Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Maija Puhka"'
Autor:
Misba Khan, Md. Khirul Islam, Mafiur Rahman, Bert Dhondt, Ileana Quintero, Maija Puhka, Panu M. Jaakkola, Urpo Lamminmäki, Janne Leivo
Publikováno v:
Nano Select, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Half of patients with renal cell carcinoma (RCC) develop metastases. New and noninvasive biomarkers are needed for the diagnosis of RCC. The study aims to develop an EV‐based assay for the detection of RCC using a highly sensitive nanopart
Externí odkaz:
https://doaj.org/article/e55164b7822c462caf1219c44a7c0720
Autor:
Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K. Giri, Rashmi B. Prasad, Rishi Das Roy, Lena M. Thorn, Antti Rannikko, Harry Holthöfer, Kim M. Gooding, Steven Sourbron, Denis Delic, Maria F. Gomez, Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106686- (2023)
Summary: Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover m
Externí odkaz:
https://doaj.org/article/5b53c14dd8ee490b811a4f2dffd31175
Autor:
Beate Vestad, Tuula A. Nyman, Malene Hove-Skovsgaard, Maria Stensland, Hedda Hoel, Anne-Marie Siebke Trøseid, Trude Aspelin, Hans Christian D. Aass, Maija Puhka, Johannes R. Hov, Susanne Dam Nielsen, Reidun Øvstebø, Marius Trøseid
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HIV and type 2 diabetes (T2D) are both associated with gut microbiota alterations, low-grade endotoxemia and increased cardiovascular risk. We investigated the potential role of plasma extracellular vesicles (EVs) in relation to these proces
Externí odkaz:
https://doaj.org/article/5dc77ae92990408783ee31665f79ebc9
Autor:
Mayank Saraswat, Beata Przybyla, Sakari Joenvaara, Tiialotta Tohmola, Tomas Strandin, Maija Puhka, Annukka Jouppila, Riitta Lassila, Risto Renkonen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cells shape their extracellular milieu by secreting intracellular products into the environment including extracellular vesicles which are lipid-bilayer limited membrane particles. These vesicles carry out a range of functions, including regulation o
Externí odkaz:
https://doaj.org/article/edf86c720a784046a358baa1ebd5a6e1
Autor:
Karina Barreiro, Om Prakash Dwivedi, Sami Valkonen, Per‐Henrik Groop, Tiinamaija Tuomi, Harry Holthofer, Antti Rannikko, Marjo Yliperttula, Pia Siljander, Saara Laitinen, Elina Serkkola, Taija af Hällström, Carol Forsblom, Leif Groop, Maija Puhka
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 12, Pp n/a-n/a (2021)
Abstract Urinary extracellular vesicles (uEV) are a topical source of non‐invasive biomarkers for health and diseases of the urogenital system. However, several challenges have become evident in the standardization of uEV pipelines from collection
Externí odkaz:
https://doaj.org/article/53420f988cd84400b27fc301f6eca21a
Autor:
Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton, James W. Dear, Juan M. Falcón‐Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge Mertens, Luca Musante, Eline Oeyen, Maija Puhka, Martin E. vanRoyen, Catherine Sánchez, Carolina Soekmadji, Visith Thongboonkerd, Volkert vanSteijn, Gerald Verhaegh, Jason P. Webber, Kenneth Witwer, Peter S.T. Yuen, Lei Zheng, Alicia Llorente, Elena S. Martens‐Uzunova
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to
Externí odkaz:
https://doaj.org/article/11056fe3164342fca660fd4db4496dcd
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract Antibody‐drug conjugates (ADCs) are a new class of anti‐cancer drugs that consist of a monoclonal antibody, a highly potent small‐molecule cytotoxic drug, and a chemical linker between the two. ADCs can selectively deliver cytotoxic dr
Externí odkaz:
https://doaj.org/article/43ebbc58b8f64e9583eeebbde772334f
Autor:
Mari Palviainen, Mayank Saraswat, Zoltán Varga, Diána Kitka, Maarit Neuvonen, Maija Puhka, Sakari Joenväärä, Risto Renkonen, Rienk Nieuwland, Maarit Takatalo, Pia R M Siljander
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236439 (2020)
Extracellular vesicles (EVs) in human blood are a potential source of biomarkers. To which extent anticoagulation affects their concentration, cellular origin and protein composition is largely unexplored. To study this, blood from 23 healthy subject
Externí odkaz:
https://doaj.org/article/6ddc547e08da4a20800508ae3f05d79c
Autor:
Mari Palviainen, Heikki Saari, Olli Kärkkäinen, Jenna Pekkinen, Seppo Auriola, Marjo Yliperttula, Maija Puhka, Kati Hanhineva, Pia R.-M. Siljander
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
One of the greatest bottlenecks in extracellular vesicle (EV) research is the production of sufficient material in a consistent and effective way using in vitro cell models. Although the production of EVs in bioreactors maximizes EV yield in comparis
Externí odkaz:
https://doaj.org/article/81836cafac754aa884a49354b75b06f6
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized that exosome-bound T-D
Externí odkaz:
https://doaj.org/article/5e7c9937327e48098ffdd421d894b730