaz:
https://doaj.org/article/3c450ae729b5427c905f4ff5c8cccb02
Autor:
Ruby Lieshout, Alessandra V. S. Faria, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Monique M. A. Verstegen, Gwenny M. Fuhler
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular si
Externí odkaz:
https://doaj.org/article/383639e6c871433fabdfa2e494969105
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPrevious evidence indicated that Helicobacter pylori-induced inflammation is the first step towards gastric carcinogenesis. However, investigations of the immunological factors driving this process have shown inconsistencies. We aimed to pr
Externí odkaz:
https://doaj.org/article/9aa7e7fb24714de2a325a879c8b38bce
Autor:
Shanshan Li, Ruyi Zhang, Marla Lavrijsen, Thierry P. P. van den Bosch, Maikel P. Peppelenbosch, Ron Smits
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
RNF43 is an important negative regulator of β-catenin signaling by removing Wnt-receptors from the membrane. It is often mutated in cancers, leading to aberrant Wnt-dependent nuclear translocation of β-catenin. RNF43 has also been suggested to regu
Externí odkaz:
https://doaj.org/article/afff1c17ad47456281d92ba6fdb5059d
Autor:
Ibrahim Ayada, Laurens A. van Kleef, Huai Zhang, Kuan Liu, Pengfei Li, Yasir J. Abozaid, Marla Lavrijsen, Harry L.A. Janssen, Luc J.W. van der Laan, Mohsen Ghanbari, Maikel P. Peppelenbosch, Ming-Hua Zheng, Robert J. de Knegt, Qiuwei Pan
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104392- (2023)
Summary: Background: Statin use could benefit patients with non-alcoholic fatty liver disease (NAFLD), but the evidence is segmented and inconclusive. This multidimensional study comprehensively investigated the potential benefits and mechanism-of-ac
Externí odkaz:
https://doaj.org/article/53dc9352264d4b47883067a90fed6042
Autor:
Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzmán, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the
Externí odkaz:
https://doaj.org/article/469f4cbf24264d01b938927512f6b9a2
Autor:
Pengfei Li, Yining Wang, Mart M. Lamers, Marla Lavrijsen, Cinta Iriondo, Annemarie C. de Vries, Robbert J. Rottier, Maikel P. Peppelenbosch, Bart L. Haagmans, Qiuwei Pan
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104132- (2022)
Summary: Background: Human seasonal coronaviruses usually cause mild upper-respiratory tract infection, but severe complications can occur in specific populations. Research into seasonal coronaviruses is limited and robust experimental models are lar
Externí odkaz:
https://doaj.org/article/2676a7790fca407aa60d424b50478ea3
Autor:
Yuxin Su, Junhong Su, Fanglin Li, Xiaojing Tian, Zewen Liu, Gongtao Ding, Jialin Bai, Zhuo Li, Zhongren Ma, Maikel P. Peppelenbosch
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
The yak (Bos grunniens) is closely related to common cows (Bos taurus), but is clearly a distinct species. Yaks are of substantial importance to food and leather production in certain high-altitude regions of Asia. The animal is increasing elsewhere
Externí odkaz:
https://doaj.org/article/34ca2f8b23da4fd7bc6755902068558d
Autor:
Wenhui Wang, Pengyu Liu, Marla Lavrijsen, Shan Li, Ruyi Zhang, Shanshan Li, Wesley S. van de Geer, Harmen J. G. van de Werken, Maikel P. Peppelenbosch, Ron Smits
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract AXIN1 mutations are observed in 8–10% of hepatocellular carcinomas (HCCs) and originally were considered to support tumor growth by aberrantly enhancing β-catenin signaling. This view has however been challenged by reports showing neither
Externí odkaz:
https://doaj.org/article/d777e74f205b42679a788f43c00cff6c