Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Maike, Getwan"'
Autor:
Markus Maerker, Maike Getwan, Megan E. Dowdle, Jason C. McSheene, Vanessa Gonzalez, José L. Pelliccia, Danielle S. Hamilton, Valeria Yartseva, Charles Vejnar, Melanie Tingler, Katsura Minegishi, Philipp Vick, Antonio J. Giraldez, Hiroshi Hamada, Rebecca D. Burdine, Michael D. Sheets, Martin Blum, Axel Schweickert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present e
Externí odkaz:
https://doaj.org/article/2eb07da85f2e46aaa1d04d13bd6e2bee
Autor:
Philipp Vick, Jennifer Kreis, Isabelle Schneider, Melanie Tingler, Maike Getwan, Thomas Thumberger, Tina Beyer, Axel Schweickert, Martin Blum
Publikováno v:
iScience, Vol 2, Iss , Pp 76-85 (2018)
Summary: Nodal signaling controls asymmetric organ placement during vertebrate embryogenesis. Nodal is induced by a leftward fluid flow at the ciliated left-right organizer (LRO). The mechanism of flow sensing, however, has remained elusive. pkd2 enc
Externí odkaz:
https://doaj.org/article/3cfbf417e05f495e88e932b7da07f3f6
Autor:
Kai M. Schmidt-Ott, Amar J. Majmundar, Friedhelm Hildebrandt, Thomas M. Kitzler, Florian Buerger, Nina Mann, Maike Getwan, Sherif El Desoky, Michael M. Kaminski, Konstantin Deutsch, Tian Shen, Ana C. Onuchic-Whitford, Verena Klämbt, Jameela A. Kari, Youying Mao, Shirlee Shril, Soeren S. Lienkamp, Mohamed A. Shalaby, Max Werth, Jonathan Barasch
Publikováno v:
Nephrol Dial Transplant
Background An underlying monogenic cause of early-onset chronic kidney disease (CKD) can be detected in ∼20% of individuals. For many etiologies of CKD manifesting before 25 years of age, >200 monogenic causative genes have been identified to date,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed77a32e4120e403cdf608066d634934
https://doi.org/10.1093/ndt/gfaa215
https://doi.org/10.1093/ndt/gfaa215
Autor:
Sophie Schroda, Anselm Hoppmann, Anna Köttgen, Pascal Schlosser, Florian Heeg, Maike Getwan, Weiting Song, Kelli Grand, Konstantin Deutsch, Soeren S. Lienkamp, Rebecca Diehl, Ekkehart Lausch, Friedhelm Hildebrandt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Cilia are tubulin-based cellular appendages, and their dysfunction has been linked to a variety of genetic diseases. Ciliary chondrodysplasia is one such condition that can co-occur with cystic kidney disease and other organ manifestatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e56a961f45f047d8fad5c47de189b8
https://doi.org/10.5167/uzh-207742
https://doi.org/10.5167/uzh-207742
Autor:
Maike Getwan, Hiroshi Hamada, Jose L Pelliccia, Antonio J. Giraldez, Jason C. McSheene, Axel Schweickert, Michael D. Sheets, Melanie Tingler, Megan E. Dowdle, Philipp Vick, Charles E. Vejnar, Rebecca D. Burdine, Markus Maerker, Katsura Minegishi, Valeria Yartseva, Danielle S Hamilton, Martin Blum, Vanessa Gonzalez
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel Pkd2 is crucial for flow sensing. How this flow signal is furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5cb13bc3d01a5ff523c444f47823fe
https://doi.org/10.5167/uzh-208861
https://doi.org/10.5167/uzh-208861
POS-430 CRISPR/CAS9 TARGETING TTTC30A MIMICS CILIARY CHONDRODYSPLASIA WITH POLYCYSTIC KIDNEY DISEASE
Autor:
Maike Getwan, Konstantin Deutsch, Ekkehart Lausch, Pascal Schlosser, R. Diehl, F. Heeg, Anna Köttgen, Friedhelm Hildebrandt, W. Song, Sophie Schroda, Lienkamp Ss, Anselm Hoppmann, K. Grand
Publikováno v:
Kidney International Reports, Vol 6, Iss 4, Pp S187-(2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995ce281c3a939787c380a1e56aa1532
http://www.sciencedirect.com/science/article/pii/S2468024921005994
http://www.sciencedirect.com/science/article/pii/S2468024921005994
Autor:
Friedhelm Hildebrandt, Anselm Hoppmann, W. Song, Ekkehart Lausch, A. Koettgen, Konstantin Deutsch, Soeren S. Lienkamp, R. Diehl, F. Heeg, Maike Getwan, Pascal Schlosser, Sophie Schroda, K. Grand
Skeletal ciliopathies (e.g. Jeune syndrome, short rib polydactyly syndrome, Sensenbrenner syndrome) are frequently associated with cystic kidney disease and other organ manifestations, but a common molecular mechanism has remained elusive.We establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d4edc349b9af2ae9c2b97153d8904d
https://doi.org/10.1101/2020.11.27.400994
https://doi.org/10.1101/2020.11.27.400994
Autor:
Anne Christians, Soeren S. Lienkamp, Maike Getwan, Ruthild G. Weber, Robert Geffers, Imke Hennies, Zoran Gucev, Arne Christians, Frank Brand, Andreas Kispert, Anna-Carina Weiss, Ann Christin Gjerstad, Helge Martens, Dieter Haffner, Velibor Tasic, Tomáš Seeman, Anna Bjerre
Publikováno v:
European journal of human genetics : EJHG
England
European Journal of Human Genetics
England
European Journal of Human Genetics
Although over 50 genes are known to cause renal malformation if mutated, the underlying genetic basis, most easily identified in syndromic cases, remains unsolved in most patients. In search of novel causative genes, whole-exome sequencing in a patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf554eb4342b38ec7820ace43d47ed80
https://hdl.handle.net/10033/622498
https://hdl.handle.net/10033/622498
Autor:
Maike Getwan, Soeren S. Lienkamp
Publikováno v:
Cell and Tissue Research. 369:143-157
Xenopus is a versatile model organism increasingly used to study organogenesis and genetic diseases. The rapid embryonic development, targeted injections, loss- and gain-of-function experiments and an increasing supply of tools for functional in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abdbfdce04f627e3f39c3c1129defd2
https://doi.org/10.1007/s00441-017-2611-2
https://doi.org/10.1007/s00441-017-2611-2
Autor:
Soeren S. Lienkamp, Richard P. Lifton, Benjamin Dekel, Anna Carina Weiss, Friedhelm Hildebrandt, Vincent Cavaillès, Michael M. Kaminski, Amelie T. van der Ven, Tobias Bohnenpoll, Johanna Magdalena Schmidt, Rachel Shukrun, Hadas Ityel, Ali G. Gharavi, Eugen Widmeier, Weining Lu, Hagith Yonath, Jing Chen, Yair Anikster, Andreas Kispert, Nina Mann, Stuart B. Bauer, Daniella Magen, Asaf Vivante, Robert Kleta, Velibor Tasic, Shirlee Shril, Maike Getwan, Catherine Teyssier, Horia Stanescu, Simone Sanna-Cherchi
Publikováno v:
Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (8), pp.2364-2376. ⟨10.1681/ASN.2016060694⟩
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (8), pp.2364-2376. ⟨10.1681/ASN.2016060694⟩
Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of CKD in the first three decades of life. However, for most patients with CAKUT, the causative mutation remains unknown. We identified a kindred with an autosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d40e960105ae5741287ba5bdd27a73b
https://doi.org/10.1681/asn.2016060694
https://doi.org/10.1681/asn.2016060694