Mitochondrial Creatine Kinase 2 (Ckmt2) as a Plasma-Based Biomarker for Evaluating Reperfusion Injury in Acute Myocardial Infarction

Autor: Alexander Lang, Daniel Oehler, Marcel Benkhoff, Yvonne Reinders, Maike Barcik, Khatereh Shahrjerdi, Madlen Kaldirim, Albert Sickmann, Lisa Dannenberg, Amin Polzin, Susanne Pfeiler, Malte Kelm, Maria Grandoch, Christian Jung, Norbert Gerdes

Publikováno v: Biomedicines, Vol 12, Iss 10, p 2368 (2024)

Background/Objectives: Acute myocardial infarction (AMI), characterized by irreversible heart muscle damage and impaired cardiac function caused by myocardial ischemia, is a leading cause of global mortality. The damage associated with reperfusion, p

Externí odkaz: https://doaj.org/article/d1ed960cc82248259f46c1e3484df36f

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

Autor: Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau

Publikováno v: ESC Heart Failure, Vol 10, Iss 1, Pp 334-341 (2023)

Abstract Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury. However, its impact on post‐ischaemic remodelling indepe

Externí odkaz: https://doaj.org/article/ff12a4b41a044c2dbe150ec1060b1b94

Risk prediction of bleeding and MACCE by PRECISE-DAPT score post-PCI

Autor: Lisa Dannenberg, Shazia Afzal, Natalia Czychy, René M'Pembele, Saif Zako, Carolin Helten, Philipp Mourikis, Dorothee Zikeli, Samantha Ahlbrecht, Kajetan Trojovsky, Marcel Benkhoff, Maike Barcik, Georg Wolff, Tobias Zeus, Malte Kelm, Amin Polzin

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 33, Iss , Pp 100750- (2021)

Background: Guidelines recommend the PRECISE-DAPT (PD) score to adapt duration of dual antiplatelet therapy due to bleeding risk. However, there is first evidence that PD predicts mortality and ischemic events as well. Methods: We investigated PD Sco

Externí odkaz: https://doaj.org/article/9ffe6d3ec2e0477eb6d2f68b7ff59b88

Optogenetic control of mGluR1 signaling modulates synaptic plasticity and cerebellum driven learning

Autor: Tatjana Surdin, Michelle Grömmke, Hanna Böke, Maike Barcik, Zohre Azimi, Dirk Jancke, Stefan Herlitze, Melanie Mark, Ida Siveke

Neuronal plasticity underlying cerebellar learning behavior is strongly associated with type 1 metabotropic glutamate receptor (mGluR1) signaling. This receptor is located at perisynaptic sites at cerebellar Purkinje cells (PCs) and detects glutamate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21f4e6dfaeb9ccae43bb21d342de7da6
https://doi.org/10.21203/rs.3.rs-1344254/v1

Risk prediction of bleeding and MACCE by PRECISE-DAPT score post-PCI

Autor: Marcel Benkhoff, René M'Pembele, Philipp Mourikis, Georg Wolff, Lisa Dannenberg, Amin Polzin, Tobias Zeus, Maike Barcik, Natalia Czychy, Dorothee Zikeli, Saif Zako, Malte Kelm, Carolin Helten, Shazia Afzal, Kajetan Trojovsky, Samantha Ahlbrecht

Publikováno v: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 33, Iss, Pp 100750-(2021)

Background: Guidelines recommend the PRECISE-DAPT (PD) score to adapt duration of dual antiplatelet therapy due to bleeding risk. However, there is first evidence that PD predicts mortality and ischemic events as well. Methods: We investigated PD Sco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced59cd7a13d2a58a171fa36c5118c2f
https://doi.org/10.1016/j.ijcha.2021.100750