Výsledky vyhledávání - "Maike A. Laussmann"

The Caspase-8 Dimerization/Dissociation Balance Is a Highly Potent Regulator of Caspase-8, -3, -6 Signaling*

Autor: Markus Rehm, Maximilian L. Würstle, Maike A. Laussmann

Publikováno v: Journal of Biological Chemistry. 285:33209-33218

Apoptosis is driven by positive feedback activation between aspartate-specific cysteinyl proteases (caspases). These feedback loops ensure the swift and efficient elimination of cells upon initiation of apoptosis execution. At the same time, the sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2d802d310087dc7e1dfc3ab355df22
https://doi.org/10.1074/jbc.m110.113860

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RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts

Autor: Jordi Xiol, Stephen Cusack, Yohann Couté, Maike A. Laussmann, Elisa Cora, David Homolka, Simon J. Conn, Ravi Sachidanandam, Ramesh S. Pillai, Anne Ephrussi, Pietro Spinelli, Zhaolin Yang, Jan Kadlec, Marko Kaksonen

Publikováno v: Cell
Cell, 2014, 157 (7), pp.1698-1711. ⟨10.1016/j.cell.2014.05.018⟩
Cell, Elsevier, 2014, 157 (7), pp.1698-1711. ⟨10.1016/j.cell.2014.05.018⟩

Germline-specific Piwi-interacting RNAs (piRNAs) protect animal genomes against transposons and are essential for fertility. piRNAs targeting active transposons are amplified by the ping-pong cycle, which couples Piwi endonucleolytic slicing of targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f957a2268123ddbcf518ce975da65cf4
https://hal.science/hal-02135109

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Proteasome Inhibition Can Impair Caspase-8 Activation upon Submaximal Stimulation of Apoptotic Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Signaling*

Autor: Markus Rehm, Jochen H. M. Prehn, Lorna Flanagan, Maike A. Laussmann, Bartłomiej Tomiczek, Christian T. Hellwig, Heinrich J. Huber, Egle Passante

Publikováno v: Journal of Biological Chemistry; Vol 287
Journal of Biological Chemistry

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can induce extrinsic apoptosis, resulting in caspase-8 activation, but may also initiate transcription-dependent prosurvival signaling. Proteasome inhibitors were suggested to promote TR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d50673bbee5f5a45bc48b052dd35e29
https://europepmc.org/articles/PMC3340270/

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The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome

Autor: Maximilian L. Würstle, Maike A. Laussmann, Markus Rehm

Publikováno v: Experimental cell research. 318(11)

Key structural and catalytic features are conserved across the entire family of cysteine-dependent aspartate-specific proteases (caspases). Of the caspases involved in apoptosis signal transduction, the initiator caspases-2, -8 and -9 are activated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c54561afe9d73108e08cb6890f88ec
https://pubmed.ncbi.nlm.nih.gov/22406265

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Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

Autor: Jochen H. M. Prehn, Heiko Düssmann, Maike A. Laussmann, Maria Eugenia Delgado, Egle Passante, Judith A. Rauen, Maximilian L. Würstle, Markus Rehm, Marc Devocelle

Publikováno v: Cell Death and Differentiation; Vol 18

Antiapoptotic Bcl-2 family proteins are often highly expressed in chemotherapy-resistant cancers and impair mitochondrial outer membrane permeabilisation (MOMP), an important requirement for caspase activation via the intrinsic apoptosis pathway. Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9114e514fc6778aacb8d738678a22c22
https://europepmc.org/articles/PMC3130899/

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Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death

Autor: Maike A. Laussmann, Markus Rehm, Heinrich J. Huber, Jochen H. M. Prehn

Publikováno v: BMC Systems Biology, Vol 4, Iss 1, p 9 (2010)
BMC Systems Biology

Background Apoptosis is an essential cell death process throughout the entire life span of all metazoans and its deregulation in humans has been implicated in many proliferative and degenerative diseases. Mitochondrial outer membrane permeabilisation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09538b97a1f95b48660850816aac986
https://doi.org/10.1186/1752-0509-4-9

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Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways

Autor: Maike A. Laussmann, Markus Rehm, Lydia Dyck, Maria Eugenia Delgado

Publikováno v: Cell Death & Disease

Autophagic and proteasomal degradation constitute the major cellular proteolysis pathways. Their physiological and pathophysiological adaptation and perturbation modulates the relative abundance of apoptosis-transducing proteins and thereby can posit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161df267fe9efff202a48e3b8d81023b
https://doi.org/10.1038/cddis.2013.520

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