Zobrazeno 1 - 10
of 970
pro vyhledávání: '"Maikel P Peppelenbosch"'
Autor:
Changbo Qu, Jinyu Zhao, Jicai Lai, Xinxiang Wu, Peng Huang, Ting Zhu, Yan Li, Taoli Liu, Jinqiu Yuan, Ning Wang, Maikel P Peppelenbosch, Hongda Chen, Bin Xia, Jian Qin
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular complications, neurological manifestations and poor wound healing. Adhering to a Mediterranean Diet (MED) is generally considered an
Externí odkaz:
https://doaj.org/article/c6bd8c26d06745f7a9f8edc07b23dd63
Autor:
Bingting Yu, Danny de Vos, Xiaopei Guo, SanFei Peng, Wenjie Xie, Maikel P. Peppelenbosch, Yang Fu, Gwenny M. Fuhler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 50, Iss , Pp 100981- (2024)
Purpose: Helicobacter pylori (H. pylori) is a significant risk factor for development of gastric cancer (GC), one of the deadliest malignancies in the world. However, the mechanism by which H. pylori induces gastric oncogenesis remains unclear. Here,
Externí odkaz:
https://doaj.org/article/68f1358d78a047de9bd9713d42bbc593
Autor:
Yining Wang, Pengfei Li, Lei Xu, Annemarie C. de Vries, Robbert J. Rottier, Wenshi Wang, Marie-Rose B.S. Crombag, Maikel P. Peppelenbosch, Denis E. Kainov, Qiuwei Pan
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107631- (2023)
Summary: Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral agents library, we
Externí odkaz:
https://doaj.org/article/3c450ae729b5427c905f4ff5c8cccb02
Autor:
Marco J Bruno, Kaatje Lenaerts, Eline S van Hattum, Jaap F Hamming, Olaf J Bakker, Ron Balm, Maarten J van der Laan, Gert Jan de Borst, Mathias Clarysse, Laurens J Ceulemans, Adriaan Moelker, Dammis Vroegindeweij, Robert H Geelkerken, Jeroen J Kolkman, Désirée van Noord, Maikel P Peppelenbosch, Hence J M Verhagen, Joep P M Derikx, Annet A M Duivenvoorden, Jean-Paul P M de Vries, Hessel C J L Buscher, Steven W M Olde Damink, Frederik Jan van Schooten, Tim Lubbers, Juliette T Blauw, Louisa J D van Dijk, Bram Fioole, Jihan Harki, Daniel A F van den Heuvel, Jan Willem Hinnen, André S van Petersen, Pepijn Rijnja, Peter J van der Schaar, Luke G Terlouw
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction Acute mesenteric ischaemia (AMI) is a life-threatening condition with short-term mortality of up to 80%. The diagnosis of AMI has remained troublesome due to the non-specific clinical presentation, symptoms and laboratory findings. Early
Externí odkaz:
https://doaj.org/article/9146b7dd9b6f4d338bd026d5743c25ce
Autor:
Ruby Lieshout, Alessandra V. S. Faria, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Monique M. A. Verstegen, Gwenny M. Fuhler
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular si
Externí odkaz:
https://doaj.org/article/383639e6c871433fabdfa2e494969105
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPrevious evidence indicated that Helicobacter pylori-induced inflammation is the first step towards gastric carcinogenesis. However, investigations of the immunological factors driving this process have shown inconsistencies. We aimed to pr
Externí odkaz:
https://doaj.org/article/9aa7e7fb24714de2a325a879c8b38bce
Autor:
Shanshan Li, Ruyi Zhang, Marla Lavrijsen, Thierry P P van den Bosch, Maikel P Peppelenbosch, Ron Smits
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283894 (2023)
RNF43 is an important negative regulator of β-catenin signaling by removing Wnt-receptors from the membrane. It is often mutated in cancers, leading to aberrant Wnt-dependent nuclear translocation of β-catenin. RNF43 has also been suggested to regu
Externí odkaz:
https://doaj.org/article/ffaa57bf4ed741ac98bf2cf01f42c568
Autor:
Ibrahim Ayada, Laurens A. van Kleef, Huai Zhang, Kuan Liu, Pengfei Li, Yasir J. Abozaid, Marla Lavrijsen, Harry L.A. Janssen, Luc J.W. van der Laan, Mohsen Ghanbari, Maikel P. Peppelenbosch, Ming-Hua Zheng, Robert J. de Knegt, Qiuwei Pan
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104392- (2023)
Summary: Background: Statin use could benefit patients with non-alcoholic fatty liver disease (NAFLD), but the evidence is segmented and inconclusive. This multidimensional study comprehensively investigated the potential benefits and mechanism-of-ac
Externí odkaz:
https://doaj.org/article/53dc9352264d4b47883067a90fed6042
Autor:
Xiaopei Guo, Marco W. J. Schreurs, Fleur E. Marijnissen, Michiel C. Mommersteeg, Stella A. V. Nieuwenburg, Michail Doukas, Nicole S. Erler, Lisette G. Capelle, Marco J. Bruno, Maikel P. Peppelenbosch, Manon C. W. Spaander, Gwenny M. Fuhler
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 19, p 6152 (2023)
Background: Autoimmune gastritis (AIG), characterized with the presence of anti-parietal-cell antibodies (APCA), is a risk factor for gastric cancer. However, AIG may go underdiagnosed, especially in the case of H. pylori infection and the presence o
Externí odkaz:
https://doaj.org/article/1ace73f13523496a90f98d35831400cd
Autor:
Iris J. M. Levink, Maurice P. H. M. Jansen, Zakia Azmani, Wilfred van IJcken, Ronald van Marion, Maikel P. Peppelenbosch, Djuna L. Cahen, Gwenny M. Fuhler, Marco J. Bruno
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13116 (2023)
Molecular profiling may enable earlier detection of pancreatic cancer (PC) in high-risk individuals undergoing surveillance and allow for personalization of treatment. We hypothesized that the detection rate of DNA mutations is higher in pancreatic j
Externí odkaz:
https://doaj.org/article/9141d1c9956f48ecbeb167a3869dda97