Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Maike Bublitz"'
Autor:
Kamel El Omari, Nada Mohamad, Kiran Bountra, Ramona Duman, Maria Romano, Katja Schlegel, Hok-Sau Kwong, Vitaliy Mykhaylyk, Claus Olesen, Jesper Vuust Moller, Maike Bublitz, Konstantinos Beis, Armin Wagner
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1092-1101 (2020)
The structure determination of soluble and membrane proteins can be hindered by the crystallographic phase problem, especially in the absence of a suitable homologous structure. Experimental phasing is the method of choice for novel structures; howev
Externí odkaz:
https://doaj.org/article/97406e4f17cc4e1cac866e06b368fa63
Autor:
Maike Bublitz, Lasse Kjellerup, Karen O'Hanlon Cohrt, Sandra Gordon, Anne Louise Mortensen, Johannes D Clausen, Thomas David Pallin, John Bondo Hansen, Anja Thoe Fuglsang, William Dalby-Brown, Anne-Marie L Winther
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0188620 (2018)
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data and computation
Externí odkaz:
https://doaj.org/article/e2b6d98723684c38a8ade703a93f35c5
Autor:
Maike Bublitz, Karol Nass, Nikolaj D. Drachmann, Anders J. Markvardsen, Matthias J. Gutmann, Thomas R. M. Barends, Daniel Mattle, Robert L. Shoeman, R. Bruce Doak, Sébastien Boutet, Marc Messerschmidt, Marvin M. Seibert, Garth J. Williams, Lutz Foucar, Linda Reinhard, Oleg Sitsel, Jonas L. Gregersen, Johannes D. Clausen, Thomas Boesen, Kamil Gotfryd, Kai-Tuo Wang, Claus Olesen, Jesper V. Møller, Poul Nissen, Ilme Schlichting
Publikováno v:
IUCrJ, Vol 2, Iss 4, Pp 409-420 (2015)
Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently, membrane proteins are targeted by a large number of currently approved drugs. Understanding th
Externí odkaz:
https://doaj.org/article/0eb55fd648bc4163964e04aef172633f
Autor:
Julius K, Demmer, Ben P, Phillips, O Lisa, Uhrig, Alain, Filloux, Luke P, Allsopp, Maike, Bublitz, Thomas, Meier
Publikováno v:
Science advances. 8(7)
The global spread of multidrug-resistant
Autor:
Julius K. Demmer, Ben P. Phillips, O. Lisa Uhrig, Alain Filloux, Luke P. Allsopp, Maike Bublitz, Thomas Meier
The global spread of multidrug-resistant Acinetobacter baumannii infections urgently calls for the identification of novel drug targets. We solved the electron cryo-microscopy structure of the F 1 F o –adenosine 5′-triphosphate (ATP) synthase fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8cf5b9068fd7cf5e9bad70be35b739
http://hdl.handle.net/10044/1/94438
http://hdl.handle.net/10044/1/94438
Autor:
Werner Kühlbrandt, Maxwell M. G. Geurts, Sabine Heit, Deryck J. Mills, Bonnie J. Murphy, Maike Bublitz, Robin A. Corey
Publikováno v:
Science Advances
Description
The structure of the hexameric fungal proton pump Pma1 reveals its mechanism of autoinhibition and interactions with lipids.
The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that driv
The structure of the hexameric fungal proton pump Pma1 reveals its mechanism of autoinhibition and interactions with lipids.
The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that driv
Acinetobacter baumannii is a clinically relevant pathogen which causes multi-drug resistant, hospital-acquired infections and is a top priority target for antibiotic development. Cryo-EM structures of the A. baumannii F1Fo-ATP synthase in three confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a575a3b73f3d719a9520891da92d650f
https://doi.org/10.1101/2021.07.10.451757
https://doi.org/10.1101/2021.07.10.451757
Autor:
Maike Bublitz, Bonnie J. Murphy, Sabine Heit, Deryck J. Mills, Robin A. Corey, Maxwell M. G. Geurts, Werner Kühlbrandt
The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that drives the import of essential nutrients. Auto-inhibited Pma1 hexamers in starving fungi are activated by glucose signalling resulting in phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45467e3798c2ee6c864e9fb11019e93c
https://doi.org/10.1101/2021.04.30.442159
https://doi.org/10.1101/2021.04.30.442159
Autor:
Federica Rizzi, Maike Bublitz, William Dalby-Brown, Anne-Marie Lund Winter, Paolo Sportoletti, Anna Montanaro, Donatella Stilli, Giovanni Roti, Luca Pagliaro, Kimberly Stegmaier, Samuel Kitara, Matteo Marchesini, Andrea Gherli, Cristina Mecucci
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S263-S264
The discovery of the P-type ATPase sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) as a modulator of oncogenic NOTCH1 suggests an innovative approach for treating T-cell acute lymphoblastic leukemia (T-ALL). In fact, SERCA inhibition preferent
Autor:
Jason Crain, Patrick W. Simcock, Phillip J. Stansfeld, Flaviu Cipcigan, Maxim G. Ryadnov, Mark S.P. Sansom, Maike Bublitz
Peptide interactions with lipid bilayers play a key role in a range of biological processes and depend on electrostatic interactions between charged amino acids and lipid headgroups. Antimicrobial peptides (AMPs) initiate the killing of bacteria by b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8565b4e4852ff1a5599ea010a174bf
https://doi.org/10.1021/acs.jctc.0c01025
https://doi.org/10.1021/acs.jctc.0c01025