Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Maike, Sander"'
Autor:
Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-16 (2023)
Summary Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islet
Externí odkaz:
https://doaj.org/article/ff71f86b08274f6ea980a103f69cf1c4
Autor:
Matthew Wortham, Fenfen Liu, Austin R. Harrington, Johanna Y. Fleischman, Martina Wallace, Francesca Mulas, Medhavi Mallick, Nicholas K. Vinckier, Benjamin R. Cross, Joshua Chiou, Nisha A. Patel, Yinghui Sui, Carolyn McGrail, Yesl Jun, Gaowei Wang, Ulupi S. Jhala, Roland Schüle, Orian S. Shirihai, Mark O. Huising, Kyle J. Gaulton, Christian M. Metallo, Maike Sander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Adaptation of the islet β cell insulin-secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we have shown that nutrient-stimulated histone acetylati
Externí odkaz:
https://doaj.org/article/b59ff5cf14e54435855ccfd8a98f4b14
Autor:
Sandra Heller, Zhijian Li, Qiong Lin, Ryan Geusz, Markus Breunig, Meike Hohwieler, Xi Zhang, Gopika G. Nair, Thomas Seufferlein, Matthias Hebrok, Maike Sander, Cécile Julier, Alexander Kleger, Ivan G. Costa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is
Externí odkaz:
https://doaj.org/article/4622ff7d00c840df9df59d2628589a8c
Autor:
Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier, Konstantinos-Dionysios Alysandratos, David A. Roberts, Jinzhao Wang, Samy Kefalopoulou, Araceli Ramirez, Yunjiang Qiu, Joshua Chiou, Kyle J. Gaulton, Bing Ren, Darrell N. Kotton, Maike Sander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers a
Externí odkaz:
https://doaj.org/article/a8ff109def3c49e6a1431185b2073726
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract SOX9 (Sex-determining region Y Box 9) is a well-characterized transcription factor that is a marker for progenitor cells in various tissues. In the liver, cells delineated by SOX9 are responsible for regenerating liver parenchyma when cell p
Externí odkaz:
https://doaj.org/article/1db28909f5914c96b75d5b4abc666999
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Co-localized combinations of histone modifications (“chromatin states”) have been shown to correlate with promoter and enhancer activity. Changes in chromatin states over multiple time points (“chromatin state trajectories
Externí odkaz:
https://doaj.org/article/a294f498830d4bb1a6f3ff99a0c34a6a
Autor:
Nicholas K. Vinckier, Nisha A. Patel, Ryan J. Geusz, Allen Wang, Jinzhao Wang, Ileana Matta, Austin R. Harrington, Matthew Wortham, Nichole Wetton, Jianxun Wang, Ulupi S. Jhala, Michael G. Rosenfeld, Christopher W. Benner, Hung-Ping Shih, Maike Sander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers r
Externí odkaz:
https://doaj.org/article/219e2bb5225f43dcb77d228c096f4de8
Autor:
Michael Shum, Mayuko Segawa, Raffi Gharakhanian, Ana Viñuela, Matthew Wortham, Siyouneh Baghdasarian, Dane M. Wolf, Samuel B. Sereda, Laura Nocito, Linsey Stiles, Zhiqiang Zhou, Vincent Gutierrez, Maike Sander, Orian S. Shirihai, Marc Liesa
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101403- (2022)
Objective: The contribution of beta-cell dysfunction to type 2 diabetes (T2D) is not restricted to insulinopenia in the late stages of the disease. Elevated fasting insulinemia in normoglycemic humans is a major factor predicting the onset of insulin
Externí odkaz:
https://doaj.org/article/9dc2c70f85334be6a42fd766bfb0b160
Autor:
Wen Jin, Francesca Mulas, Bjoern Gaertner, Yinghui Sui, Jinzhao Wang, Ileana Matta, Chun Zeng, Nicholas Vinckier, Allen Wang, Kim-Vy Nguyen-Ngoc, Joshua Chiou, Klaus H. Kaestner, Kelly A. Frazer, Andrea C. Carrano, Hung-Ping Shih, Maike Sander
Publikováno v:
iScience, Vol 21, Iss , Pp 681-694 (2019)
Summary: Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes. MicroRNAs (miRNAs) are im
Externí odkaz:
https://doaj.org/article/a9bcb8fa84904ad59b0a30cfe0ed2af3
Autor:
Klaus H. Kaestner, Martha Campbell–Thompson, Yuval Dor, Ronald G. Gill, Benjamin Glaser, Seung K. Kim, Maike Sander, Cherie Stabler, Andrew F. Stewart, Alvin C. Powers
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101323- (2021)
Background: The pancreatic β cell, as the sole source of the vital hormone insulin, has been under intensive study for more than a century. Given the potential of newly created insulin-producing cells as a treatment or even cure of type 1 diabetes (
Externí odkaz:
https://doaj.org/article/176e01f999a345899f3c242dc7786c64