Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Maike, Buchner"'
Autor:
Lisa Pfeuffer, Viola Siegert, Julia Frede, Leonie Rieger, Riccardo Trozzo, Niklas de Andrade Krätzig, Sandra Ring, Shamim Sarhadi, Nicole Beck, Stefan Niedermeier, Mar Abril-Gil, Mohamed Elbahloul, Marianne Remke, Katja Steiger, Ruth Eichner, Julia Jellusova, Roland Rad, Florian Bassermann, Christof Winter, Jürgen Ruland, Maike Buchner
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), remain incurable, with MM particularly prone to relapse. Our study introduces a novel mouse model with active RANK signaling and the TCL1 oncogene, di
Externí odkaz:
https://doaj.org/article/5d14702a54c246dbbd1aa8836923caa2
Autor:
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Current therapeutic approaches in chronic lymphocytic leukemia (CLL) focus on the suppression of PI3K/AKT signaling. Here, the authors show that CLL cells are vulnerable to hyperactivation of the PI3K/AKT signaling pathway and suggest this as a promi
Externí odkaz:
https://doaj.org/article/48da348450fd4d8c8348861c88888a7b
Autor:
Hye Kyung Lee, Manuela A. Hoechstetter, Maike Buchner, Trang Thu Pham, Jin Won Huh, Katharina Müller, Sabine Zange, Heiner von Buttlar, Philipp Girl, Roman Wölfel, Lisa Brandmeier, Lisa Pfeuffer, Priscilla A. Furth, Clemens-Martin Wendtner, Lothar Hennighausen
Publikováno v:
Blood Advances. 7:2214-2227
Patients with chronic lymphocytic leukemia (CLL) treated with B-cell pathway inhibitors and anti-CD20 antibodies exhibit low humoral response rates following SARS-CoV-2 vaccination. To investigate this observation, a prospective single-institution st
Autor:
Veronika Ecker, Lisa Brandmeier, Martina Stumpf, Piero Giansanti, Aida Varela Moreira, Lisa Pfeuffer, Marcel Fens, Junyan Lu, Bernhard Küster, Thomas Engleitner, Simon Heidegger, Ingo Ringshausen, Thorsten Zenz, Clemens Wendtner, Markus Müschen, Jürgen Ruland, Maike Buchner
Despite several potent targeted treatments for chronic lymphocytic leukemia (CLL), the clinical challenge of treating drug-resistant disease is emerging. In this study, we discovered that the dual-specific phosphatases DUSP1 and DUSP6 are required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b32e9a6e97279a251062a7c002825e6
https://doi.org/10.21203/rs.3.rs-2481423/v1
https://doi.org/10.21203/rs.3.rs-2481423/v1
Autor:
Jana Zecha, Florian P. Bayer, Svenja Wiechmann, Julia Woortman, Nicola Berner, Julian Müller, Annika Schneider, Karl Kramer, Mar Abril-Gil, Thomas Hopf, Leonie Reichart, Lin Chen, Fynn M. Hansen, Severin Lechner, Patroklos Samaras, Stephan Eckert, Ludwig Lautenbacher, Maria Reinecke, Firas Hamood, Polina Prokofeva, Larsen Vornholz, Chiara Falcomatà, Madeleine Dorsch, Ayla Schröder, Anton Venhuizen, Stephanie Wilhelm, Guillaume Médard, Gabriele Stoehr, Jürgen Ruland, Barbara M. Grüner, Dieter Saur, Maike Buchner, Benjamin Ruprecht, Hannes Hahne, Matthew The, Mathias Wilhelm, Bernhard Kuster
Although most cancer drugs modulate the activities of cellular pathways by changing posttranslational modifications (PTMs), little is known regarding the extent and the time- and dose-response characteristics of drug-regulated PTMs. In this work, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c87d1d00a70e16be3fa10729e9a3ae2
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85152012772
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85152012772
Autor:
Hye Kyung Lee, Manuela A. Hoechstetter, Maike Buchner, Trang Thu Pham, Jin Won Huh, Katharina Müller, Sabine Zange, Heiner von Buttlar, Philipp Girl, Roman Wölfel, Lisa Brandmeier, Lisa Pfeuffer, Priscilla A. Furth, Clemens-Martin Wendtner, Lothar Hennighausen
Publikováno v:
medRxiv
Patients with chronic lymphocytic leukemia (CLL) treated with B-cell pathway inhibitors and anti-CD20 antibodies exhibit low humoral response rate (RR) following SARS-CoV-2 vaccination. To investigate the relationship between the initial transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120666c1d986af05b570304a4902434e
https://doi.org/10.1101/2022.09.21.22280205
https://doi.org/10.1101/2022.09.21.22280205
Autor:
Lisa Pfeuffer, Lisa Brandmeier, Nicole Beck, Katja Steiger, Clemens-Martin Wendtner, Jürgen Ruland, Maike Buchner
Publikováno v:
Blood. 140:606-607
Autor:
Marco Benkisser-Petersen, Maike Buchner, Arlette Dörffel, Marcus Dühren-von-Minden, Rainer Claus, Kathrin Kläsener, Kerstin Leberecht, Meike Burger, Christine Dierks, Hassan Jumaa, Fabio Malavasi, Michael Reth, Hendrik Veelken, Justus Duyster, Katja Zirlik
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0169159 (2016)
The survival and proliferation of CLL cells depends on microenvironmental contacts in lymphoid organs. CD38 is a cell surface receptor that plays an important role in survival and proliferation signaling in CLL. In this study we demonstrate SYK's dir
Externí odkaz:
https://doaj.org/article/62e623d9e389493dba53993b6041906a
Autor:
Zhengshan Chen, Maike Buchner, Kadriye Nehir Cosgun, Pauline Soulas-Sprauel, Nora Heisterkamp, Veronika Ecker, Lars Klemm, Anne Marie Knapp, Joo Y. Song, Friedemann Kiefer, Supraja Saravanakumar, Markus Müschen, Thierry Martin, Mark Robinson, Hassan Jumaa, Vu N. Ngo, Dana Ghergus, Tanya Siddiqi, Kohei Kume, Laura Oksa, Mickaël Martin, Teresa Sadras, Jevon Cutler, Lili Wang, Janet Winchester, Eric Meffre, Gal Lenz, Wing C. Chan, Jürgen Ruland, Akhilesh Pandey
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (10), ⟨10.1016/j.molcel.2021.03.043⟩
Mol Cell
Molecular Cell, Elsevier, 2021, 81 (10), ⟨10.1016/j.molcel.2021.03.043⟩
Mol Cell
Even though SYK and ZAP70 kinases share high sequence homology and serve analogous functions, their expression in B and T cells is strictly segregated throughout evolution. Here, we identified aberrant ZAP70 expression as a common feature in a broad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f86a9abf29a5fa0e6e1f2a1d1a94d8c
https://hal.archives-ouvertes.fr/hal-03465916
https://hal.archives-ouvertes.fr/hal-03465916
Autor:
Nathalie Vahl, Begüm Alankus, Torben Gehring, Tanja Neumayer, Martina Braun, Maike Buchner, Thorsten Zenz, Wilko Weichert, Stephan Macher-Göppinger, Veronika Ecker, Jürgen Ruland
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine
Enforced RANK signaling in B cells drives systemic autoimmunity and CLL development. The survival of CLL cells depends on microenvironmental RANKL, and inhibition of RANKL–RANK signaling kills murine and human CLL cells.
Clinical evidence sugg
Clinical evidence sugg