Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Maik Stein"'
Autor:
Viktor Glaser, Christian Flugel, Jonas Kath, Weijie Du, Vanessa Drosdek, Clemens Franke, Maik Stein, Axel Pruß, Michael Schmueck-Henneresse, Hans-Dieter Volk, Petra Reinke, Dimitrios L. Wagner
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Multiple genetic modifications may be required to develop potent off-the-shelf chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling
Externí odkaz:
https://doaj.org/article/f8d60eb28eca4425aa804f59ead59de2
Autor:
Jonas Kath, Weijie Du, Alina Pruene, Tobias Braun, Bernice Thommandru, Rolf Turk, Morgan L. Sturgeon, Gavin L. Kurgan, Leila Amini, Maik Stein, Tatiana Zittel, Stefania Martini, Lennard Ostendorf, Andreas Wilhelm, Levent Akyüz, Armin Rehm, Uta E. Höpken, Axel Pruß, Annette Künkele, Ashley M. Jacobi, Hans-Dieter Volk, Michael Schmueck-Henneresse, Renata Stripecke, Petra Reinke, Dimitrios L. Wagner
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 311-330 (2022)
Chimeric antigen receptor (CAR) redirected T cells are potent therapeutic options against hematological malignancies. The current dominant manufacturing approach for CAR T cells depends on retroviral transduction. With the advent of gene editing, ins
Externí odkaz:
https://doaj.org/article/007e0c658baf459b90751503a142b022
Autor:
Elena Crespo, Anna Vidal-Alabró, Thomas Jouve, Pere Fontova, Maik Stein, Sonila Mocka, Maria Meneghini, Anett Sefrin, Petra Hruba, Montserrat Gomà, Alba Torija, Laura Donadeu, Alex Favà, Josep M. Cruzado, Edoardo Melilli, Francesc Moreso, Ondrej Viklicky, Frederike Bemelman, Petra Reinke, Josep Grinyó, Nuria Lloberas, Oriol Bestard
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Achieving fast immunosuppression blood exposure after kidney transplantation is key to abrogating both preformed and de novo anti-donor humoral and cellular alloresponses. However, while tacrolimus (TAC) is the cornerstone immunosuppressant inhibitin
Externí odkaz:
https://doaj.org/article/e1f40afe8ab94a93a922e44c70f720c5
Autor:
Daniel Kaiser, Natalie Maureen Otto, Oliver McCallion, Henrike Hoffmann, Ghazaleh Zarrinrad, Maik Stein, Carola Beier, Isabell Matz, Marleen Herschel, Joanna Hester, Guido Moll, Fadi Issa, Petra Reinke, Andy Roemhild
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cell therapies have significant therapeutic potential in diverse fields including regenerative medicine, transplantation tolerance, and autoimmunity. Within these fields, regulatory T cells (Treg) have been deployed to ameliorate aberrant immune resp
Externí odkaz:
https://doaj.org/article/50e3a4d1a00a4962920bd8d701178c0c
Autor:
Arturo Blazquez-Navarro, Thomas Schachtner, Ulrik Stervbo, Anett Sefrin, Maik Stein, Timm H Westhoff, Petra Reinke, Edda Klipp, Nina Babel, Avidan U Neumann, Michal Or-Guil
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 5, p e1005998 (2018)
BK virus (BKV) associated nephropathy affects 1-10% of kidney transplant recipients, leading to graft failure in about 50% of cases. Immune responses against different BKV antigens have been shown to have a prognostic value for disease development. D
Externí odkaz:
https://doaj.org/article/1e52937cb0a24a24b19d2916a3b414a5
Autor:
Jonas Kath, Weijie Du, Stefania Martini, Magdi Elsallab, Clemens Franke, Laura Marie Hartmann, Vanessa Drosdek, Viktor Glaser, Maik Stein, Michael Schmueck-Henneresse, Petra Reinke, Hans-Dieter Volk, Mohamed Abou-el-Enein, Dimitrios Laurin Wagner
Publikováno v:
Blood Advances.
Graft-versus-host disease (GvHD) is a major risk upon administration of allogeneic Chimeric Antigen Receptor (CAR) redirected T cells to HLA-unmatched patients. Gene editing can be used to disrupt potentially alloreactive T cell receptors (TCRs) in C
Autor:
Gilles Blancho, Maria Meneghini, Magali Giral, Edoardo Melilli, Juan Irure, Martina Koch, Miriam C. Banas, Elena Crespo, Raphaël Duivenvoorden, Cécile Braudeau, Anett Sefrin, Kathryn J. Wood, Friedrich Thaiss, Oriol Bestard, Bernhard Banas, Petra Hruba, Petra Reinke, Frederike J. Bemelman, Björn Nashan, Sophie Brouard, Nils Lachmann, Natalie M Otto, Alberto Sanchez-Fueyo, Maik Stein, Liu Hu, Lucia Stranavova, Ondrej Viklicky, H.-D. Volk, Josep M. Grinyó, Gantuja Bold, Sophia Christakoudi, Juan Carlos Ruiz
Publikováno v:
American Journal of Transplantation, 21, 8, pp. 2833-2845
American journal of transplantation, 21(8), 2833-2845. Wiley-Blackwell
American Journal of Transplantation, 21, 2833-2845
American journal of transplantation, 21(8), 2833-2845. Wiley-Blackwell
American Journal of Transplantation, 21, 2833-2845
Item does not contain fulltext Personalizing immunosuppression is a major objective in transplantation. Transplant recipients are heterogeneous regarding their immunological memory and primary alloimmune susceptibility. This biomarker-guided trial in
Autor:
Axel Pruß, Petra Reinke, Hans-Dieter Volk, Bernice Thommandru, Uta E. Höpken, Dimitrios L. Wagner, Annette Künkele, Rolf Turk, Levent Akyüz, Michael Schmueck-Henneresse, Armin Rehm, Stefania Martini, Leila Amini, Andreas Wilhelm, Weijie Du, Tatiana Zittel, Lennard Ostendorf, Ashley M. Jacobi, Jonas Kath, Maik Stein
Chimeric Antigen Receptor (CAR) redirected T cells are a potent treatment option for certain hematological malignancies. Recently, site-specific insertion of CARs into the T cell receptor (TCR) alpha constant (TRAC) locus using gene editing and adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d539c6638dc00a0eeefc2c0d90868
http://edoc.mdc-berlin.de/20007/7/20007suppl.zip
http://edoc.mdc-berlin.de/20007/7/20007suppl.zip
Preformed donor-reactive T cells are relatively resistant to standard immunosuppression and account for an increased incidence of T cell-mediated rejection (TCMR) and inferior kidney allograft outcomes. We analyzed 150 living donor kidney transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075e529a18eac73074fc2759357184be
https://www.zora.uzh.ch/id/eprint/199657/
https://www.zora.uzh.ch/id/eprint/199657/
Publikováno v:
Transplantation. 101:e315-e325
Detectable cytomegalovirus (CMV)-specific T cells in CMV-seronegative kidney transplant recipients (KTRs) have been attributed to an absence of circulating antibodies despite CMV sensitization. The diagnostic value of CMV-specific T cells, however, n