Zobrazeno 1 - 10
of 718
pro vyhledávání: '"Maikel P Peppelenbosch"'
Autor:
Changbo Qu, Jinyu Zhao, Jicai Lai, Xinxiang Wu, Peng Huang, Ting Zhu, Yan Li, Taoli Liu, Jinqiu Yuan, Ning Wang, Maikel P Peppelenbosch, Hongda Chen, Bin Xia, Jian Qin
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular complications, neurological manifestations and poor wound healing. Adhering to a Mediterranean Diet (MED) is generally considered an
Externí odkaz:
https://doaj.org/article/c6bd8c26d06745f7a9f8edc07b23dd63
Autor:
Marco J Bruno, Kaatje Lenaerts, Eline S van Hattum, Jaap F Hamming, Olaf J Bakker, Ron Balm, Maarten J van der Laan, Gert Jan de Borst, Mathias Clarysse, Laurens J Ceulemans, Adriaan Moelker, Dammis Vroegindeweij, Robert H Geelkerken, Jeroen J Kolkman, Désirée van Noord, Maikel P Peppelenbosch, Hence J M Verhagen, Joep P M Derikx, Annet A M Duivenvoorden, Jean-Paul P M de Vries, Hessel C J L Buscher, Steven W M Olde Damink, Frederik Jan van Schooten, Tim Lubbers, Juliette T Blauw, Louisa J D van Dijk, Bram Fioole, Jihan Harki, Daniel A F van den Heuvel, Jan Willem Hinnen, André S van Petersen, Pepijn Rijnja, Peter J van der Schaar, Luke G Terlouw
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction Acute mesenteric ischaemia (AMI) is a life-threatening condition with short-term mortality of up to 80%. The diagnosis of AMI has remained troublesome due to the non-specific clinical presentation, symptoms and laboratory findings. Early
Externí odkaz:
https://doaj.org/article/9146b7dd9b6f4d338bd026d5743c25ce
Autor:
Shanshan Li, Ruyi Zhang, Marla Lavrijsen, Thierry P P van den Bosch, Maikel P Peppelenbosch, Ron Smits
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283894 (2023)
RNF43 is an important negative regulator of β-catenin signaling by removing Wnt-receptors from the membrane. It is often mutated in cancers, leading to aberrant Wnt-dependent nuclear translocation of β-catenin. RNF43 has also been suggested to regu
Externí odkaz:
https://doaj.org/article/ffaa57bf4ed741ac98bf2cf01f42c568
Publikováno v:
The Lancet Global Health, Vol 8, Iss 4, Pp e480- (2020)
Externí odkaz:
https://doaj.org/article/8cd671d534604693ab371a4b657a9401
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008017 (2019)
As the central dogma of molecular biology, genetic information flows from DNA through transcription into RNA followed by translation of the message into protein by transfer RNAs (tRNAs). However, mRNA translation is not always perfect, and errors in
Externí odkaz:
https://doaj.org/article/04a32350eab54a468563d293a4440387
Autor:
Edyta Korbut, Vincent T Janmaat, Mateusz Wierdak, Jerzy Hankus, Dagmara Wójcik, Marcin Surmiak, Katarzyna Magierowska, Tomasz Brzozowski, Maikel P Peppelenbosch, Marcin Magierowski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6436 (2020)
Barrett’s esophagus (BE) is a premalignant condition caused by gastroesophageal reflux disease (GERD), where physiological squamous epithelium is replaced by columnar epithelium. Several in vivo and in vitro BE models were developed with questionab
Externí odkaz:
https://doaj.org/article/57e2af1037e2465d940a0718935134a9
Autor:
Hester Eppinga, H Bing Thio, Marco W J Schreurs, Blerdi Blakaj, Ruena I Tahitu, Sergey R Konstantinov, Maikel P Peppelenbosch, Gwenny M Fuhler
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176955 (2017)
Psoriasis and inflammatory bowel disease (IBD) are chronic inflammatory diseases sharing similar pathogenic pathways. Intestinal microbial changes such as a decrease of bakers' yeast Saccharomyces cerevisiae have been reported in IBD, suggesting the
Externí odkaz:
https://doaj.org/article/ce17f18d925e422082735e0c893b11a6
Autor:
Rajesh Somasundaram, Sandra Fernandes, Jasper J Deuring, Colin de Haar, Ernst J Kuipers, Lauran Vogelaar, Frank A Middleton, C Janneke van der Woude, Maikel P Peppelenbosch, William G Kerr, Gwenny M Fuhler
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182308 (2017)
SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytok
Externí odkaz:
https://doaj.org/article/438601c795fd434ca47b09f3b310e90a
Autor:
Vincent T Janmaat, Marco J Bruno, Suzanne Polinder, Sylvie Lorenzen, Florian Lordick, Maikel P Peppelenbosch, Manon C W Spaander
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153943 (2016)
BACKGROUND:Costly biologicals in palliative oncology are emerging at a rapid pace. For example, in patients with advanced esophageal squamous cell carcinoma addition of cetuximab to a palliative chemotherapy regimen appears to improve survival. Howev
Externí odkaz:
https://doaj.org/article/f49d8019851645abbe089e2d15447dde
Autor:
Juan Li, Pratika Y Hernanda, Wichor M Bramer, Maikel P Peppelenbosch, Judith van Luijk, Qiuwei Pan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127967 (2015)
Several studies have reported that metformin can reduce the risk of hepatocellular carcinoma (HCC) in diabetes patients. However, the direct anti-HCC effects of metformin have hardly been studied in patients, but have been extensively investigated in
Externí odkaz:
https://doaj.org/article/03a8cce1bd1340f48493c76a001672bb