Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Maik Schuler"'
Publikováno v:
Environmental and molecular mutagenesisREFERENCES. 63(5)
Genotoxicity testing guidelines require the assessment of the clastogenic and aneugenic potential of compounds. While in vitro micronucleus assays detect both types of endpoints, it requires labor-intensive microscopic scoring and does not discrimina
Publikováno v:
The Journal of toxicological sciences. 47(1)
The nonclinical safety package to support development and approval of drugs intended to be administered by topical application generally follows International Council for Harmonisation multidisciplinary 3 (ICH M3) and topic specific safety (ICH S) gu
Autor:
Zaher A. Radi, Gary Seitis, Yutian Zhan, Maria Engel, Stephanie L. Coffing, Katherine Hales, Maik Schuler, Lindsay Tomlinson, Saurabh G. Vispute, Jon C. Cook, Brett D. Hollingshead, Jennifer R. Cheung, Michael Homiski, Elizabeth Rubitski, Andrew Robertson
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 180(1)
Risk management of in vitro aneugens for topically applied compounds is not clearly defined because there is no validated methodology to accurately measure compound concentration in proliferating stratum basale keratinocytes of the skin. Here, we exp
Autor:
Jim Finley, Lindsay Tomlinson, Sarah P. Nicholson, Stacey R. Oppenheimer, Jessica L. Moore, Maik Schuler, Nathan Heath Patterson, Kevin Beaumont, Brett D. Hollingshead, Zaher A. Radi, Colleen M. Doshna, Casey Ritenour, Richard M. Caprioli, Shawn P. O'Neil, Jon C. Cook, Jason Barricklow, Amanda King-Ahmad, Saurabh G. Vispute, Jeremy L. Norris
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 123
Systemic toxicity assessments for oral or parenteral drugs often utilize the concentration of drug in plasma to enable safety margin calculations for human risk assessment. For topical drugs, there is no standard method for measuring drug concentrati
Autor:
Steven M. Bryce, Laura Custer, Kerry L. Dearfield, Carole L. Yauk, Giel Hendriks, Ashley Allemang, Sheila M. Galloway, Maik Schuler, Stefan Pfuhler, Patricia A Escobar, Azeddine Elhajouji, Gladys Ouedraogo, Albert J. Fornace, Heng-Hong Li, Jennifer C. Sasaki, Daniel J Roberts, Yasmin Dietz, Ulrike Hemmann, Jan van Benthem, Véronique Thybaud, Roland Froetschl, Lauren Peel, Mirjam Luijten
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94120698a05b8acf2acfae209b20a2b1
http://hdl.handle.net/10029/623463
http://hdl.handle.net/10029/623463
Autor:
Véronique Thybaud, Jos C. S. Kleinjans, Jason H. Bielas, Paul D. White, Francesco Marchetti, Ann T. Doherty, Carole L. Yauk, Yukari Totsuka, Masamitsu Honma, Stephen D. Dertinger, Maik Schuler
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 847:403022. Elsevier
We live in an era of 'big data', where the volume, velocity, and variety of the data being generated is increasingly influencing the way toxicological sciences are practiced. With this in mind, a workgroup was formed for the 2017 International Worksh
Autor:
Richard A. Spellman, David Kirkland, Véronique Thybaud, Melanie Guérard, Stephen D. Dertinger, Steven M. Bryce, Andreas Zeller, Jeffrey C. Bemis, Maik Schuler, Sabrina Wilde, Elisabeth Lorge, Andreas Sutter, Ulrike Hemmann, Nina Queisser, Pekka T. Heikkinen, Derek T. Bernacki, Maria Engel
Publikováno v:
Environmental and Molecular Mutagenesis. 58:146-161
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p
Autor:
Kenichi Masumura, Roland Froetschl, Azeddine Elhajouji, Francesco Marchetti, Micheline Kirsch-Volders, David A. Eastmond, David Tweats, Francesca Pacchierotti, Maik Schuler, Anthony M. Lynch
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a review of the scientific literature on the biological mechanisms of aneuploidy in mammalian cells and methods used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1beb47e5cb23d9b121a5188fc38813
https://doi.org/10.1016/j.mrgentox.2019.02.006
https://doi.org/10.1016/j.mrgentox.2019.02.006
Autor:
Maik Schuler, Roland Froetschl, Francesca Pacchierotti, Anthony M. Lynch, David Tweats, Kenichi Masumura, Francesco Marchetti, Micheline Kirsch-Volders, David A. Eastmond, Azeddine Elhajouji
As part of the 7th International Workshops on Genotoxicity Testing held in Tokyo, Japan in November 2017, a workgroup of experts reviewed and assessed the risk of aneugens for human health. The present manuscript is one of three manuscripts from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11647076242f23bbd6e3f7aa3790db73
http://hdl.handle.net/20.500.12079/51187
http://hdl.handle.net/20.500.12079/51187
Autor:
Ben Gilby, Maik Schuler, Jennifer Y. Tanir, Shambhu K Roy, Kiyohiro Hashimoto, James Whitwell, Azeddine Elhajouji, Christopher S Farabaugh, David P. Lovell, Yan Li, Mick Fellow
A database of the micronuclei counts was built up for historical negative control data from human lymphocyte in vitro micronuclei tests (MnVit) carried out in 8 laboratories with experience of the method. The mean incidence of micronucleated cells (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3065302df8498969d5b3700a7b28928e
https://openaccess.sgul.ac.uk/id/eprint/110519/1/1-s2.0-S1383571818301578-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/110519/1/1-s2.0-S1383571818301578-main.pdf