Výsledky vyhledávání - "Maija-Katri Lehto"

Defective Central Tolerance in Aire-Deficient Mice is not Sufficient to Induce Symptomatic Autoimmunity During Lymphopenia-Induced T cell Proliferation

Autor: Maija-Katri Lehto, Seppo Meri, Hanna Jarva, Eero Smeds, Aaro Miettinen, T. Petteri Arstila, Eliisa Kekäläinen

Publikováno v: Scandinavian Journal of Immunology. 74:71-79

Transcriptional regulator autoimmune regulator (AIRE) controls thymic negative selection but it is also expressed in secondary lymphoid organs. The relative contribution of AIRE's central and peripheral function to the maintenance of tolerance is unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cba5aa41bb9eab7bdbdd061eec5f126
https://doi.org/10.1111/j.1365-3083.2011.02543.x

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Lymphopenia-induced proliferation in the absence of functional Autoimmune regulator (Aire) induces colitis in mice

Autor: Eero Smeds, Eliisa Kekäläinen, Ismo Ulmanen, T. Petteri Arstila, Nora Pöntynen, Pirkka T. Pekkarinen, Aaro Miettinen, Maija-Katri Lehto

Publikováno v: Immunology letters. 167(1)

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in Autoimmune regulator (Aire), a transcriptional regulator of negative selection in thymus. However, Aire is also expressed in periphery, but the full ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a492cd658fad947137d1042bf79ddf
https://pubmed.ncbi.nlm.nih.gov/26112418

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